Exploratory Randomised Trial of Tranexamic Acid to Decrease Postoperative Delirium in Adults Undergoing Lumbar Fusion: A trial stopped early DOI Creative Commons
Bradley J. Hindman, Catherine R. Olinger, Royce W. Woodroffe

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Abstract Background Postoperative delirium may be mediated by perioperative systemic- and neuro-inflammation. By inhibiting the pro-inflammatory actions of plasmin, tranexamic acid (TXA) decrease postoperative delirium. To explore this hypothesis, we modified an ongoing randomised trial TXA, adding measures delirium, cognitive function, systemic cytokines, astrocyte activation. Methods Adults undergoing elective posterior lumbar fusion randomly received intraoperative intravenous TXA (n=43: 10 mg kg -1 loading dose, 2 h infusion) or Placebo (n=40). Blood was collected pre- at 24 post-operatively (n=32) for biomarkers inflammation (cytokines) activation (S100B). Participants had twice daily assessments using 3-minute diagnostic interview Confusion Assessment Method (n=65). underwent 4 function preoperatively during post-discharge follow-up. Results Delirium incidence in group (7/32=22%) not significantly less than (11/33=33%); P =0.408, absolute difference=11%, relative difference=33%, effect size = −0.258 (95% CI −0.744 to 0.229). In (n=16), severity associated with number instrumented vertebral levels ( =0.001) interleukin −8 −10 concentrations =0.00008 =0.005, respectively) these associations were TXA. group, S100B concentration =0.0009) strength association decreased =0.002). Conclusions A potential 33% justifies adequately powered clinical determine if decreases adults fusion.

Language: Английский

Geriatric nutritional risk index predicts postoperative delirium in elderly DOI Open Access

Siye Xie,

Qi Wu

Saudi Medical Journal, Journal Year: 2024, Volume and Issue: 45(9), P. 869 - 875

Published: Sept. 1, 2024

To review current evidence on using the geriatric nutritional risk index (GNRI) in predicting postoperative delirium (POD) elderly patients.

Language: Английский

Citations

0
PM2.5 is linked to Alzheimer’s syndrome and delirium: a mendelian randomization analysis DOI

Xiaojin Sun,

Xiaofan Yuan,

Haoyan Chen

et al.

International Journal of Clinical and Experimental Pathology, Journal Year: 2024, Volume and Issue: 17(9), P. 308 - 315

Published: Jan. 1, 2024

Increasing air pollution has drawn our attention to particulate matter (PM2.5), which been shown correlate significantly with respiratory and cardiovascular systems. However, whether PM2.5 is causally associated Alzheimer's syndrome or delirium unclear.

Language: Английский

Citations

0
Brain health DOI Creative Commons
Vincent Bonhomme, Christian Putensen, Bernd W. Böttiger

et al.

European Journal of Anaesthesiology Intensive Care, Journal Year: 2024, Volume and Issue: 3(6), P. e0063 - e0063

Published: Oct. 4, 2024

Damage to the brain can have disastrous and long-lasting consequences. The European Society of Anaesthesiology Intensive Care (ESAIC) is aware importance taking good care brain, both patients anaesthesia intensive unit (ICU) caregivers, has organised a complete learning track on health bring this concern attention practitioners. This included an online Focus Meeting Brain Health (November 25, 2023). We here provide readers with digest information that was delivered during meeting in opinion paper driven by authors' own reading literature. It divided according meeting's sessions, including how improve injured keep young or old healthy, healthy adult unimpaired, monitoring impact operating room unit, ICU caregivers' healthy. Each part brief focused summary. main messages are management involves adequate choice sedation, monitoring, specific points depending underlying pathology; several measures be undertaken protect very needing anaesthesia; it possible detect older at risk postoperative neurocognitive disorders, dedicated perioperative multidisciplinary expert team may their outcomes; apparently brains suffer electroencephalogram peri-operative dysfunction, female should given special respect; multimodal helps pathological processes maintain homeostasis; burnout anaesthesiologists effectively fought using personal, organisational, managerial legal approaches.

Language: Английский

Citations

0
The Safety of Alcohol Pharmacotherapies in Pregnancy: A Scoping Review of Human and Animal Research DOI Creative Commons
Ebony Quintrell, Danielle J. Russell, Sofa Rahmannia

et al.

CNS Drugs, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Alcohol pharmacotherapies pose unknown teratogenic risks in pregnancy and are therefore recommended to be avoided. This limits treatment options for pregnant individuals with alcohol use disorders (AUD). The information on the safety of these medications during is uncertain, prompting a scoping review. objective this review was investigate available pregnancy.

Language: Английский

Citations

0
Exploratory Randomised Trial of Tranexamic Acid to Decrease Postoperative Delirium in Adults Undergoing Lumbar Fusion: A trial stopped early DOI Creative Commons
Bradley J. Hindman, Catherine R. Olinger, Royce W. Woodroffe

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Abstract Background Postoperative delirium may be mediated by perioperative systemic- and neuro-inflammation. By inhibiting the pro-inflammatory actions of plasmin, tranexamic acid (TXA) decrease postoperative delirium. To explore this hypothesis, we modified an ongoing randomised trial TXA, adding measures delirium, cognitive function, systemic cytokines, astrocyte activation. Methods Adults undergoing elective posterior lumbar fusion randomly received intraoperative intravenous TXA (n=43: 10 mg kg -1 loading dose, 2 h infusion) or Placebo (n=40). Blood was collected pre- at 24 post-operatively (n=32) for biomarkers inflammation (cytokines) activation (S100B). Participants had twice daily assessments using 3-minute diagnostic interview Confusion Assessment Method (n=65). underwent 4 function preoperatively during post-discharge follow-up. Results Delirium incidence in group (7/32=22%) not significantly less than (11/33=33%); P =0.408, absolute difference=11%, relative difference=33%, effect size = −0.258 (95% CI −0.744 to 0.229). In (n=16), severity associated with number instrumented vertebral levels ( =0.001) interleukin −8 −10 concentrations =0.00008 =0.005, respectively) these associations were TXA. group, S100B concentration =0.0009) strength association decreased =0.002). Conclusions A potential 33% justifies adequately powered clinical determine if decreases adults fusion.

Language: Английский

Citations

0