Association between ethylene oxide exposure and cognitive function in older adults from NHANES data

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 28, 2025

Language: Английский

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Investigating dynamic brain functional redundancy as a mechanism of cognitive reserve

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: Feb. 4, 2025

Introduction Individuals with higher cognitive reserve (CR) are thought to be more resilient the effects of age-related brain changes on performance. A potential mechanism CR is redundancy in network functional connectivity (BFR), which refers amount time spends a redundant state, indicating presence multiple independent pathways between regions. These can serve as back-up information processing routes, providing resiliency stress or disease. In this study we aimed investigate whether BFR modulates association and performance across broad range domains. Methods An open-access neuroimaging behavioral dataset ( n = 301 healthy participants, 18–89 years) was analyzed. Cortical gray matter (GM) volume, cortical thickness age, extracted from structural T1 images, served our measures life-course related (BC). Cognitive scores were principal component analysis performed 13 tests Multivariate linear regression tested modulating effect relationship Results PCA revealed three test components episodic, semantic executive functioning. Increased predicted reduced episodic functioning when considering GM volume BC. significantly modulated We found neither predictive nor performance, significant defining BC via age. Discussion Our results suggest that could metric certain domains, specifically functioning, defined dimensions findings potentially indicate underlying mechanisms CR.

Language: Английский

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Sex/gender differences in the clinical trajectory of Alzheimer’s disease: Insights into diagnosis and cognitive reserve

Frontiers in Neuroendocrinology, Journal Year: 2025, Volume and Issue: 77, P. 101184 - 101184

Published: Feb. 13, 2025

Language: Английский

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Augmenting Cognitive Function in the Elderly with Mild Cognitive Impairment Using Probiotic Lacticaseibacillus rhamnosus CBT-LR5: A 12-Week Randomized, Double-Blind, Parallel-Group Non-Comparative Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 691 - 691

Published: Feb. 14, 2025

Probiotics have been shown to enhance cognitive function in individuals with mild impairment (MCI), but their efficacy varies, depending on the strain and dosage. Clinical investigations are crucial confirm safety, efficacy, mechanism of action. This study was designed assess effective dosage, MH-Pro, a test product containing Lacticaseibacillus rhamnosus CBT-LR5 (LR5) skim milk (non-fat dry milk), improving related physiological changes older adults suspected MCI over 12 weeks. In total, 20 participants (mean age: 68.9 years) were randomly assigned 1:1 ratio either low-dose group (1 × 1010 CFU LR5 1622 mg) or high-dose 4055 mg milk) double-blind, parallel-group clinical trial. After weeks, showed significant improvements MOCA-K subdomains, specifically naming (p = 0.01) delayed recall 0.003). Additionally, levels amyloid-β1 40/42 blood significantly decreased 0.03) following supplementation group. The exhibited improvement orientation 0.05). Moreover, overall enhancement observed 0.003), while trend toward 0.06). Fecal analysis revealed bacterial composition, an increase after weeks MH-Pro consumption. Together, these findings provide foundational evidence suggesting that may serve as potential intervention for enhancing through gut-brain axis pathways elderly population. However, given small sample size predominance female participants, impact outcome be limited. Further large-scale studies necessary validate preliminary results. provides recognize use prepare probiotic supplement enhances aging

Language: Английский

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Sex differences in the association of Alzheimer’s disease biomarkers and cognition in a multicenter memory clinic study

Alzheimer s Research & Therapy, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 18, 2025

This study investigated sex differences in the associations between Alzheimer's disease (AD) biomarkers, cognitive performance, and decline memory clinic settings. 249 participants (females/males:123/126), who underwent tau-PET, amyloid-PET, structural MRI, plasma glial fibrillary acidic protein (GFAP) measurement were included from Geneva Lausanne Memory Clinics. Mann-Whitney U tests clinical biomarker data. Linear regression models estimated moderating effect of on relationship biomarkers performance decline. Sex further evaluated using longitudinal linear mixed-effect with three-way interaction effects. Women men present similar features, amyloid, neurodegeneration. had higher tau load levels GFAP than (p < 0.05). Tau amyloid (standardized β = 0.54,p 0.001), neurodegeneration β=-0.44,p cognition β=-0.48,p 0.001) moderated by a significant sex. Specifically, association was stronger among women β=-0.19,p 0.047), whereas β=-0.76,p 0.001 standardized β=-0.56,p 0.044). exhibited faster presence severe cortical thinning 0.001). showed men. In individuals high burden, greater impairment women. These findings support that may impact deposition through an upstream interplay leading to downstream effects outcomes.

Language: Английский

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Global burden of young-onset dementia, from 1990 to 2021: an age-period-cohort analysis from the global burden of disease study 2021

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 17, 2025

Language: Английский

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Investigating the Impact of NMDA Receptor Organization and Biological Sex in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1737 - 1737

Published: Feb. 18, 2025

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive decline, with women being disproportionately affected in both prevalence severity. A key feature of AD synaptic loss, particularly around amyloid-β (Aβ) aggregates, which correlates strongly the severity dementia. Oligomeric Aβ believed to be primary driver dysfunction impairing excitatory neurotransmission through interactions receptors, including N-methyl-D-aspartate (NMDA) receptors. However, influence sex on these changes NMDA receptor mislocalization not well understood. This study examined potential sex-specific differences synaptotoxicity role extrasynaptic GluN2B-containing receptors pathogenesis using APP/PS1 double transgenic mouse model. Although male female mice showed similar amyloid burden impairments, alterations were slightly less severe females, suggesting subtle pathology. Both sexes exhibited GluN2B subunits areas, was linked reduced PSD-95 levels accumulation Aβ1-42. Intrahippocampal injections DL-TBOA confirmed dysfunction. These findings emphasize importance targeting trafficking address AD-related deficits, potentially offering therapeutic approach for sexes.

Language: Английский

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Event-related potential markers of subjective cognitive decline and mild cognitive impairment during a sustained visuo-attentive task

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: 45, P. 103760 - 103760

Published: Jan. 1, 2025

Language: Английский

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CA3 Pyramidal Neuron Activation Promotes Cognitive Resilience to Inflammation‐Induced Cognitive Inflexibility

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Feb. 1, 2025

Cognitive dysfunction represents a prominent symptom in numerous prevalent mental illnesses, with systemic inflammation induced by cytokines recognized as critical factor contributing to cognitive impairments. However, significant proportion of individuals exposed do not develop dysfunction; instead, they exhibit adaptive responses this adverse condition. This study aims investigate the neural activity patterns within hippocampus and potential mechanisms that mediate resilience, particularly context inflammation. We investigated effects IL-1β (Interleukin-1β) on learning, spatial memory, flexibility using Barnes maze test (BMT). further analyzed specific changes mice exhibiting resilience versus susceptibility through immunofluorescence, fiber photometry, behavioral assessments. Additionally, we employed chemogenetic modulation explore role dCA3 pyramidal neurons inflexibility Systemic induces while leaving learning memory intact. Notably, was elevated cognitively resilient compared their susceptible counterparts. Fiber photometry data revealed higher dorsal CA3 (dCA3) when approached previous target quadrant during reversal stage BMT. Importantly, activation CaMKII+ mitigated administration. Activation hippocampal neurons, rather than dentate gyrus (DG) enhances improving BMT-related paradigm shifting under sustained

Language: Английский

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Sex-specific associations between serum lipid levels and cognitive performance in older adults: results from a cross-sectional real-world study

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: March 1, 2025

Abstract Aim Dyslipidemia and cognitive decline are prevalent in older adults, with their incidence increasing age. However, the relationship between serum lipid levels dysfunction geriatrics remains unclear, potentially influenced by sex differences. Methods This study evaluated functions adults using a large battery of neuropsychological tests. Dementia was staged Clinical Rating (CDR), classifying participants as cognitively healthy (CDR 0), mildly impaired 0.5), or dementia ≥ 1). Results The involved 1283 aged over 65 (466 men, 817 women; mean age 79.79 ± 5.93 years). Women had lower education levels, reduced autonomy activities daily living (ADL), but greater independence instrumental ADL. Additionally, women exhibited glucose higher total cholesterol (TC), high-density lipoprotein (HDL-C), low-density (LDL-C) compared to men. Subjects CDR 1 significantly poorer scores than those 0 0.5. No associations were found cognition group. In men 0, HDL-C positively correlated ACE-R Fluency. 0.5 group, TC linked better performance. For 1, associated improved Conclusion Elevated late-life may protect function individuals mild impairment, sex-specific impact dementia, beneficial for detrimental

Language: Английский

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