Genetic Etiology Influences the Low‐Frequency Components of Globus Pallidus Internus Electrophysiology in Dystonia DOI Creative Commons
Ahmet Kaymak, Luigi Romito, Fabiana Colucci

et al.

European Journal of Neurology, Journal Year: 2025, Volume and Issue: 32(3)

Published: March 1, 2025

Elevated low-frequency activity (4-12 Hz) within the globus pallidus internus (GPi) has been consistently associated with dystonia. However, impacts of genetic etiology dystonia on GPi remain unclear; yet it holds importance for adaptive deep brain stimulation (DBS) treatment. We compared properties electrophysiology acquired from 70 microelectrode recordings (MER) trajectories DYT-GNAL, DYT-KMT2B, DYT-SGCE, DYT-THAP1, DYT-TOR1A, DYT-VPS16, and idiopathic (iDYT) patients who underwent GPi-DBS surgery across standard frequency bands. DYT-SGCE exhibited significantly lower alpha band (2.97%) to iDYT (4.44%, p = 0.006) DYT-THAP1 (4.51%, 0.011). Additionally, theta power was also reduced in (4.42%) (7.91% 7.00%, < 0.05). Instead, did not affect spatial characteristics along MER trajectories. Considering closed-loop DBS treatments utilizing may optimize clinical outcomes. MER-based lead placement can proceed independently underlying cause.

Language: Английский

Genetic Etiology Influences the Low‐Frequency Components of Globus Pallidus Internus Electrophysiology in Dystonia DOI Creative Commons
Ahmet Kaymak, Luigi Romito, Fabiana Colucci

et al.

European Journal of Neurology, Journal Year: 2025, Volume and Issue: 32(3)

Published: March 1, 2025

Elevated low-frequency activity (4-12 Hz) within the globus pallidus internus (GPi) has been consistently associated with dystonia. However, impacts of genetic etiology dystonia on GPi remain unclear; yet it holds importance for adaptive deep brain stimulation (DBS) treatment. We compared properties electrophysiology acquired from 70 microelectrode recordings (MER) trajectories DYT-GNAL, DYT-KMT2B, DYT-SGCE, DYT-THAP1, DYT-TOR1A, DYT-VPS16, and idiopathic (iDYT) patients who underwent GPi-DBS surgery across standard frequency bands. DYT-SGCE exhibited significantly lower alpha band (2.97%) to iDYT (4.44%, p = 0.006) DYT-THAP1 (4.51%, 0.011). Additionally, theta power was also reduced in (4.42%) (7.91% 7.00%, < 0.05). Instead, did not affect spatial characteristics along MER trajectories. Considering closed-loop DBS treatments utilizing may optimize clinical outcomes. MER-based lead placement can proceed independently underlying cause.

Language: Английский

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