ChemSusChem,
Journal Year:
2018,
Volume and Issue:
11(22), P. 3911 - 3916
Published: Oct. 5, 2018
Abstract
A
transition‐metal‐catalyzed
borrowing
hydrogen/hydrogen
auto‐transfer
strategy
allows
the
utilization
of
feedstock
alcohols
as
an
alkylating
partner,
which
avoids
formation
stoichiometric
salt
waste
and
enables
a
direct
benign
approach
for
construction
C‐N
C−C
bonds.
In
this
study,
nickel‐catalyzed
α‐alkylation
unactivated
amides
ester
(
tert
‐butyl
acetate)
is
carried
out
by
using
primary
under
mild
conditions.
This
bond‐forming
reaction
catalyzed
new,
molecularly
defined
nickel(II)
NNN‐pincer
complex
(0.1–1
mol
%)
proceeds
through
hydrogen
auto‐transfer,
thereby
releasing
water
sole
byproduct.
addition,
N
‐alkylation
cyclic
Ni‐catalytic
conditions
demonstrated.
ChemSusChem,
Journal Year:
2019,
Volume and Issue:
12(11), P. 2345 - 2349
Published: April 8, 2019
A
general
and
efficient
iron-catalyzed
C-alkylation
of
oxindoles
has
been
developed.
This
borrowing
hydrogen
approach
employing
a
(cyclopentadienone)iron
carbonyl
complex
(2
mol
%)
exhibited
broad
reaction
scope,
allowing
benzylic
simple
primary
secondary
aliphatic
alcohols
to
be
employed
as
alkylating
agents.
variety
underwent
selective
mono-C3-alkylation
in
good-to-excellent
isolated
yields
(28
examples,
50-92
%
yield,
79
average
yield).
ChemCatChem,
Journal Year:
2019,
Volume and Issue:
11(4), P. 1167 - 1174
Published: Jan. 2, 2019
Abstract
Olefins
are
essential
building
blocks
in
organic
synthesis,
the
access
to
which
from
simple
C−H
substrates
through
catalysis
of
transition
metals,
particular
earth's
abundant
ones
meets
requirements
green
and
sustainable
chemistry.
Manganese‐catalyzed
olefination
reactions
have
emerged
as
an
efficient
approach
olefins
recent
years,
complementary
traditional
olefin
synthesis.
Varieties
alkynes,
alkenes,
allenes
well
alcohols
successfully
applied
Mn‐catalyzed
with
substrates,
providing
multisubstituted
bearing
varied
functional
groups.
This
minireview
presents
great
progresses
newly
achieved
on
manganese‐catalyzed
reactions.
ChemSusChem,
Journal Year:
2018,
Volume and Issue:
12(13), P. 3083 - 3088
Published: Dec. 27, 2018
A
new
base
metal
catalyzed
sustainable
multicomponent
synthesis
of
pyrroles
from
readily
available
substrates
is
reported.
The
developed
protocol
utilizes
an
air-
and
moisture-stable
catalyst
system
enables
the
replacement
themutagenic
α-haloketones
with
abundant
1,2-diols.
Moreover,
presented
method
catalytic
in
sole
byproducts
this
transformation
are
water
hydrogen
gas.
Experimental
computational
mechanistic
studies
indicate
that
reaction
takes
place
through
a
combined
acceptorless
dehydrogenation
autotransfer
methodology.
ChemSusChem,
Journal Year:
2020,
Volume and Issue:
13(12), P. 3110 - 3114
Published: April 21, 2020
Abstract
The
reductive
amination
of
ketones
and
aldehydes
by
ammonia
is
a
highly
attractive
method
for
the
synthesis
primary
amines.
use
catalysts,
especially
reusable
based
on
earth‐abundant
metals
similarly
appealing.
Here,
iron‐catalyzed
amines
through
was
realized.
A
broad
scope
very
good
tolerance
functional
groups
were
observed.
Ketones,
including
purely
aliphatic
ones,
aryl–alkyl,
dialkyl,
heterocyclic,
as
well
could
be
converted
smoothly
into
their
corresponding
In
addition,
pharmaceuticals,
bioactive
compounds,
natural
products
demonstrated.
Many
groups,
such
hydroxy,
methoxy,
dioxol,
sulfonyl,
boronate
ester
substituents,
tolerated.
catalyst
easy
to
handle,
selective,
dissolved
in
water
employed
nitrogen
source.
key
specific
Fe
complex
an
N‐doped
SiC
material
support.
ChemSusChem,
Journal Year:
2018,
Volume and Issue:
11(22), P. 3911 - 3916
Published: Oct. 5, 2018
Abstract
A
transition‐metal‐catalyzed
borrowing
hydrogen/hydrogen
auto‐transfer
strategy
allows
the
utilization
of
feedstock
alcohols
as
an
alkylating
partner,
which
avoids
formation
stoichiometric
salt
waste
and
enables
a
direct
benign
approach
for
construction
C‐N
C−C
bonds.
In
this
study,
nickel‐catalyzed
α‐alkylation
unactivated
amides
ester
(
tert
‐butyl
acetate)
is
carried
out
by
using
primary
under
mild
conditions.
This
bond‐forming
reaction
catalyzed
new,
molecularly
defined
nickel(II)
NNN‐pincer
complex
(0.1–1
mol
%)
proceeds
through
hydrogen
auto‐transfer,
thereby
releasing
water
sole
byproduct.
addition,
N
‐alkylation
cyclic
Ni‐catalytic
conditions
demonstrated.
