Efficacy of Communication Bridge‐2 for primary progressive aphasia: A randomized controlled trial of communication intervention

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(3)

Published: March 1, 2025

Abstract INTRODUCTION Primary progressive aphasia (PPA), a language‐based neurodegenerative dementia, negatively impacts communication and quality of life. Previous non‐pharmacologic interventions show promise but lack efficacy trials. Here, outcomes are provided from Communication Bridge‐2 (CB2), speech‐language randomized controlled trial (RCT) for PPA. METHODS CB2 is the first Phase 2, Stage II, parallel‐group RCT delivered via video chat with global enrollment. Ninety‐five dyads were into one two intervention arms. included confidence participation measures. Marginal linear models assessed across ≈12 months. RESULTS four countries. Experimental arm superiority in communication‐participation measurement goal attainment was demonstrated (66.7% vs 49.1%, respectively, p = 0.006), corroborated by post‐study interviews. DISCUSSION Outcomes demonstrate feasibility initial person‐centered telemedicine maximizing mild‐to‐moderate PPA, providing pathway developing implementing clinically meaningful Alzheimer's disease related dementias. Highlights (PPA) participation. (CB2) telemedicine‐delivered (RCT). Global recruitment 95 PPA participant an low dropout. First international using shows efficacy. The study provides model rigorous trials disease/Alzheimer's dementias (AD/ADRD).

Language: Английский

Participatory Development of a Speech-Language Telerehabilitation Intervention combined with Home-based Transcranial Direct Current Stimulation for Primary Progressive Aphasia: a Qualitative Study

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Abstract Purpose Intensive speech-language therapy (SLT) delivered as telerehabilitation in combination with transcranial direct current stimulation (tDCS) may be an effective treatment option for people primary progressive aphasia (pwPPA). However, such combined approaches are technically challenging and feasibility pwPPA has not yet been established. We aimed to involve stakeholders the development of a novel approach combining remotely-supervised but independently self-administered home-based tDCS intensive (naming communicative-pragmatic therapy). Method Eight 16 caregivers participated two semi-structured interviews identify needs, preferences, perceived barriers challenges regard SLT, tDCS, all components. Based on results, step-by-step manual was developed tested by means usability tests follow-up involving four dyads. Interview data were transcribed analysed qualitatively quantitatively. Competency checklists used Results PwPPA their provided valuable insights into aspects planned programme. Overall, findings suggest high level acceptance need SLT tDCS. Using training, able perform more than half actions required needed assistance demanding To ensure feasibility, caregiver-assistance is support during interventions. Conclusions This mixed-methods study identified needs preferences telerehabilitation, well regarding demonstrate acceptability initial programmes. Our highlight importance stakeholder involvement intervention development, which will inform future optimisation technologically

Language: Английский