Advances in cardiac organoid technology: current trends and standardized quality assessment for toxicity testing in preclinical models DOI Creative Commons
S. Lee, Hyang‐Ae Lee

Organoid, Journal Year: 2024, Volume and Issue: 4, P. e6 - e6

Published: June 25, 2024

Cardiotoxicity is a prominent cause of drug withdrawal, impacting development during preclinical and clinical phases, as well post-market approval. Traditional 2-dimensional cell culture models, despite being resource-rich, suffer from suboptimal physiological environment. Animal models provide an in vivo setting; however, their use declining due to interspecies variability ethical concerns. Cardiac organoids, which are derived human induced pluripotent stem cells, incorporate genetic information contain various types within 3-dimensional environment that mimics the heart. As result, they becoming increasingly popular for testing. To effectively cardiac organoids standardized quality assessment crucial. This review discusses current trends organoid generation examines recent analytical techniques assessment.

Language: Английский

Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management DOI Creative Commons
Hunkyu Seo, Won Gi Chung, Yong Won Kwon

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(19), P. 11488 - 11558

Published: Sept. 25, 2023

The eye contains a complex network of physiological information and biomarkers for monitoring disease managing health, ocular devices can be used to effectively perform point-of-care diagnosis management. This comprehensive review describes the target various diseases, including ophthalmic metabolic neurological based on anatomical background eye. also includes recent technologies utilized in eye-wearable medical latest trends wearable devices, specifically smart contact lenses purpose After introducing other such as retinal prosthesis, we further discuss current challenges potential possibilities lenses.

Language: Английский

Citations

59
Material and structural considerations for high-performance electrodes for wearable skin devices DOI Creative Commons
Kyeonghee Lim, Hunkyu Seo, Won Gi Chung

et al.

Communications Materials, Journal Year: 2024, Volume and Issue: 5(1)

Published: April 11, 2024

Abstract Wearable skin-contacting devices are extensively studied for their ability to provide convenient and safe health monitoring. A key aspect that controls performance the properties of device electrodes. Optimizing electrode structure, materials they made from, can improve functionality. Here, we discuss various required optimal performance, including mechanical, electrical, biocompatible factors. To address these challenges, consider alteration development flexible or soft conductive materials, creation hybrid structures. Additionally, integration artificial intelligence is proposed as a promising direction achieve smart devices. As well outlining essential characteristics high-performance wearable skin also offer insight into possible future applications.

Language: Английский

Citations

16
Electrical stimulation for therapeutic approach DOI Creative Commons
Enji Kim, Sumin Kim, Yong Won Kwon

et al.

Deleted Journal, Journal Year: 2023, Volume and Issue: 1(2)

Published: April 1, 2023

Abstract Electrical stimulation as a therapeutic approach is widely applicable in terms of target tissues or effects. This method can be an alternative to conventional therapies for patients who are resistant drugs ineligible surgical operations. In addition, researchers have actively studied how adjust the parameters electrical order improve effectiveness, many already received treatments with stimulation. With respect devices stimulation, recent studies focused on developing reliability safe and long‐term From point view engineers, comprehensive understanding modulates biological system essential develop advanced strategies that provide effective results. Herein, fundamental mechanisms delivering reviewed along requirements need qualified by electrodes. Furthermore, latest advances discussed followed introduction representative applications

Language: Английский

Citations

27
Humanized brain organoids-on-chip integrated with sensors for screening neuronal activity and neurotoxicity DOI
Pelin Sağlam-Metiner, Ender Yıldırım, Can Dincer

et al.

Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(1)

Published: Jan. 1, 2024

Language: Английский

Citations

10
Ga‐Based Liquid Metals: Versatile and Biocompatible Solutions for Next‐Generation Bioelectronics DOI Open Access
Won Gi Chung, Enji Kim, Yong Won Kwon

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(31)

Published: Dec. 6, 2023

Abstract The utilization of gallium (Ga)‐based liquid metals (LMs) as functional materials in bioelectronics has been extensively explored over the past decade a key to stimulation biological systems and recording signals. motivation behind this class electronics is driven by opportunities exploit mechanical properties similar tissues. These bioelectronic devices are required maintain functionality under deformation and, especially for implantable applications, should interface with tissues minimally invasive manner. LMs attractive such applications due their ability deform while retaining electrical conductivity. Furthermore, unlike most liquids that form droplets minimize surface energy, ultrathin solid‐state oxide layer on outer enables them be shaped specific 3D patterns. Unlike mercury, Ga‐based considered biocompatible low toxicity vapor pressure, highlighting potential advantageous bioelectronics. This review comprehensively presents fundamental aspects these materials, focus effectiveness stimulating tissues, well diverse soft stretchable electrodes Additionally, investigates additional strategies aimed at driving future advancements field.

Language: Английский

Citations

16
Biocompatible Electronic Skins for Cardiovascular Health Monitoring DOI

Yucong Du,

Ji Hong Kim,

Hui Kong

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(16)

Published: April 3, 2024

Cardiovascular diseases represent a significant threat to the overall well-being of global population. Continuous monitoring vital signs related cardiovascular health is essential for improving daily management. Currently, there has been remarkable proliferation technology focused on collecting data through electronic skin monitoring. However, concerns have arisen regarding potential irritation and inflammation due necessity prolonged wear wearable devices. To ensure comfortable uninterrupted monitoring, concept biocompatible gained substantial attention. In this review, skins are comprehensively summarized discussed. The recent achievements in introduced. Their working principles, fabrication processes, performances sensing technologies, materials, integration systems highlighted, comparisons made with other used addition, significance integrating updating wireless communication development smart medical field explored. Finally, opportunities challenges also examined.

Language: Английский

Citations

6
3D Spatiotemporal Activation Mapping of Cardiac Organoids Using Conformal Shell Microelectrode Arrays (MEAs) DOI Creative Commons
Deok‐Ho Kim, Soo Jin Choi,

Z. Liu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Abstract Cardiac organoids have emerged as transformative models for investigating cardiogenesis and cardiac diseases. While traditional 2D microelectrode arrays (MEAs) been used to assess the functionality of organoids, they are limited electrophysiological measurements from a single plane do not capture 3D propagation electrical signals. Here, we present programmable, shape-adaptive shell MEA designed map activity across entire surface organoids. These MEAs fabricated on-chip, with tunable dimensions electrode layout, enabling precise encapsulation spherical Using MEAs, generated isochrone maps conduction velocity vectors, revealing speed trajectory signal in spontaneously beating The optical transparency allowed simultaneous calcium imaging, validating pattern. To demonstrate their utility cardiotoxicity screening, monitored changes treated isoproterenol E-4031 over nine days. We anticipate that combined spatiotemporal mapping, can significantly advance development spatially organized structural disease models, high-throughput drug screening platforms.

Language: Английский

Citations

0
Advancing Brain Organoid Electrophysiology: Minimally Invasive Technologies for Comprehensive Characterization DOI Creative Commons
Mujeeb Yousuf, Jean‐Christophe Rochet, Pushpapraj Singh

et al.

Advanced Materials Technologies, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Abstract Human brain organoids, which originate from pluripotent stem cells, serve as valuable tools for a wide range of research endeavors, replicating function. Their capacity to replicate cellular interactions, morphology, and division provides invaluable insights into development, disease modeling, drug screening. However, conventional morphological analysis methods are often invasive lack real‐time monitoring capabilities, posing limitations achieving comprehensive understanding. Therefore, advancing the comprehension organoid electrophysiology necessitates development minimally measurement technologies with long‐term, high‐resolution capabilities. This review highlights significance human organoids emphasizes need electrophysiological characterization. It delves assessment methods, particularly focusing on 3D microelectrode arrays, electrode insertion mechanisms, importance flexible arrays facilitate recordings. Additionally, various sensors tailored monitor properties introduced, enriching understanding their chemical, thermal, mechanical dynamics.

Language: Английский

Citations

0
Cyborg organoids integrated with stretchable nanoelectronics can be functionally mapped during development DOI
Zuwan Lin, Wenbo Wang, Ren Liu

et al.

Nature Protocols, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

Citations

0
Materials and Structural Designs for Neural Interfaces DOI
Sumin Kim, Yong Won Kwon, Hunkyu Seo

et al.

ACS Applied Electronic Materials, Journal Year: 2023, Volume and Issue: 5(4), P. 1926 - 1946

Published: March 27, 2023

Rapid advances in neurotechnology enable bidirectional communication between the nervous system and engineered devices. The precise recording stimulation of typical target neurons by neural interfaces with adequate materials structures can provide revolutionized medical applications, including diagnosis treatment neurological disorders. Thereby, a proper understanding electronic device its interfacing biological surroundings is necessary. Here, this review highlights basic concepts signaling, recording, to help understand interfaces. Then, we summarize considerations introduce variety that satisfy requirements. Furthermore, key challenges for next-generation are considered, future directions explored based on recent studies.

Language: Английский

Citations

10