Cortical Diffusivity, a Biomarker for Early Neuronal Damage, Is Associated with Amyloid-β Deposition: A Pilot Study

Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 155 - 155

Published: Jan. 21, 2025

Pathological alterations in Alzheimer’s disease (AD) begin several years prior to symptom onset. Cortical mean diffusivity (cMD) may be used as a measure of early grey matter damage AD it reflects the breakdown microstructural barriers preceding volumetric changes and affecting cognitive function. We investigated cMD trajectory evaluated influence amyloid-β (Aβ) tau deposition. In this cross-sectional study, we analysed multimodal PET, DTI, MRI data 87 participants, stratified them into Aβ-negative -positive, cognitively normal, mildly impaired, patients. was significantly increased Aβ-positive MCI compared with CN frontal, parietal, temporal cortex, hippocampus, medial lobe. correlated cortical thickness only patients without Aβ deposition but not Our results suggest that is an marker neuronal since observed simultaneously subjects driven by tau, suggesting direct toxicity or associated inflammation causes neurons. provide information about before macrostructural changes.

Language: Английский

Association of cortical macrostructural and microstructural changes with cognitive performance and gene expression in subcortical ischemic vascular disease patients with cognitive impairment

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 222, P. 111239 - 111239

Published: Feb. 3, 2025

Previous researches have demonstrated that patients with subcortical ischemic vascular disease (SIVD) exhibited brain structure abnormalities. However, the cortical macrostructural and microstructural characteristics their relationship cognitive scores gene expression in SIVD remain largely unknown. This study collected 3D-T1 diffusion tensor imaging data from 30 impairment (SIVD-CI) 32 normal controls. The between-group comparative analyses of thickness, area, volume, local gyrification index (LGI), mean diffusivity (MD) were conducted a general linear model. Moreover, associations between significant neuroimaging values Allen Human Brain Atlas database evaluated using partial least squares regression correlation analysis. SIVD-CI showed decreases thicknesses across 18 regions, volumes three LGI five as well increases MD regions (P < 0.05). significantly reduced right insula, left superior temporal gyrus, central anterior caudal cingulate cortex, positively correlated different Furthermore, abnormal structural indicators found to be related nine risk genes (VCAN, APOE, EFEMP1, SALL1, BCAN, KCNK2, EPN2, DENND1B XKR6) specific damage may decline patients.

Language: Английский

Spatial and temporal patterns of cortical mean diffusivity in Alzheimer's disease and suspected non‐Alzheimer's disease pathophysiology

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(10), P. 7048 - 7061

Published: Aug. 12, 2024

Abstract INTRODUCTION The spatial and temporal patterns of cortical mean diffusivity (cMD), as well its association with Alzheimer's disease (AD) suspected non‐Alzheimer's pathophysiology (SNAP), are not yet fully understood. METHODS We compared baseline ( n = 617) longitudinal changes 421) cMD, thickness, gray matter volume their relations to vascular risk factors, amyloid beta (Aβ), tau positron emission tomography (PET), cognitive decline in Aβ PET negative positive older adults. RESULTS cMD increases were more sensitive detecting brain structural alterations than thinning atrophy. Tau‐related partially mediated Aβ‐related AD, whereas disease‐related increased levels substantially age‐related SNAP. DISCUSSION These findings revealed the dynamic microstructural macrostructural indicators associations AD SNAP, providing novel insights into understanding upstream downstream events neurodegenerative disease. Highlights Cortical (cMD) was factors. beta–related (AD). White hyperintensity–related higher mainly explained (SNAP). may assist tracking earlier signs

Language: Английский