Surfactants and Polymeric Micelles: Innovations in Transdermal and Topical Cosmeceutical Delivery

E3S Web of Conferences, Journal Year: 2025, Volume and Issue: 619, P. 03014 - 03014

Published: Jan. 1, 2025

Surfactants are essential to many cosmetic formulations. Cosmetic science-acceptable co-solvents or surfactants often used improve the solubility of substances that only weakly soluble in water. Surfactant-produced polymeric micelles offer a variety distinctive qualities make them very promising carrier system for cosmeceutical goods. The fundamental barrier transdermal and skin, hair, nail administration continues be cosmeceuticals’ limited biological materials, as demonstrated by around 50% cosmeceuticals. Incorporating hydrophobic actives into made is one most alluring solutions currently available address these problems. This article reviews about surfactants, their basics explaining mechanism form its applications related various site action.

Language: Английский

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Optimization of D-amino acid oxidase and epoxide hydrolase through high-performance characterization for targeted cancer therapy in sustainable biocatalysis

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142784 - 142784

Published: April 1, 2025

Language: Английский

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Design of 3D‐Printed Heterogeneous Reactor Systems To Overcome Incompatibility Hurdles when Combining Metal and Enzyme Catalysis in a One‐Pot Process

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(24)

Published: Jan. 13, 2024

Combining chemo- and biocatalysis enables the design of novel economic sustainable one-pot processes for preparation industrial chemicals, preferably proceeding in water. While a range proofs-of-concept compatibility such catalysts from these two different "worlds catalysis" have recently been demonstrated, merging noncompatible biocatalysts joint applications within one reactor remained challenge. A conceptual solution is compartmentalization catalytic moieties by heterogenization critical catalyst components, thus "shielding" them complementary catalyst, substrate or reagent. Exemplified process consisting metal-catalyzed Wacker oxidation enzymatic reduction as individual reactions steps, we demonstrate that making use 3D printing heterogeneous materials containing Cu metal component can overcome incompatibility hurdles. The application 3D-printed Cu-ceramic device allows an efficient combination with enzyme desired two-step transformation styrene into chiral alcohol product high overall conversion excellent enantioselectivity. This concept based on heterogenized represents scalable methodology opens up numerous perspectives to be used general tool also other related chemoenzymatic research challenges.

Language: Английский

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Continuous-flow chemoenzymatic enantioselective synthesis of chiral β-nitroalcohols

Molecular Catalysis, Journal Year: 2025, Volume and Issue: 580, P. 115053 - 115053

Published: April 17, 2025

Language: Английский

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Design von 3D‐gedruckten heterogenen Reaktorsystemen zur Überwindung von Inkompatibilitätshürden bei der Kombination von Metall‐ und Enzym‐Katalyse in einem Eintopf‐Prozess

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(24)

Published: Jan. 13, 2024

Abstract Die Kombination von Chemo‐ und Biokatalyse ermöglicht die Entwicklung neuartiger ökonomischer nachhaltiger Eintopfverfahren für Herstellung Industriechemikalien, welche vorzugsweise in Wasser ablaufen. Während kürzlich anhand einer Reihe Beispielen der Nachweis Kompatibilität solcher Katalysatoren aus diesen beiden unterschiedlichen “Welten Katalyse” aufgezeigt wurde, blieb Zusammenführung nicht kompatibler Biokatalysatoren gemeinsame Anwendungen einem Reaktor eine Herausforderung. Eine konzeptionelle Lösung besteht Kompartimentierung katalytischen Einheiten durch Heterogenisierung kritischer Katalysatorkomponenten, wodurch diese dem komplementären, kompatiblen Katalysator, Substrat oder Reagenz “abgeschirmt” werden. Am Beispiel eines Eintopfverfahrens, das Metall‐katalysierten Wacker‐Oxidation enzymatischen Reduktion als nicht‐kompatible Einzelreaktionsschritte besteht, zeigen wir, dass den Einsatz des 3D‐Drucks heterogenen, kritische Metallkomponente Kupfer enthaltenden Materialien solche Hürden Inkompatibilität überwinden werden können. Der 3D‐gedruckten Cu‐Keramikgerüsts Metallkatalysator‐Komponente effiziente mit Enzym gewünschte zweistufige Umwandlung Styrol chirale Alkoholprodukt hohem Gesamtumsatz exzellenter Enantioselektivität. Dieses auf 3D‐Druck heterogenisierter Metallkatalysatoren basierende Konzept zur stellt skalierbare Methodik dar eröffnet zahlreiche Perspektiven im Hinblick dessen Nutzung allgemeiner Lösungsansatz auch weitere verwandte chemoenzymatische Forschungsherausforderungen.

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Merging Organolithium Chemistry and Stereoselective Biocatalysis: Transformation of Aromatic Nitriles into Chiral Alcohols

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(14), P. 3144 - 3152

Published: June 12, 2024

Abstract The combination of RLi‐mediated organic transformations (under air and at room temperature) with a subsequent stereoselective biocatalytic reaction is for the first time presented. Most previous asymmetric chemoenzymatic routes have been limited to concomitant or sequential transition metals/organocatalysts enzymes. However, use polar organometallic reagents (RLi) in design these hybrid protocols has totally neglected, as far we are concerned. Thus, this work, organolithium chemistry biocatalysis described one‐pot fashion. approach converts series nitriles into chiral alcohols consisting two steps, where key item was finding suitable conditions adapt reactivities organolithiums alcohol dehydrogenases (ADHs) same recipient. addition occurred total chemoselectivity (no side reactions were observed) under neat temperature leading corresponding imines, which hydrolyzed using buffer, adjusting pH ADH action. Commercial made house overexpressed ADHs allowed produce excellent selectivities good overall yields. different behavior displayed reductive enzymes presence diethyl ether clearly influenced decision let solvent evaporate open‐air before developing bioreduction step. Our results demonstrate importance fine orchestration development efficient cascades without need intermediate isolation/purification steps compartmentalization synthetic systems.

Language: Английский

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BioLindlar Catalyst: Ene‐Reductase‐Promoted Selective Bioreduction of Cyanoalkynes to Give (Z)‐Cyanoalkenes

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(39)

Published: June 29, 2024

Abstract The direct synthesis of alkenes from alkynes usually requires the use transition‐metal catalysts. Unfortunately, efficient biocatalytic alternatives for this transformation have yet to be discovered. Herein, selective bioreduction electron‐deficient catalysed by ene‐reductases (EREDs) is described. Alkynes bearing ketone, aldehyde, ester, and nitrile moieties been effectively reduced with excellent conversions stereoselectivities, observing clear trends E / Z ratios depending on nature electron‐withdrawing group. In case cyanoalkynes, ( )‐alkenes were obtained as major product, reaction scope was expanded a wide variety aromatic substrates (up >99 % conversion, stereoselectivities up >99/1). Other containing or ester functionalities also proved substrates, interestingly gave corresponding )‐alkenes. Preparative biotransformations performed 0.4 mmol scale, producing desired )‐cyanoalkenes good isolated yields (63–97 %). This novel reactivity has rationalised through molecular docking predicting binding poses key molecules in ERED‐pu‐0006 active site.

Language: Английский

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BioLindlar Catalyst: Ene‐Reductase‐Promoted Selective Bioreduction of Cyanoalkynes to Give (Z)‐Cyanoalkenes

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 20, 2024

The direct synthesis of alkenes from alkynes usually requires the use transition-metal catalysts. Unfortunately, efficient biocatalytic alternatives for this transformation have yet to be discovered. Herein, selective bioreduction electron-deficient catalysed by ene-reductases (EREDs) is described. Alkynes bearing ketone, aldehyde, ester, and nitrile moieties been effectively reduced with excellent conversions stereoselectivities, observing clear trends E/Z ratios depending on nature electron-withdrawing group. In case cyanoalkynes, (Z)-alkenes were obtained as major product, reaction scope was expanded a wide variety aromatic substrates (up >99 % conversion, Z/E stereoselectivities up >99/1). Other containing or ester functionalities also proved substrates, interestingly gave corresponding (E)-alkenes. Preparative biotransformations performed 0.4 mmol scale, producing desired (Z)-cyanoalkenes good isolated yields (63-97 %). This novel reactivity has rationalised through molecular docking predicting binding poses key molecules in ERED-pu-0006 active site.

Language: Английский

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Asymmetric Chemoenzymatic One-Pot Synthesis: Process Concepts & Recent Progress in Combining Chemo- & Biocatalytic Reactions for the Formation of Chiral Molecules

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 361 - 388

Published: Jan. 1, 2024

Language: Английский

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Chemoenzymatic synthesis of N -phenyl glycine derivatives via integration of Au/TiO ₂ and enzyme as catalysts in water

Biocatalysis and Biotransformation, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 8

Published: Dec. 9, 2024

Herein, we have developed a chemoenzymatic approach for the synthesis of N-phenyl glycine derivatives involving gold-catalyzed reduction nitrophenol and engineered myoglobin-catalyzed chemoselective carbene insertion into N–H bond over O–H with alkyl diazo acetates using water as solvent. In addition, generality synthetic utility this was demonstrated by setting up scale-up reactions differently substituted nitroarenes compounds which in turn provides to 85% isolated yields.

Language: Английский

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