A brain DNA co‐methylation network analysis of psychosis in Alzheimer's disease

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(2)

Published: Feb. 1, 2025

Abstract INTRODUCTION The presence of psychosis in Alzheimer's disease (AD) is suggested to be associated with distinct molecular and neuropathological profiles the brain. METHODS We assessed brain DNA methylation AD donors (AD+P) without (AD−P) using EPIC array. Weighted gene correlation network analysis identified modules co‐methylated genes a discovery cohort (PITT‐ADRC: N = 113 AD+P, 40 AD−P), validation an independent (BDR: 79 117 Gene Ontology cell‐type enrichment analysis. Genetic data were integrated identify quantitative trait loci (mQTLs), which co‐localized GWAS for related traits. RESULTS replicated one AD+P module, was enriched synaptic pathways excitatory inhibitory neurons. mQTLs this module variants schizophrenia educational attainment. DISCUSSION This represents largest epigenetic study date, identifying pleiotropic relationships between Highlights prefrontal cortex subjects AD−P. WGCNA six cohort. One mapping

Language: Английский

Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer's disease in the EMIF‐AD study

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

We investigated blood DNA methylation patterns associated with 15 well-established cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) pathophysiology, neuroinflammation, and neurodegeneration.

Language: Английский