Plasma protein risk scores for mild cognitive impairment and Alzheimer's disease in the Framingham heart study

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(3)

Published: March 1, 2025

Abstract INTRODUCTION It is unclear whether aggregated plasma protein risk scores (PPRSs) could be useful in predicting the risks of mild cognitive impairment (MCI) and Alzheimer's disease (AD). METHODS The Cox proportional hazard model with Least Absolute Shrinkage Selection Operator penalty was used to build PPRSs for MCI AD 1515 Framingham Heart Study Generation 2 1128 proteins measured at exam 5 (cognitively normal [CN] = 1258, 129, 128). RESULTS PPRS had a ratio (HR) 6.97 [5.34, 9.12], discriminating power (C‐index 82.52%). HR 5.74 [4.67, 7.05] 88.15%). Both were also significantly associated changes, brain atrophy, biomarkers. Proteins involved several pathways related leukocyte, chemotaxis, immunity, inflammation, cellular migration. DISCUSSION This study suggests that serve well predict developing as changes AD‐related pathogenesis brain. Highlights developed preclinical stage, MCI. loss volume, increasing level Leukocyte, migration enriched identified being PPRSs.

Language: Английский

Epidemiology of Head Injury and Associations with Clinical and Neuropsychological Test Scores in Older American Indians: Data from the Strong Heart Study

Journal of Racial and Ethnic Health Disparities, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Language: Английский

Vascular endothelial growth factor receptor-1 (FLT1) interactions with amyloid-beta in Alzheimer’s disease: a putative biomarker of amyloid-induced vascular damage

Neurobiology of Aging, Journal Year: 2024, Volume and Issue: 147, P. 141 - 149

Published: Dec. 25, 2024

We have identified FLT1 as a protein that changes during Alzheimer's disease (AD) whereby higher brain levels are associated with more amyloid, tau, and faster longitudinal cognitive decline. Given FLT1's role in angiogenesis immune activation, we hypothesized is upregulated response to amyloid pathology, driving vascular-immune cascade resulting neurodegeneration sought determine (1) if vivo (CSF plasma) associate biomarkers of AD neuropathology or differ between diagnostic staging an aged cohort enriched for early disease, (2) whether expression interacts on downstream outcomes, such phosphorylated tau performance. Additionally, replicate interactions the brain. The results showed CSF post-mortem tissue related increased particularly among positive individuals. These analyses help clarify potential utility biomarker individuals evidence amyloidosis.

Language: Английский