Continuous Wave-Diffuse Optical Tomography (CW-DOT) in Human Brain Mapping: A Review

Sensors, Journal Year: 2025, Volume and Issue: 25(7), P. 2040 - 2040

Published: March 25, 2025

Continuous wave-diffuse optical tomography (CW-DOT) has emerged as a promising non-invasive neuroimaging technique for assessing brain function. Its ability to provide mapping with high spatial resolution over traditional functional near-infrared spectroscopy (fNIRS) garnered significant interest in clinical and cognitive neuroscience. In this review, we critically summarized the hardware, reconstruction algorithms, applications of CW-DOT human mapping, providing an up-to-date overview guidelines future studies conduct studies. ScienceDirect, PubMed, Web Science, IEEE Xplore databases were searched from their inception up 1 July 2024. A total 83 articles included final systematic review. The review focused on existing hardware systems, algorithms CW-DOT, both settings Finally, highlighted current challenges potential directions research, including absence standardized protocols pressing need enhanced quantitative precision. This underscores sophisticated capabilities particularly realm imaging. Extensive neuroscience research attested technique's anatomical precision reliability, establishing it potent instrument practice.

Language: Английский

Diffuse optical tomography for mapping cerebral hemodynamics and functional connectivity in delirium

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(6), P. 4032 - 4042

Published: May 3, 2024

Abstract INTRODUCTION Delirium is associated with mortality and new onset dementia, yet the underlying pathophysiology remains poorly understood. Development of imaging biomarkers has been difficult given challenging nature delirious patients. Diffuse optical tomography (DOT) offers a promising approach for investigating delirium its portability three‐dimensional capabilities. METHODS Twenty‐five matched non‐delirious patients ( n = 50) were examined using DOT, comparing cerebral oxygenation functional connectivity in prefrontal cortex during after an episode delirium. RESULTS Total hemoglobin values significantly decreased group, even resolution. Functional between dorsolateral dorsomedial was strengthened post‐resolution compared to episode; however, this relationship still weaker controls. DISCUSSION These findings highlight DOT's potential as biomarker measure impaired dysconnectivity Future studies should focus on role pathogenesis exploring etiological link dementias. Highlights We developed portable diffuse system bedside neuroimaging study hospital. implemented novel DOT task‐focused seed‐based correlation analysis. revealed strength resolution

Language: Английский

Investigating Sepsis-Associated Delirium Through Optical Neuroimaging: A New Frontier in Critical Care Research

Chemosensors, Journal Year: 2024, Volume and Issue: 12(12), P. 264 - 264

Published: Dec. 15, 2024

Sepsis is a life-threatening syndrome consisting of physiological, pathological, and biochemical abnormalities induced by infection which continues to be major public health burden. It remains one the most common reasons for intensive care unit (ICU) admission. Delirium precipitated sepsis in setting its neuropsychiatric complications that leads prolonged hospitalization, increased mortality, an risk incident dementia. Understanding pathophysiology neurobiological mechanisms sepsis-associated delirium difficult; neuroimaging biomarkers are lacking due difficulties with imaging critically ill patients. Optical techniques, including near-infrared spectroscopy diffuse optical tomography potentially promising approaches investigating this their portability high spatiotemporal resolution. In review, we examine emergence techniques study ICU how they can further advance our knowledge lead development improved preventative, predictive, therapeutic strategies.

Language: Английский