Facile Construction of Quaternary Carbon Centers via Dinuclear Titanium(III)‐Catalyzed Reductive Coupling of Tertiary Chlorides and Activated Olefins DOI

Wanjiao Chen,

Huaxi Sun,

Jie Jiang

et al.

ChemCatChem, Journal Year: 2024, Volume and Issue: 16(20)

Published: June 19, 2024

Abstract The establishment of all‐carbon quaternary carbon centers represents a pivotal aspect in the synthesis numerous natural products and pharmaceutical compounds, underscoring its paramount significance synthetic organic chemistry. Herein, we present novel strategy for generation through reductive coupling tertiary halides, catalyzed by dinuclear (salen)titanium catalysts. This catalytic framework demonstrates notable reactivity towards chlorides while maintaining inertness secondary primary chlorides, thereby facilitating exceptional chemoselectivity C−C bond formation. reaction proceeds with remarkable efficiency across diverse range substrates under mild conditions.

Language: Английский

Facile Construction of Quaternary Carbon Centers via Dinuclear Titanium(III)‐Catalyzed Reductive Coupling of Tertiary Chlorides and Activated Olefins DOI

Wanjiao Chen,

Huaxi Sun,

Jie Jiang

et al.

ChemCatChem, Journal Year: 2024, Volume and Issue: 16(20)

Published: June 19, 2024

Abstract The establishment of all‐carbon quaternary carbon centers represents a pivotal aspect in the synthesis numerous natural products and pharmaceutical compounds, underscoring its paramount significance synthetic organic chemistry. Herein, we present novel strategy for generation through reductive coupling tertiary halides, catalyzed by dinuclear (salen)titanium catalysts. This catalytic framework demonstrates notable reactivity towards chlorides while maintaining inertness secondary primary chlorides, thereby facilitating exceptional chemoselectivity C−C bond formation. reaction proceeds with remarkable efficiency across diverse range substrates under mild conditions.

Language: Английский

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