Annulation Producing Diverse Heterocycles Promoted by Cobalt Hydride

Published: Aug. 12, 2024

This study demonstrates the efficient synthesis of various heterocycles using metal hydrogen atom transfer (MHAT)/ radical-polar crossover (RPC) method, emphasizing its versatility under mild conditions with high functional group tolerance. By distinguishing between cyclization and annulation, we underscore complexity efficiency this approach in constructing intricate molecular architectures. Notably, incorporation an acetone solvent formation cyclic acetal dioxanes from homoallylic alcohols reveals a novel annulation mechanism. Extensive substrate scope analysis density theory calculations provide insights into reaction pathways, highlighting critical role cationic alkylcobalt(IV) intermediates collidine product selectivity. elucidates mechanisms MHAT/RPC method showcases potential as robust alternative to conventional synthetic strategies.

Language: Английский

Annulation Producing Diverse Heterocycles Promoted by Cobalt Hydride

Published: Aug. 9, 2024

This study demonstrates the efficient synthesis of various heterocycles using metal hydrogen atom transfer (MHAT)/ radical-polar crossover (RPC) method, emphasizing its versatility under mild conditions with high functional group tolerance. By distinguishing between cyclization and annulation, we underscore complexity efficiency this approach in constructing intricate molecular architectures. Notably, incorporation an acetone solvent formation cyclic acetal dioxanes from homoallylic alcohols reveals a novel annulation mechanism. Extensive substrate scope analysis density theory calculations provide insights into reaction pathways, highlighting critical role cationic alkylcobalt(IV) intermediates collidine product selectivity. elucidates mechanisms MHAT/RPC method showcases potential as robust alternative to conventional synthetic strategies.

Language: Английский