GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases DOI Creative Commons
Weijie Xie, Yuan Li, Xinyue Wang

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(5)

Published: April 16, 2025

ABSTRACT Gamma‐aminobutyric acid (GABA) B receptors (GABA Rs) that acts slowly and maintains the inhibitory tone are versatile regulators in complex nervous behaviors their involvement various neuropsychiatric disorders, such as anxiety, epilepsy, pain, drug addiction, Alzheimer's disease. Additional study advances have implied crucial roles of GABA Rs regulating feeding‐related behaviors, yet therapeutic potential addressing binge eating, disorders remains underutilized. This general review summarized physiological structure functions R, explored regulation psychiatric feeding metabolism fully discussed targeting its regulator‐binding sites for treatment different eating even obesity. While agonists directly bind to R1 some negative side effects, positive allosteric modulators (PAMs) R2 demonstrate excellent efficacy tolerability better safety indexes. Moreover, phosphorylation downstream may be novel targets Further studies, clinical trials particular, will essential confirming value PAMs other agents R pathways a setting.

Language: Английский

GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases DOI Creative Commons
Weijie Xie, Yuan Li, Xinyue Wang

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(5)

Published: April 16, 2025

ABSTRACT Gamma‐aminobutyric acid (GABA) B receptors (GABA Rs) that acts slowly and maintains the inhibitory tone are versatile regulators in complex nervous behaviors their involvement various neuropsychiatric disorders, such as anxiety, epilepsy, pain, drug addiction, Alzheimer's disease. Additional study advances have implied crucial roles of GABA Rs regulating feeding‐related behaviors, yet therapeutic potential addressing binge eating, disorders remains underutilized. This general review summarized physiological structure functions R, explored regulation psychiatric feeding metabolism fully discussed targeting its regulator‐binding sites for treatment different eating even obesity. While agonists directly bind to R1 some negative side effects, positive allosteric modulators (PAMs) R2 demonstrate excellent efficacy tolerability better safety indexes. Moreover, phosphorylation downstream may be novel targets Further studies, clinical trials particular, will essential confirming value PAMs other agents R pathways a setting.

Language: Английский

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