Cerebrospinal Fluid Classical Biomarker Levels in Mixed vs. Pure A+T+ (A+T1+) Alzheimer’s Disease DOI Creative Commons
Ioanna Tsantzali,

Athanasia Athanasaki,

F. Boufidou

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2904 - 2904

Published: Dec. 20, 2024

Background: Alzheimer’s disease (AD) may present with pure (typical or atypical) and mixed phenotypes, sometimes causing difficulties in (differential) diagnosis. In order to achieve a diagnostic accuracy as high possible, the diagnosis of AD during life depends on various biomarkers, including cerebrospinal fluid (CSF) biomarkers. Methods: Classical CSF biomarkers were determined total 61 patients, classified both beta amyloid- tau-positive A+T+ (or A+T1+ according recently revised Alzheimer Association criteria for staging AD). Twenty one these patients fulfilled (mixed Lewy bodies, cerebrovascular disease, normal pressure hydrocephalus), whilst 40 had AD. Results: Patients did not differ respect gender, education, duration, cognitive status. After controlling confounding factors, no difference was observed between groups Aβ42 Aβ42/Aβ40 levels. Although by definition, abnormal (increased) levels phospho-tau181, group presented lower (less abnormal) phospho-tau181 tau compared group. Conclusions: comparable status, cases proteins and, if close cut-off values, uncertainty be increased.

Language: Английский

Remote cognitive tests predict neurodegenerative biomarkers in the Insight 46 cohort DOI Creative Commons
Martina Del Giovane, Valentina Giunchiglia,

Z. Ran Cai

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(2)

Published: Feb. 1, 2025

Abstract BACKGROUND Alzheimer's disease‐related biomarkers detect pathology years before symptoms emerge, when disease‐modifying therapies might be most beneficial. Remote cognitive testing provides a means of assessing early changes. We explored the relationship between neurodegenerative and cognition in cognitively normal individuals. METHODS remotely deployed 13 computerized Cognitron tasks 255 Insight 46 participants. generated amyloid load positivity, white matter hyperintensity volume (WMHV), whole brain hippocampal volumes at age 73, plus rates change over 2 years. examined Cognitron, biomarkers, standard neuropsychological tests. RESULTS Slower response time on delayed recognition task predicted positivity (odds ratio [OR] = 1.79, confidence interval [CI]: 1.15, 2.95), WMHV (1.23, CI: 1.00, 1.56). Brain atrophy correlated with poorer visuospatial performance ( b ‐0.42, ‐0.80, ‐0.05) accuracy immediate ‐0.01, ‐0.012, ‐0.001), respectively. Standard tests composites (rho 0.50, p < 0.001). DISCUSSION correlates supervised assessments holds potential for studying changes associated neurodegeneration. Highlights 70% Online cohort performed set remote online tasks. Response memory status (SUVR). Accuracy spatial span longitudinal rate. The can help identify AD‐related deficits.

Language: Английский

Citations

0
Cerebrospinal Fluid Classical Biomarker Levels in Mixed vs. Pure A+T+ (A+T1+) Alzheimer’s Disease DOI Creative Commons
Ioanna Tsantzali,

Athanasia Athanasaki,

F. Boufidou

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2904 - 2904

Published: Dec. 20, 2024

Background: Alzheimer’s disease (AD) may present with pure (typical or atypical) and mixed phenotypes, sometimes causing difficulties in (differential) diagnosis. In order to achieve a diagnostic accuracy as high possible, the diagnosis of AD during life depends on various biomarkers, including cerebrospinal fluid (CSF) biomarkers. Methods: Classical CSF biomarkers were determined total 61 patients, classified both beta amyloid- tau-positive A+T+ (or A+T1+ according recently revised Alzheimer Association criteria for staging AD). Twenty one these patients fulfilled (mixed Lewy bodies, cerebrovascular disease, normal pressure hydrocephalus), whilst 40 had AD. Results: Patients did not differ respect gender, education, duration, cognitive status. After controlling confounding factors, no difference was observed between groups Aβ42 Aβ42/Aβ40 levels. Although by definition, abnormal (increased) levels phospho-tau181, group presented lower (less abnormal) phospho-tau181 tau compared group. Conclusions: comparable status, cases proteins and, if close cut-off values, uncertainty be increased.

Language: Английский

Citations

0