
Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: unknown
Published: March 20, 2025
Language: Английский
Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: unknown
Published: March 20, 2025
Language: Английский
Nano Letters, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Precise imaging of noncoding RNAs (ncRNAs) in specific organelles allows decoding their functions at subcellular level but lacks advanced tools. Here we present a DNA-based nanobiotechnology for spatially selective ncRNA (e.g., microRNA (miRNA)) mitochondria via an organelle-specific DNA assembly strategy. The target miRNA-initiated hairpins is inhibited by the block toehold-mediated strand displacement reaction can be exclusively activated mitochondria-encoded ribosomal RNA (rRNA) hybridization chain reaction, enabling spatial control over miRNA imaging. We demonstrate that conditionally controlled technology minimization nonspecific activation and thus improves precision detection. In addition, strategy adaptable to visualizing other ncRNAs such as long mitochondria, highlighting universality approach. Overall, this work provides useful tool investigating organelle-located RNA.
Language: Английский
Citations
1Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 490, P. 137847 - 137847
Published: March 5, 2025
Language: Английский
Citations
1Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: unknown
Published: March 20, 2025
Language: Английский
Citations
0