Decreased water exchange rate across the blood–brain barrier throughout the Alzheimer's disease continuum: Evidence from Chinese data DOI Creative Commons
Guanqun Chen, Hui Li, Xingfeng Shao

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(3)

Published: March 1, 2025

Abstract INTRODUCTION Water exchange rate (Kw) across the blood–brain barrier (BBB) is used in magnetic resonance imaging (MRI) techniques to evaluate BBB functionality. Variations Kw Alzheimer's disease (AD) continuum remain uncertain. METHODS The study encompassed 38 cognitively normal individuals without AD biomarkers (CN_A–), 30 (CN_A+), and 31 impaired (CI_A+) with positive biomarkers. Participants underwent clinical assessments, MRI/positron emission tomography scans, assays of plasma RESULTS Significantly lower was observed multiple brain regions throughout continuum. This alteration correlated neuropsychological performance. Elevated levels phosphorylated tau 217 intensified inverse relationship between integration Kw, volume, demonstrated potential distinguishing stages within DISCUSSION Consistently evident may act as a diagnostic tool for early screening. Highlights Observations revealed decline water continuum, notably hippocampus, parahippocampal gyrus, deep nuclei during preclinical stage AD. Strong correlations were established various biomarkers, well performance Interaction (p‐tau)217 hippocampus linked executive function, indicating combined detrimental impact on cognitive abilities stemming from both blood—brain p‐tau 217. use biomarkers—neurofilament light chain glial fibrillary acidic protein—demonstrated

Language: Английский

Decreased water exchange rate across the blood–brain barrier throughout the Alzheimer's disease continuum: Evidence from Chinese data DOI Creative Commons
Guanqun Chen, Hui Li, Xingfeng Shao

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(3)

Published: March 1, 2025

Abstract INTRODUCTION Water exchange rate (Kw) across the blood–brain barrier (BBB) is used in magnetic resonance imaging (MRI) techniques to evaluate BBB functionality. Variations Kw Alzheimer's disease (AD) continuum remain uncertain. METHODS The study encompassed 38 cognitively normal individuals without AD biomarkers (CN_A–), 30 (CN_A+), and 31 impaired (CI_A+) with positive biomarkers. Participants underwent clinical assessments, MRI/positron emission tomography scans, assays of plasma RESULTS Significantly lower was observed multiple brain regions throughout continuum. This alteration correlated neuropsychological performance. Elevated levels phosphorylated tau 217 intensified inverse relationship between integration Kw, volume, demonstrated potential distinguishing stages within DISCUSSION Consistently evident may act as a diagnostic tool for early screening. Highlights Observations revealed decline water continuum, notably hippocampus, parahippocampal gyrus, deep nuclei during preclinical stage AD. Strong correlations were established various biomarkers, well performance Interaction (p‐tau)217 hippocampus linked executive function, indicating combined detrimental impact on cognitive abilities stemming from both blood—brain p‐tau 217. use biomarkers—neurofilament light chain glial fibrillary acidic protein—demonstrated

Language: Английский

Citations

1