Defluorinative Multicomponent Cascade Reaction of Trifluoromethylarenes via Palladium Photoredox Catalysis DOI Creative Commons
Zhibin Li, Lei Bao,

Kaihang Wei

et al.

Published: May 20, 2024

The incorporation of aromatic difluoromethyl motifs has proven to be a fruitful strategy for enhancing the therapeutic profiles modern pharmaceutical candidates. While defluorofunctionalization trifluoromethylarenes offers promising pathway towards diverse compounds, current methods are predominantly limited two-component reactions. Multicomponent cascade reactions (MCRs) involving transient radical still uncommon and highly sought after owing their capacity rapidly generate challenging molecular structures. In this study, we present photocatalytic manifold that combines commercially available trifluoromethylarenes, feedstock dienes various nucleophiles achieve modular defluorinative MCR. This method features mild reaction conditions broad substrate scope with excellent functional group compatibility. Furthermore, protocol enables previously unreported process formal editing resulting MCR adducts. Preliminary mechanistic studies support proposed photoinduced palladium catalytic cycle.

Language: Английский

Defluorinative Multicomponent Cascade Reaction of Trifluoromethylarenes via Palladium Photoredox Catalysis DOI Creative Commons
Zhibin Li, Lei Bao,

Kaihang Wei

et al.

Published: May 20, 2024

The incorporation of aromatic difluoromethyl motifs has proven to be a fruitful strategy for enhancing the therapeutic profiles modern pharmaceutical candidates. While defluorofunctionalization trifluoromethylarenes offers promising pathway towards diverse compounds, current methods are predominantly limited two-component reactions. Multicomponent cascade reactions (MCRs) involving transient radical still uncommon and highly sought after owing their capacity rapidly generate challenging molecular structures. In this study, we present photocatalytic manifold that combines commercially available trifluoromethylarenes, feedstock dienes various nucleophiles achieve modular defluorinative MCR. This method features mild reaction conditions broad substrate scope with excellent functional group compatibility. Furthermore, protocol enables previously unreported process formal editing resulting MCR adducts. Preliminary mechanistic studies support proposed photoinduced palladium catalytic cycle.

Language: Английский

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