Experimental laboratory models as tools for understanding modifiable dementia risk DOI Creative Commons
Duncan Sinclair, Alison J. Canty, Jenna M. Ziebell

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(6), P. 4260 - 4289

Published: April 30, 2024

Experimental laboratory research has an important role to play in dementia prevention. Mechanisms underlying modifiable risk factors for are promising targets prevention but difficult investigate human populations due technological constraints and confounds. Therefore, controlled experiments models such as transgenic rodents, invertebrates vitro cultured cells increasingly used test strategies which target them prevent dementia. This review provides overview of experimental into 15 established putative factors: less early-life education, hearing loss, depression, social isolation, life stress, hypertension, obesity, diabetes, physical inactivity, heavy alcohol use, smoking, air pollution, anesthetic exposure, traumatic brain injury, disordered sleep. It explores how have been, can be, address questions about that cannot readily be addressed studies. HIGHLIGHTS: Modifiable Interrogation mechanisms is populations. Studies using diverse revealing mechanisms. We factors. Laboratory science contribute uniquely

Language: Английский

Experimental laboratory models as tools for understanding modifiable dementia risk DOI Creative Commons
Duncan Sinclair, Alison J. Canty, Jenna M. Ziebell

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(6), P. 4260 - 4289

Published: April 30, 2024

Experimental laboratory research has an important role to play in dementia prevention. Mechanisms underlying modifiable risk factors for are promising targets prevention but difficult investigate human populations due technological constraints and confounds. Therefore, controlled experiments models such as transgenic rodents, invertebrates vitro cultured cells increasingly used test strategies which target them prevent dementia. This review provides overview of experimental into 15 established putative factors: less early-life education, hearing loss, depression, social isolation, life stress, hypertension, obesity, diabetes, physical inactivity, heavy alcohol use, smoking, air pollution, anesthetic exposure, traumatic brain injury, disordered sleep. It explores how have been, can be, address questions about that cannot readily be addressed studies. HIGHLIGHTS: Modifiable Interrogation mechanisms is populations. Studies using diverse revealing mechanisms. We factors. Laboratory science contribute uniquely

Language: Английский

Citations

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