Recent progress in small molecule fluorescent probes for imaging and diagnosis of non-alcoholic fatty liver disease

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 513, P. 215864 - 215864

Published: May 7, 2024

Language: Английский

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Recent progress in organic carbon dot-based photosensitizers for photodynamic cancer therapy

Dyes and Pigments, Journal Year: 2024, Volume and Issue: 230, P. 112359 - 112359

Published: July 27, 2024

Language: Английский

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Selective delivery of imaging probes and therapeutics to the endoplasmic reticulum or Golgi apparatus: Current strategies and beyond

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 212, P. 115386 - 115386

Published: July 4, 2024

Language: Английский

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A Triple-Responsive and Dual-NIR Emissive Fluorescence Probe for Precise Cancer Imaging and Therapy by Activating Pyroptosis Pathway

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Revealing changes in the tumor microenvironment is crucial for understanding cancer and developing sensitive methods precise imaging diagnosis. Intracellular hydrogen peroxide (H2O2) microenvironmental factors (e.g., viscosity polarity) are closely linked to various physiological pathological processes, making them potential biomarkers cancer. However, a triple-response theranostic probe therapy has not yet been achieved due lack of effective tools. Herein, we present mitochondria-targeting near-infrared (NIR) fluorescent probe, VPH-5DF, capable simultaneously monitoring H2O2, viscosity, polarity through dual NIR channels. The specifically detects H2O2 via emission (λem = 650 nm) shows high sensitivity viscosity/polarity deep channel ≈ 750 nm). Furthermore, only monitors mitochondrial polarity, fluctuations endogenous/exogenous levels but also distinguishes cells from normal multiple parameters. Additionally, VPH-5DF can be employed monitor alterations levels, as well during drug-induced pyroptosis living cells. After treatment with chemotherapy-induced oxidative damage mitochondria activated pathway, leading robust antitumor response, evidenced xenograft models. Thus, this prodrug offers new platform vivo diagnosis anticancer chemotherapy.

Language: Английский

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pH-/Viscosity-Activatable NIR Fluorescent Probes via Acceptor Engineering of Hemicyanine Dyes for High-Contrast Bioimaging

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Real-time monitoring of the lysosomal microenvironment using small-molecule probes is critical for understanding complex interactions between organelles and diseases associated with dysfunction. Most traditional fluorescent-dye-based lysosome rely on protonation nitrogen atom in morpholine unit to visualize by inhibiting photoinduced electron transfer (PET) effect. However, these often face selectivity issues within cellular microenvironment. For instance, classic hemicyanine dyes (HD) show nonspecific fluorescence responses liver due inappropriate pKa value, leading low imaging contrast risk false positives. Herein, a series novel pH/viscosity-activatable, lysosomal-targeted near-infrared (NIR) fluorescent were developed incorporating naphthalimide dye dyes. These exhibit no at physiological pH weak under acidic conditions (key 1), substantial activation triggered abnormal viscosity pathological tissues 2). Notably, NpCy-4 demonstrated superior signal-to-background ratio (SBR) proved effective real-time situ diagnosis acute gastritis.

Language: Английский

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Protein‐Interference‐Free and Kidney‐Targeting NIR Fluorophores for Accurate in Vivo Imaging of H₂S₂ during Kidney Ferroptosis

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

High-fidelity kidney function imaging is important for assessing the nephrotoxicity of drugs and diagnosing renal diseases. However, current challenges in achieving accurate include unspecific signal enhancement due to albumin binding relatively low distribution agents kidneys. Here, first time, a side-chain engineering strategy that incorporates hydrophilic six-membered heterocycles into aza-hemicyanine generating high-performance with protein-interference-free kidney-targeting features proposed. Based on these unique dyes, albumin-insensitive H2S2 near-infrared (NIR) fluorescent probe NA-H2S2 designed, which demonstrates effective following intravenous injection specifically activated by H2S2. The designed presents highly rapid, selective sensitive response detection limit as 24.21 nm. Additionally, it successfully achieves real-time vivo NIR fluorescence during erastin/cisplatin induced ferroptosis. Moreover, also enables rapid through vitro optical urinalysis, offering significant diagnostic value Overall, this study not only practical increased accuracy but provides promising dyes further development disease-related probes.

Language: Английский

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Precise Molecular Engineering of Multi‐Suborganelle Targeted NIR Type‑I AIE Photosensitizer and Design of Cell Membrane‐Anchored Anti‐Tumor Pyroptosis Vaccine

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Abstract Photodynamically induced cell immunogenic death has emerged as an effective antitumor strategy because of its capacity to stimulate anti‐tumor immunity for eliminating primary tumors and metastases. Considering that the short‐lived reactive oxygen species (ROS) anoxic tumor microenvironment restrict efficacy conventional photodynamic therapy (PDT), a molecular framework near‐infrared (NIR) type I aggregation‐induced emission (AIE) photosensitivities with tunable sub‐organelles (including membranes, mitochondria, lipid drops, lysosomes, endoplasmic reticulum) targeting ROS in precisely regulated subcellular locations are designed. Subsequent studies have discovered under 660 nm laser irradiation, membrane‐targeted TCF‐Mem can effectively induce pyroptosis cancer cells, fully enhancing vivo preventive vaccine model. Additionally, PDT eradicate and, more importantly, inhibit growth distant through vitro actions, thereby obtaining specific immunity. This study provides novel rational design photosensitive NIR AIE offers new perspective innovative PDT‐based immune enhancement strategies.

Language: Английский

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Tuning SBDs as Endoplasmic Reticulum Self-Targeting Fluorophores and Its Application for Zn²⁺ Tracking in ER Stress

Chemical & Biomedical Imaging, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

The emerging endoplasmic recticulum (ER) crosstalk system demands a more reliable approach for ER-targeting fluorophores to explore ER-associated biochemical species and events. Providing the aromatic sulfonamides' affinity ATP-sensitive potassium channel protein localized mainly on ER membrane, sulfonamide fluorophore 4-amino-7-sulfamoylbenzoxadiazole (SBD) was modified construct self-targeting without any additional targeting group by alternating N-substituent structure numbers of its 4-amino 7-sulfamoyl groups. results revealed that ClogP value over 3.0 endowed those SBDs self-targetability effectively. This provides strategy devise an probe simply modifying as sensing moiety make CLogP despite parent SBDs, two Zn2+ probes ER-SBD-Zn1 ER-SBD-Zn2 were obtained following this idea. Moreover, tracking with disclosed first time tunicamycin concentration-dependent fluctuation behavior during stress induction.

Language: Английский

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ATP-Responsive ZIF-based NIR Fluorescent Nanosystem for Enhanced Chemo-Photodynamic Therapy of Tumors

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

An ATP-responsive fluorescence nanosystem for chemo-photodynamic therapy is reported. The can avoid premature drug leakage and enhance local delivery.

Language: Английский

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Near-Infrared-II-Activated Transition Metal(II)-Coordinated Ligand Radical Primes Robust Anticancer Immunity

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(23), P. 21329 - 21343

Published: Nov. 25, 2024

Photoactivatable metallodrugs combining tumor cell eradication and immune stimulation hold immense promise for targeted cancer therapy. However, limitations such as oxygen dependence, narrow visible light responsiveness, poor immunogenicity hinder their efficacy in deep solid tumors with hypoxic immunosuppressive microenvironments. Herein, we present a novel design strategy transition metal(II)-coordinated ligand radicals exhibiting intense near-infrared-II (NIR-II) absorption, unique endoplasmic reticulum-targeting capability, oxygen-independent photothermal performance, effectively addressing these constraints. Proof-of-concept results demonstrate the potent of our cobalt(II)-coordinated radical (

Language: Английский

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