GeroScience, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 30, 2024
Language: Английский
Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(9), P. 101735 - 101735
Published: Sept. 1, 2024
Language: Английский
Citations
8
The American Journal of Human Genetics, Journal Year: 2024, Volume and Issue: 111(2), P. 259 - 279
Published: Jan. 21, 2024
Language: Английский
Citations
7
Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(5)
Published: May 1, 2025
Abstract INTRODUCTION In Alzheimer's disease (AD), fibrillar tau gradually progresses from initial seed to larger brain area. However, those properties underlying the region‐dependent susceptibility accumulation remain unclear. METHODS We constructed multimodal spatial gradients characterize molecular and connectomic architecture. A predictive model for regional deposition was developed by integrating embeddings in principal of global connectome with gene expression, neurotransmitters, myelin, amyloid‐beta. The trained on amyloid‐beta–positive participants Disease Neuroimaging Initiative (ADNI) externally validated independent datasets. RESULTS combination explained up 77.7% cross‐sectional 77.3% longitudinal inter‐regional variance deposition. Gene set enrichment analysis a major expression gradient points synaptic transmission confer increased tau. DISCUSSION Our findings reveal spatially heterogeneous landscape shaping deposition, presenting powerful system‐level explanatory pathology AD. Highlights Spatial fundamental associated pathology. power showed high consistency across studies. Genetic analyses suggested that synapse plays vital role accumulation.
Language: Английский
Citations
0
Current Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 20(7), P. 538 - 556
Published: Aug. 29, 2024
Background: This study investigates the application of polyamidoamine (PAMAM) dendrimers as an innovative drug delivery approach for enhancing pharmacokinetic profile ursolic acid (UA), a pentacyclic triterpenoid with multifaceted therapeutic properties. UA, sourced from plants like Sanguisorba officinalis and Salvia officinalis, has been extensively studied its pharmacological characteristics, including anti-inflammatory, antioxidant, anti-diabetic properties, recognized in Traditional Chinese Medicine (TCM). The clinical utility UA is hampered by low bioavailability, which attributed to hydrophobic nature. To address this limitation, we explore use PAMAM dendrimers, known their potential. Methods: UA-PAMAM G0 were synthesized varying molar ratios. Characterization included size analysis, PDI, zeta potential determination. FTIR confirmed chemical structure. Male SD rats acclimatized administered control suspension UA-G0 dendrimer complex orally. Blood samples collected analysis. obtained IAEC approval. Results: complexes exhibited sizes based on ratios, 2:1 ratio showing significantly smaller dimensions. successful conjugation. In study, demonstrated higher plasma concentrations than alone, indicated increased Cmax AUC values. results suggest enhanced oral bioavailability complex. Conclusion: synthesis variations analysis revealed improved compared alone. These findings highlight compounds bridging gap between traditional herbal medicine modern strategies. Further research can broader applications such systems.
Language: Английский
Citations
0
GeroScience, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 30, 2024
Language: Английский
Citations
0