Dementia prevalence and dementia risk in Indigenous Peoples: recent findings, current developments, and future directions DOI
Joyla A. Furlano,

Maira Okada de Oliveira,

Maritza Pintado‐Caipa

et al.

Current Opinion in Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Purpose of review To highlight recent findings on the prevalence and risk protective factors for dementia in Indigenous Peoples, who are disproportionately affected by health inequities driven social determinants historical injustices. With increasing numbers individuals entering older age, there is a growing need research to better understand opportunities prevention Peoples. Recent studies wide range across with estimates varying significantly methodology, socio-cultural context, region stark gaps regional representation. Studies suggested that Peoples show distinct profiles factors, including higher rates cardiovascular disease, lower educational attainment, socioeconomic disadvantage. However, traditional lifestyles, strong ties, culturally grounded practices offer effects against cognitive decline. Summary Despite attention, significant limitations remain understanding The available evidence points sensitive approaches prevention, as well greater consideration environmental shaping brain health. Future should aim incorporate knowledge systems address

Language: Английский

Social determinants of health but not global genetic ancestry predict dementia prevalence in Latin America DOI Creative Commons
Jorge J. Llibre‐Guerra, Miao Jiang, Isaac Acosta

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(7), P. 4828 - 4840

Published: June 5, 2024

Leveraging the nonmonolithic structure of Latin America, which represents a large variability in social determinants health (SDoH) and high levels genetic admixture, we aim to evaluate relative contributions SDoH ancestry predicting dementia prevalence American populations.

Language: Английский

Citations

8
Sleep and Neurodegeneration: Examining Potential Physiological Mechanisms DOI
Brice V. McConnell, Yulin Deng, Brendan P. Lucey

et al.

Current Sleep Medicine Reports, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 3, 2025

Language: Английский

Citations

1
Embracing Ambiguity and Uncertainty: A Culturally Sensitive Approach to Dementia Care in Latinx Communities DOI Creative Commons
Juan Francisco Flores-Vázquez,

Rodrigo Gómez-Martínez,

Jordan F. Karp

et al.

Hispanic Journal of Behavioral Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Dementia in Latinx communities is increasingly prevalent and its approach complicated by systemic cultural barriers to care. In both Latin American countries immigrant communities, limited healthcare access, structural barriers, misconceptions hinder timely diagnosis treatment. Culturally sensitive care essential these contexts ensure that patients families are treated with dignity compassion, addressing their unique challenges perspectives on dementia. This paper discusses the philosophy of ambiguity medical uncertainty explore dementia’s complex realities, particularly underserved populations. Clinically, this includes dementia prognosis low- middle-income countries, bridging knowledge gaps building trust through culturally communication, recognizing impact ambiguous loss homeland for caregivers patients. Additionally, familism, mixed effects caregiving roles expectations, requires nuanced understanding. Embracing ambiguities fosters a more compassionate, goes beyond biomedical model acknowledges complexities living

Language: Английский

Citations

0
Ethnoracial disparities in gray matter atrophy are mediated by structural disconnectivity in multiple sclerosis DOI Creative Commons
Ahmed Bayoumi,

Joseph Thomas,

Breanna Alonzo

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Objective To investigate ethnoracial disparities in gray matter (GM) atrophy, the contribution of white lesions and consequent structural disconnectivity among patients with multiple sclerosis (MS). Methods This retrospective study included 297 MS (pwMS), 98 Hispanic/Latinx (H‐MS), 82 non‐Hispanic Black (B‐MS), 117 White (W‐MS). GM atrophy was assessed using univariate, voxel‐based morphometry, multivariate techniques, source‐based morphometry. Structural secondary to evaluated network modification tool. Mediation analyses explored relationships between groups, lesions, disconnectivity, atrophy. Results B‐MS H‐MS generally exhibited greater compared W‐MS, particularly temporal, parahippocampal, precuneus, cuneus GM. differences were most prominent hippocampal, cingulate, deep regions. revealed that lesion load significantly mediated group global (percent = 52.4%), while some specific components, notably matter, insular, anterior cingulate Interpretation Significant exist its patterns diverse patients, partially by disconnectivity. These findings underscore importance considering factors research clinical practice, potentially informing personalized treatment strategies emphasizing need for representation trials.

Language: Английский

Citations

0
Psychiatric genetics in the diverse landscape of Latin American populations DOI
Estela M. Bruxel, Diego Luiz Rovaris, Síntia Belangero

et al.

Nature Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

Citations

0
Environmental–genetic interactions in ageing and dementia across Latin America DOI
Agustín Ibáñez, Andrea Slachevsky

Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(10), P. 571 - 572

Published: July 12, 2024

Language: Английский

Citations

3
Higher socioeconomic deprivation in areas predicts cognitive decline in New Zealanders without cognitive impairment DOI Creative Commons
Susanne Röhr, Rosemary Gibson, Fiona Alpass

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 16, 2024

Previous studies identified individual-level socioeconomic factors as key determinants of cognitive health. This study investigated the effect area-based deprivation on outcomes in midlife to early late-life New Zealanders without impairment at baseline. Data stemmed from a subsample Zealand Health, Work and Retirement Study, cohort ageing, who completed face-to-face interviews were reassessed two years later. Cognitive functioning was measured using Addenbrooke's Examination–Revised, adapted for culturally acceptable use Aotearoa Zealand. Area-based assessed Deprivation Index (NZDep2006). Linear mixed-effects models analysed association between outcomes. The analysis included 783 participants baseline (54.7% female, mean age 62.7 years, 25.0% Māori, Indigenous people Zealand). There an higher lower (B = -0.08, 95%CI: -0.15;-0.01; p .050) decline -0.12, -0.20;-0.04, .013) over while controlling covariates. findings emphasise importance considering neighbourhood characteristics broader strategies aimed mitigating health disparities reducing impact dementia disadvantaged communities.

Language: Английский

Citations

0
Dementia prevalence and dementia risk in Indigenous Peoples: recent findings, current developments, and future directions DOI
Joyla A. Furlano,

Maira Okada de Oliveira,

Maritza Pintado‐Caipa

et al.

Current Opinion in Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Purpose of review To highlight recent findings on the prevalence and risk protective factors for dementia in Indigenous Peoples, who are disproportionately affected by health inequities driven social determinants historical injustices. With increasing numbers individuals entering older age, there is a growing need research to better understand opportunities prevention Peoples. Recent studies wide range across with estimates varying significantly methodology, socio-cultural context, region stark gaps regional representation. Studies suggested that Peoples show distinct profiles factors, including higher rates cardiovascular disease, lower educational attainment, socioeconomic disadvantage. However, traditional lifestyles, strong ties, culturally grounded practices offer effects against cognitive decline. Summary Despite attention, significant limitations remain understanding The available evidence points sensitive approaches prevention, as well greater consideration environmental shaping brain health. Future should aim incorporate knowledge systems address

Language: Английский

Citations

0