Inversely engineered biomimetic flexible network scaffolds for soft tissue regeneration

Science Advances, Journal Year: 2023, Volume and Issue: 9(39)

Published: Sept. 27, 2023

Graft-host mechanical mismatch has been a longstanding issue in clinical applications of synthetic scaffolds for soft tissue regeneration. Although numerous efforts have devoted to resolve this grand challenge, the regenerative performance existing remains limited by slow growth (comparing autograft) and failures. We demonstrate class rationally designed flexible network that can precisely replicate nonlinear responses tissues enhance regeneration via reduced graft-host mismatch. Such scaffold includes tubular frame containing inversely engineered curved microstructures produce desired properties, with an electrospun ultrathin film wrapped around offer proper microenvironment cell growth. Using rat models sciatic nerve defects or Achilles tendon injuries, our show performances evidently superior clinically approved conduit achieve similar outcomes autologous transplantation prevention target organ atrophy recovery static index.

Language: Английский

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Hybrid polymeric scaffolds for potential applications in nerve and muscle regeneration

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 359 - 393

Published: Jan. 1, 2025

Language: Английский

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Stimuli-responsive biomedical polymeric films for tissue regeneration

Microstructures, Journal Year: 2025, Volume and Issue: 5(3)

Published: April 23, 2025

Tissue damage poses a significant burden on patients’ daily lives and has long driven the search for effective clinical treatments. Recent decades have witnessed development of smart biomedical materials satisfying specific requirements such as irregular shapes dynamic microenvironments at defective sites. Stimuli-responsive polymeric films are well-positioned to play considerable role in exploitation next-generation biomaterials both soft hard tissue regeneration. These can be fabricated through diverse approaches engineered with versatile structures properties. Furthermore, responsive stimuli temperature, water, light, these exhibit well-designed functions shape adaption, controlled drug release, cell adhesion vivo , effectively improving In this work, we review recent advancements stimuli-responsive films, beginning introduction their fabrication methods. Subsequently, mechanisms discussed scrutinized terms structure property variations. An overview applications regeneration, including skin, cardiovascular, nerve, bone is provided. Finally, further discuss benefits limitations practical applications, proposing our expectations perspectives future films.

Language: Английский

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3D Bioprinting Strategies for Melatonin‐Loaded Polymers in Bone Tissue Engineering

Macromolecular Materials and Engineering, Journal Year: 2024, Volume and Issue: 310(1)

Published: Oct. 30, 2024

Abstract Bone pathologies are still among the most challenging issues for orthopedics. Over past decade, different methods developed bone repair. In addition to advanced surgical and graft techniques, polymer‐based biomaterials, bioactive glass, chitosan, hydrogels, nanoparticles, cell‐derived exosomes used healing strategies. Owing their variation promising advantages, of these not translated into clinical practice. Three dimensonal (3D) bioprinting is an additive manufacturing technique that has become a next‐generation biomaterial adapted anatomic modeling, artificial tissue or organs, grafting, bridging tissues. Polymer‐based biomaterials mostly controlled release various drugs, therapeutic agents, mesenchymal stem cells, ions, growth factors. Polymers now preferable materials 3D bioprinting. Melatonin well‐known antioxidant with many osteoinductive properties one key hormones in brain–bone axis. bioprinted melatonin‐loaded polymers unique lipophilic, anti‐inflammatory, antioxidant, filling large gaps following fractures congenital deformities may be future. This study summarized benefits polymeric integrated melatonin sustained regeneration approaches.

Language: Английский

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Advanced Polymeric Membranes as Biomaterials Based on Marine Sources Envisaging the Regeneration of Human Tissues

Gels, Journal Year: 2023, Volume and Issue: 9(3), P. 247 - 247

Published: March 20, 2023

The self-repair capacity of human tissue is limited, motivating the arising engineering (TE) in building temporary scaffolds that envisage regeneration tissues, including articular cartilage. However, despite large number preclinical data available, current therapies are not yet capable fully restoring entire healthy structure and function on this when significantly damaged. For reason, new biomaterial approaches needed, present work proposes development characterization innovative polymeric membranes formed by blending marine origin polymers, a chemical free cross-linking approach, as biomaterials for regeneration. results confirmed production polyelectrolyte complexes molded membranes, with structural stability resulting from natural intermolecular interactions between biopolymers collagen, chitosan fucoidan. Furthermore, presented adequate swelling ability without compromising cohesiveness (between 300 600%), appropriate surface properties, revealing mechanical properties similar to native From different formulations studied, ones performing better were produced 3 % shark 3% 10% fucoidan, well 5% jellyfish Overall, novel demonstrated have promising chemical, physical approaches, namely thin can be applied over damaged cartilage aiming its

Language: Английский

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Cell Therapy and Biomaterials: Modern Approaches in the Treatment of Spinal Cord Injury

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(S1), P. S23 - S49

Published: Dec. 1, 2024

Language: Английский

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