Rhodium‐Catalyzed Direct ortho‐Arylation of Anilines
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(30)
Published: April 29, 2024
Abstract
An
efficient
and
broadly
applicable
rhodium‐catalyzed
direct
ortho
‐arylation
of
anilines
with
aryl
iodides
relying
on
readily
available
aminophosphines
as
traceless
directing
groups
is
reported.
Its
scope
functional
group
compatibility
were
both
found
to
be
quite
broad
a
large
variety
(hetero)aryl
iodides,
including
complex
ones,
could
utilized.
The
‐arylated
obtained
in
high
average
yields,
without
any
competing
diarylation
full
regioselectivity,
which
constitutes
major
step
forward
compared
other
processes.
reaction
moreover
not
limited
an
bromide
triflate
successfully
used,
extended
diarylation.
Mechanistic
studies
revealed
the
key
unique
role
aminophosphine,
acting
only
substrate
but
also
ligand
for
rhodium
catalyst.
Language: Английский
Rhodium‐Catalyzed Direct ortho‐Arylation of Anilines
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(30)
Published: April 29, 2024
Abstract
An
efficient
and
broadly
applicable
rhodium‐catalyzed
direct
ortho
‐arylation
of
anilines
with
aryl
iodides
relying
on
readily
available
aminophosphines
as
traceless
directing
groups
is
reported.
Its
scope
functional
group
compatibility
were
both
found
to
be
quite
broad
a
large
variety
(hetero)aryl
iodides,
including
complex
ones,
could
utilized.
The
‐arylated
obtained
in
high
average
yields,
without
any
competing
diarylation
full
regioselectivity,
which
constitutes
major
step
forward
compared
other
processes.
reaction
moreover
not
limited
an
bromide
triflate
successfully
used,
extended
diarylation.
Mechanistic
studies
revealed
the
key
unique
role
aminophosphine,
acting
only
substrate
but
also
ligand
for
rhodium
catalyst.
Language: Английский