Twisted‐Planar Molecular Engineering with Sonication‐Induced J‐Aggregation to Design Near‐Infrared J‐Aggregates for Enhanced Phototherapy DOI
Yubo Liu,

Yuchen Song,

Zhong‐Hong Zhu

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Abstract J‐aggregates show great promise in phototherapy, but are limited to specific molecular skeletons and poor self‐assembly controllability. Herein, we report a twisted‐planar strategy with sonication‐induced J‐aggregation develop donor–acceptor (D–A) type for phototherapy. With propeller aggregation‐induced emission (AIE) moieties as the twisted subunits thiophene planar π‐bridge, optimal π‐interaction MTSIC induces appropriate slip angle formation, redshifting absorption from 624 nm 790 nm. In contrast, shorter π‐planarity results amorphous aggregates, elongation promotes charge transfer (CT) coupled J‐aggregates. Sonication was demonstrated be effective controlling behaviors of MTSIC, which enables transformation aggregates H‐intermediates, finally stable After encapsulation lipid‐PEG, resultant J‐dots enhanced phototherapeutic effects over dots, including brightness, reactive oxygen species (ROS) generation, photothermal conversion, delivering superior cancer phototherapy performance. This work not only advances D–A design also provides promising supramolecular assembly development.

Language: Английский

Mitochondrial signaling pathways and their role in cancer drug resistance DOI
Ashwani Sharma, Tarun Virmani, Girish Kumar

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 122, P. 111329 - 111329

Published: Aug. 5, 2024

Language: Английский

Citations

8
DNA tetrahedron nanomedicine for enhanced antitumor and antimetastatic effect through the amplification of mitochondrial oxidative stress DOI
Zixuan Chen,

Zhaoyan Tian,

Yafeng Wu

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Regulated cell death mechanisms in mitochondria-targeted phototherapy DOI
Qihang Ding, Hyeonji Rha,

Changyu Yoon

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113720 - 113720

Published: April 1, 2025

Language: Английский

Citations

0
Unlocking the Potential of Disulfidptosis: Nanotechnology‐Driven Strategies for Advanced Cancer Therapy DOI
Wenyao Zhen, Tianzhi Zhao, Xiaoyuan Chen

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Tumor tissues exhibit elevated oxidative stress, with the cystine‐glutamate transporter x CT solute carrier family 7 member 11 ( CT/SLC7A11) protecting cancer cells from damage by facilitating cystine uptake for glutathione synthesis. Disulfidptosis, a newly identified form of programmed cell death (PCD), occurs in high CT/SLC7A11 expression under glucose‐deprived conditions. Distinct other PCD pathways, disulfidptosis is characterized aberrant disulfide bond formation and cellular dysfunction, ultimately resulting death. This novel mechanism offers remarkable therapeutic potential targeting inherent stress vulnerabilities rapidly growing cells. Advances nanotechnology enable development nanomaterials capable inducing reactive oxygen species (ROS) generation, disrupting bonds. In addition, they are to deliver agents directly tumors, thereby improving precision minimizing off‐target effects. Moreover, combining ROS‐induced immunogenic can remodel tumor microenvironment enhance anti‐tumor immunity. review explores mechanisms underlying disulfidptosis, its treatment, synergistic role amplifying Selective induction using represents promising strategy achieving more effective, selective, less toxic therapies.

Language: Английский

Citations

0
Twisted‐Planar Molecular Engineering with Sonication‐Induced J‐Aggregation to Design Near‐Infrared J‐Aggregates for Enhanced Phototherapy DOI
Yubo Liu,

Yuchen Song,

Zhong‐Hong Zhu

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

J-aggregates show great promise in phototherapy, but are limited to specific molecular skeletons and poor self-assembly controllability. Herein, we report a twisted-planar strategy with sonication-induced J-aggregation develop donor-acceptor (D-A) type for phototherapy. With propeller aggregation-induced emission (AIE) moieties as the twisted subunits thiophene planar π-bridge, optimal π-interaction MTSIC induces appropriate slip angle formation, redshifting absorption from 624 nm 790 nm. In contrast, shorter π-planarity results amorphous aggregates, elongation promotes charge transfer (CT) coupled J-aggregates. Sonication was demonstrated be effective controlling behaviors of MTSIC, which enables transformation aggregates H-intermediates, finally stable After encapsulation lipid-PEG, resultant J-dots enhanced phototherapeutic effects over dots, including brightness, reactive oxygen species (ROS) generation, photothermal conversion, delivering superior cancer phototherapy performance. This work not only advances D-A design also provides promising supramolecular assembly development.

Language: Английский

Citations

1
Twisted‐Planar Molecular Engineering with Sonication‐Induced J‐Aggregation to Design Near‐Infrared J‐Aggregates for Enhanced Phototherapy DOI
Yubo Liu,

Yuchen Song,

Zhong‐Hong Zhu

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Abstract J‐aggregates show great promise in phototherapy, but are limited to specific molecular skeletons and poor self‐assembly controllability. Herein, we report a twisted‐planar strategy with sonication‐induced J‐aggregation develop donor–acceptor (D–A) type for phototherapy. With propeller aggregation‐induced emission (AIE) moieties as the twisted subunits thiophene planar π‐bridge, optimal π‐interaction MTSIC induces appropriate slip angle formation, redshifting absorption from 624 nm 790 nm. In contrast, shorter π‐planarity results amorphous aggregates, elongation promotes charge transfer (CT) coupled J‐aggregates. Sonication was demonstrated be effective controlling behaviors of MTSIC, which enables transformation aggregates H‐intermediates, finally stable After encapsulation lipid‐PEG, resultant J‐dots enhanced phototherapeutic effects over dots, including brightness, reactive oxygen species (ROS) generation, photothermal conversion, delivering superior cancer phototherapy performance. This work not only advances D–A design also provides promising supramolecular assembly development.

Language: Английский

Citations

0