Transcriptome analysis of early‐ and late‐onset Alzheimer's disease in Korean cohorts DOI Creative Commons
Sang‐Won Han,

Jiyun Hwang,

Tamina Park

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(2)

Published: Feb. 1, 2025

Abstract INTRODUCTION The molecular mechanisms underlying early‐onset Alzheimer's disease (EOAD) and late‐onset (LOAD) remain incompletely understood, particularly in Asian populations. METHODS RNA‐sequencing was carried out on blood samples from 248 participants the Seoul National University Bundang Hospital cohort to perform differential gene expression (DGE) weighted co‐expression network analysis. Findings were replicated an independent Korean ( N = 275). RESULTS DGE analysis identified 18 88 dysregulated genes EOAD LOAD, respectively. Network a LOAD‐associated module showing significant enrichment pathways related mitophagy, 5′ adenosine monophosphate‐activated protein kinase signaling, ubiquitin‐mediated proteolysis. In replication cohort, downregulation of SMOX PLVAP LOAD replicated, highly preserved. addition, associated with brain amyloid beta deposition. DISCUSSION Our findings suggest distinct signatures for population, providing deeper understanding their diagnostic potential mechanisms. Highlights Analysis (LOAD), Expression levels downregulated LOAD. Pathways including mitophagy signaling enriched module. A preserved across two cohorts.

Language: Английский

Transcriptome analysis of early‐ and late‐onset Alzheimer's disease in Korean cohorts DOI Creative Commons
Sang‐Won Han,

Jiyun Hwang,

Tamina Park

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(2)

Published: Feb. 1, 2025

Abstract INTRODUCTION The molecular mechanisms underlying early‐onset Alzheimer's disease (EOAD) and late‐onset (LOAD) remain incompletely understood, particularly in Asian populations. METHODS RNA‐sequencing was carried out on blood samples from 248 participants the Seoul National University Bundang Hospital cohort to perform differential gene expression (DGE) weighted co‐expression network analysis. Findings were replicated an independent Korean ( N = 275). RESULTS DGE analysis identified 18 88 dysregulated genes EOAD LOAD, respectively. Network a LOAD‐associated module showing significant enrichment pathways related mitophagy, 5′ adenosine monophosphate‐activated protein kinase signaling, ubiquitin‐mediated proteolysis. In replication cohort, downregulation of SMOX PLVAP LOAD replicated, highly preserved. addition, associated with brain amyloid beta deposition. DISCUSSION Our findings suggest distinct signatures for population, providing deeper understanding their diagnostic potential mechanisms. Highlights Analysis (LOAD), Expression levels downregulated LOAD. Pathways including mitophagy signaling enriched module. A preserved across two cohorts.

Language: Английский

Citations

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