No effects of multi-modal intervention against cognitive decline on atrophy and small vessel disease imaging markers in the AgeWell.de imaging study DOI Creative Commons
Frauke Beyer,

Lukas Kleine,

Andrea Zülke

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Background Multimodal lifestyle interventions might help to maintain healthy cognition in older age and delay onset of dementia. Here, we studied the effects a multi-modal lifestyle-based intervention, based on FINGER trial, magnetic resonance imaging (MRI) markers hippocampal-limbic atrophy cerebral small vessel disease adults at increased risk for dementia Germany. Methods Leipzig participants multicenter AgeWell.de randomized controlled trial were examined with before after two year intervention 3 Tesla MRI. We extracted hippocampal volume entorhinal cortex thickness (ECT), free water fraction (FW), peak width skeletonized mean diffusivity (PSMD), white matter hyperintensity gray blood flow assessed effect these using linear mixed models. also tested hippocampus-dependent Mnemonic Similarity Test fixel-based microstructure. Results 56 individuals (mean(sd) age: 68.8 (4.2) years, 26 females, 24/32 intervention/control group) included baseline 41 returned an average 28 months second assessment. ECT FW exhibited stronger decline compared control group preregistered models but not when adjusted differences. All other progressed similarly across groups. In exploratory analyses, more this change was associated decreases systolic pressure. Conclusions dementia, did find hypothesized beneficial brain neurodegeneration disease. Yet, preliminary evidence suggested association pressure reductions. Trial registration German Clinical Trials Register (reference number DRKS00013555)

Language: Английский

Effects of a multidomain intervention against cognitive decline on dementia risk profiles — Results from the AgeWell.de trial DOI Creative Commons
Andrea Zülke, Alexander Pabst, Melanie Luppa

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(8), P. 5684 - 5694

Published: July 5, 2024

Abstract INTRODUCTION Dementia risk scores constitute promising surrogate outcomes for lifestyle interventions targeting cognitive function. We investigated whether dementia risk, assessed using the LIfestyle BRAin health (LIBRA) index, was reduced by AgeWell.de intervention. METHODS Secondary analyses of AgeWell trial, testing a multicomponent intervention (including optimization nutrition, medication, and physical, social, activity) in older adults with increased risk. analyzed data from n = 461 participants complete information on risk/protective factors comprised LIBRA at 24‐month follow‐up. Intervention effects components were generalized linear models. RESULTS The scores, indicating decreased follow‐up ( b –0.63, 95% confidence interval [CI]: –1.14, –0.12). particularly due to improvements diet (odds ratio [OR]: 1.60, CI: 1.16, 2.22) hypertension (OR: 1.61, 1.19, 2.18). DISCUSSION However, several did not improve, possibly requiring more intensive interventions. Highlights according scores. Beneficial are mainly changes blood pressure. A pragmatic is apt reduce an at‐risk population.

Language: Английский

Citations

6
Cost‐effectiveness of a multicomponent intervention against cognitive decline DOI Creative Commons
Christian Brettschneider,

Elżbieta Buczak‐Stec,

Melanie Luppa

et al.

Alzheimer s & Dementia Translational Research & Clinical Interventions, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 1, 2025

Abstract INTRODUCTION The societal costs of dementia and cognitive decline are substantial likely to increase during the next decades due increasing number people in older age groups. aim this multicenter cluster‐randomized controlled trial was assess cost‐effectiveness a multi‐domain intervention prevent who at risk for dementia. METHODS We used data from multi‐centric, two‐armed, ( AgeWell.de trial, ID: DRKS00013555). Eligible participants with increased baseline (Cardiovascular Risk Factors, Aging, Incidence Dementia/CAIDE Dementia Score ≥ 9), 60–77 years age, were recruited by their general practitioners, assigned randomly lifestyle or health advice. performed analysis perspective. time horizon 2 years. Health care utilization measured using “Questionnaire Health‐Related Resource Use Older Populations.” As effect measure, we quality‐adjusted life‐years (QALYs) based on 5‐level EQ‐5D version (EQ‐5D‐5L). calculated incremental ratios (ICER) acceptability curves (CEAC) net‐benefit approach. Exploratory analyses considering women EQ visual analogue scale (EQ VAS) conducted. RESULTS Data available 819 (mean 69.0 [standard deviation (SD)5‐level 4.9]); 378 treated group 441 control group. caused higher (+€445.88 [SD: €1,244.52]) gained additional effects (+0.026 QALY 0.020]) compared (the difference statistically significant). ICER €17,149.23/QALY. CEAC showed that probability being cost‐effective moderate, reaching 59% willingness‐to‐pay (WTP) €50,000/QALY. exploratory promising results, especially female subsample. DISCUSSION Considering aspects like WTP limited horizon, Highlights first German randomized (RCT) evaluating multicomponent approach against decline. found favorable ratio. reached 78.6%. Women could be an important target A longer is needed.

Language: Английский

Citations

0
Social functioning in individuals with Alzheimer's disease and the situation of caregivers DOI Creative Commons
Sophia Kraake, Melanie Luppa, Dorothee Saur

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Background Changes in social functioning may be a significant parameter for the early detection of Alzheimer's disease (AD). Currently, research on AD across entire spectrum is lacking. Objective The aim this study was to describe persons with at each stage and investigate how impaired affects caregiver burden. Methods Cross-sectional data derived from memory clinics Germany as part pilot “Social individuals situation caregivers”. A total N = 87 relatives providing care mild (n 20), moderate 40), severe 23) were included. Social measured via caregiver-rated German version Functioning Dementia Scale (SF-DEM); burden assessed using Zarit Caregiver Burden Interview (ZBI-12). Differences between mild, moderate, terms sociodemographic characteristics level examined. robust linear regression analysis conducted examine association Results lower than AD. Higher levels associated less Conclusions This highlights importance integrating assessments into clinical practice improving detection, diagnosis interventions Early enhance diminish

Language: Английский

Citations

0
Adherence to intervention components: The key to success? Analysis on health-related outcomes of the AgeWell.de intervention to preserve cognition DOI Creative Commons
Felix Wittmann, Alexander Pabst, Andrea Zülke

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Background The aim of the study was to analyze impact adherence intervention components on effectiveness AgeWell.de, a multi-domain lifestyle against cognitive decline, function in everyday activities, quality life, depressiveness and social isolation. Objective Studying effect health-related outcomes. Methods Participants were aged 60–77 years at baseline risk (Cardiovascular Risk Factors, Ageing Dementia Score (CAIDE) ≥9). Adherence nutrition, enhancement physical activities training analyzed two ways, first continual within group (n = 378, mean age 69.1 years, 52.7% female) second as dichotomous split (75% adherence) reference control (received infomaterial regular health advice; n 441, 69 53% female). Generalized linear regression models then run outcomes functioning depressive symptoms, inclusion. Results Health-related life improved participants with better nutritional counselling activities. Better relevant for Effects high found improvements when comparing it group. No inclusion considering particular components. Conclusions extent most influenced such depressiveness. With this study, AgeWell.de can be understood greater depth. Trial Registration German Clinical Register (DRKS; ID: DRKS00013555).

Language: Английский

Citations

0
Behaviour change techniques used in interventions targeting dementia risk factors amongst older adults in rural and remote areas: A systematic review and meta-analysis DOI Creative Commons
Laura Dodds, Kay Deckers, Celia B. Harris

et al.

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100093 - 100093

Published: Feb. 1, 2025

Language: Английский

Citations

0
Exploring the effect of multi-modal intervention against cognitive decline on atrophy and small vessel disease imaging markers in the AgeWell.de imaging study DOI Creative Commons
Frauke Beyer,

Lukas Kleine,

Andrea Zülke

et al.

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: unknown, P. 103796 - 103796

Published: May 1, 2025

Language: Английский

Citations

0
No effects of multi-modal intervention against cognitive decline on atrophy and small vessel disease imaging markers in the AgeWell.de imaging study DOI Creative Commons
Frauke Beyer,

Lukas Kleine,

Andrea Zülke

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Background Multimodal lifestyle interventions might help to maintain healthy cognition in older age and delay onset of dementia. Here, we studied the effects a multi-modal lifestyle-based intervention, based on FINGER trial, magnetic resonance imaging (MRI) markers hippocampal-limbic atrophy cerebral small vessel disease adults at increased risk for dementia Germany. Methods Leipzig participants multicenter AgeWell.de randomized controlled trial were examined with before after two year intervention 3 Tesla MRI. We extracted hippocampal volume entorhinal cortex thickness (ECT), free water fraction (FW), peak width skeletonized mean diffusivity (PSMD), white matter hyperintensity gray blood flow assessed effect these using linear mixed models. also tested hippocampus-dependent Mnemonic Similarity Test fixel-based microstructure. Results 56 individuals (mean(sd) age: 68.8 (4.2) years, 26 females, 24/32 intervention/control group) included baseline 41 returned an average 28 months second assessment. ECT FW exhibited stronger decline compared control group preregistered models but not when adjusted differences. All other progressed similarly across groups. In exploratory analyses, more this change was associated decreases systolic pressure. Conclusions dementia, did find hypothesized beneficial brain neurodegeneration disease. Yet, preliminary evidence suggested association pressure reductions. Trial registration German Clinical Trials Register (reference number DRKS00013555)

Language: Английский

Citations

0