Neuroimaging Predictors of Cognitive Resilience against Alzheimer's Disease Pathology
Annals of Neurology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Some
individuals
demonstrate
greater
cognitive
resilience-the
ability
to
maintain
performance
despite
adverse
brain-related
changes-through
as
yet
unknown
mechanisms.
We
examined
whether
cortical
thickness
in
several
brain
regions
confers
resilience
against
decline
amyloid-positive
adults
by
moderating
the
effects
of
thinner
cortex
Alzheimer's
disease
(AD)-related
and
higher
levels
tau.
Amyloid-positive
participants
from
Disease
Neuroimaging
Initiative
with
relevant
imaging
data
were
included
(n
=
160,
observations
473).
Risk
factors
an
AD
signature
cerebrospinal
fluid
phosphorylated
Cognitive
measures
episodic
memory
executive
function
composites.
Mixed
models
tested
region-specific
moderated
relationships
between
markers
risk
or
function.
Cross-sectionally,
thicker
8
minimized
negative
impact
cortex/smaller
volume
on
Longitudinally,
baseline
a
composite
these
predicted
less
(p
0.007)
weakened
tau
0.014),
independent
cognition
markers.
identified
that
appear
confer
cross-sectionally
longitudinally
face
established
indicators
pathology.
Brain
fostering
may
enable
compensation
later
AD-related
changes.
These
"resilience"
suggest
value
focusing
beyond
only
those
determined
be
partially
explain
variability
trajectories.
ANN
NEUROL
2025.
Language: Английский
Association of 24 h-movement behaviors with cerebral and hippocampal amyloid beta levels and executive function in cognitively normal older adults: a compositional data analysis from the AGUEDA trial
Journal of science and medicine in sport,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Language: Английский