Annals of Neurology, Journal Year: 2023, Volume and Issue: 93(5)
Published: April 25, 2023
Wiley is a founding member of the UN-backed HINARI, AGORA, and OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries.
Language: Английский
Movement Disorders, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 3, 2024
Abstract Cognitive impairment is a well‐recognized and debilitating symptom of Parkinson's disease (PD). Degradation in the cortical cholinergic system thought to be key contributor. Both postmortem vivo positron emission tomography (PET) studies have provided valuable evidence changes PD, which are pronounced PD dementia (PDD). A growing body literature has employed magnetic resonance imaging (MRI), noninvasive, more cost‐effective alternative PET, examine structural PD. This review provides comprehensive discussion methodologies findings that focused on relationship between basal forebrain (cBF) integrity, based T1‐ diffusion‐weighted MRI, cognitive function Nucleus basalis Meynert (Ch4) volume been consistently reduced cognitively impaired samples shown potential utility as prognostic indicator for future decline. However, extent Ch4, especially early stages decline remains unclear. In addition, change anterior cBF regions not well established. underscores importance continued cross‐sectional longitudinal research elucidate role dysfunction manifestations © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC behalf International Parkinson Disorder Society.
Language: Английский
Citations
3
European Journal of Neurology, Journal Year: 2023, Volume and Issue: 31(2)
Published: Oct. 25, 2023
Abstract Background and purpose The specific pathophysiological mechanisms underlying postural instability/gait difficulty (PIGD) cognitive function in Parkinson's disease (PD) remain unclear. Both gait control, as well function, are associated with the cholinergic basal forebrain (cBF) system. Methods A total of 84 PD patients 82 normal controls were enrolled. Each participant underwent motor assessments. Diffusion tensor imaging was used to detect structural abnormalities cBF segmented using FreeSurfer, its fiber tract traced probabilistic tractography. To provide information on extracellular water accumulation, free‐water fraction (FWf) quantified. FWf tract, cortical projection density, extracted for statistical analyses. Results Patients had significantly higher ( p < 0.001) = 0.021) than controls, lower occipital 0.001), parietal prefrontal cortex 0.005). In patients, a correlated worse PIGD score r 0.306, 0.006) longer Trail Making Test time 0.303, 0.007). Attentional (Trail A) partially mediated association between (indirect effect, * b 0.071; c 0.256; 0.006). Conclusions Our findings suggest that degeneration system PD, from projection, plays an important role cognitive−motor interaction.
Language: Английский
Citations
7
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: July 17, 2024
Cognitive decline in Parkinson disease (PD) is a disabling and highly variable non-motor feature. While cholinergic systems degeneration linked to cognitive impairments PD, most prior research reported cross-sectional associations. We aimed fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ligand [
Language: Английский
Citations
2
Anesthesia & Analgesia, Journal Year: 2024, Volume and Issue: unknown
Published: June 11, 2024
Anesthesia induction and emergence are critical periods for perioperative safety in the clinic. Traditionally, from general anesthesia has been recognized as a simple inverse process of resulting elimination anesthetics central nervous system. However, accumulated evidence indicated that not mirror-image processes because occurrence hysteresis/neural inertia both animals humans. An increasing number studies have highlighted role orexinergic neurons their involved circuits selective regulation but anesthesia. Moreover, additional brain regions also implicated distinct neural mechanisms emergence, which extends concept anesthetic antiparallel processes. Here, we reviewed current literature summarized regarding differential mechanism modulation will facilitate understanding underlying
Language: Английский
Citations
1
Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 5, 2024
Language: Английский
Citations
1
Parkinsonism & Related Disorders, Journal Year: 2024, Volume and Issue: 121, P. 106031 - 106031
Published: Feb. 10, 2024
Language: Английский
Citations
0
Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 18, 2024
Abstract Parkinson's disease (PD) is the second‐fastest growing neurodegenerative in world. The major clinical symptoms rigor, tremor, and bradykinesia derive from degeneration of nigrostriatal pathway. However, PD a multi‐system disease, neurodegeneration extends beyond degradation dopaminergic Symptoms such as postural instability, freezing gait, falls, cognitive decline are predominantly caused by alterations transmitter systems outside classical axis. While levodopa deep brain stimulation (DBS) subthalamic nucleus or globus pallidus internus effectively address primary motor symptoms, they often fall short mitigating axial impairment. Along these lines, cholinergic system increasingly recognized to play crucial role governing locomotion, stability, function. Thus, there interest bolstering tone DBS targets pedunculopontine (PPN) basalis Meynert (NBM), aiming alleviate debilitating resistant traditional treatment strategies targeting network. This review offers comprehensive overview dysfunction PD. We discuss impact PPN NBM on management not readily accessible established pharmacotherapy seek provide guidance patient selection, surgical approach, paradigms. image
Language: Английский
Citations
0
Annals of Neurology, Journal Year: 2023, Volume and Issue: 93(5)
Published: April 25, 2023
Wiley is a founding member of the UN-backed HINARI, AGORA, and OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries.
Language: Английский
Citations
0