3d Transition Metals for C–H Activation

Chemical Reviews, Journal Year: 2018, Volume and Issue: 119(4), P. 2192 - 2452

Published: Nov. 27, 2018

C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with notable applications to material crop protection, drug discovery, and pharmaceutical industries, among others. Despite major advances, the vast majority of these functionalizations required precious 4d or 5d transition metal catalysts. Given cost-effective sustainable nature earth-abundant first row metals, development less toxic, inexpensive 3d catalysts gained considerable recent momentum a significantly more environmentally-benign economically-attractive alternative. Herein, we provide comprehensive overview on until summer 2018.

Language: Английский

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Mild metal-catalyzed C–H activation: examples and concepts

Chemical Society Reviews, Journal Year: 2016, Volume and Issue: 45(10), P. 2900 - 2936

Published: Jan. 1, 2016

C–H Activation reactions that proceed under mild conditions are more attractive for applications in complex molecule synthesis. Mild transformations reported since 2011 reviewed and the different concepts strategies have enabled their mildness discussed.

Language: Английский

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The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

Chemical Society Reviews, Journal Year: 2015, Volume and Issue: 45(3), P. 546 - 576

Published: Oct. 28, 2015

The advent of modern C-H functionalization chemistries has enabled medicinal chemists to consider a synthetic strategy, late stage (LSF), which utilizes the bonds drug leads as points diversification for generating new analogs. LSF approaches offer promise rapid exploration structure activity relationships (SAR), generation oxidized metabolites, blocking metabolic hot spots and preparation biological probes. This review details toolbox intermolecular with proven applicability drug-like molecules, classified by regioselectivity patterns, gives guidance on how systematically develop strategies using these patterns other considerations. In addition, number examples illustrate have been used impact actual discovery chemical biology efforts.

Language: Английский

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Cobalt-Catalyzed C–H Activation

ACS Catalysis, Journal Year: 2015, Volume and Issue: 6(2), P. 498 - 525

Published: Nov. 24, 2015

Catalytic C–H activation has emerged as a powerful tool for sustainable syntheses. In the recent years, notable success was achieved with development of cobalt-catalyzed functionalizations either in situ generated or single-component cobalt-complexes under mild reaction conditions. Herein, progress field organometallic is reviewed until November 2015.

Language: Английский

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Recent Advances in Radical C–H Activation/Radical Cross-Coupling

Chemical Reviews, Journal Year: 2017, Volume and Issue: 117(13), P. 9016 - 9085

Published: June 22, 2017

Research and industrial interest in radical C-H activation/radical cross-coupling chemistry has continuously grown over the past few decades. These reactions offer fascinating unconventional approaches toward connecting molecular fragments with high atom- step-economy that are often complementary to traditional methods. Success this area of research was made possible through development photocatalysis first-row transition metal catalysis along use peroxides as initiators. This Review provides a brief concise overview current status latest methodologies using radicals or cations key intermediates produced via activation. includes addition, cascade cyclization, radical/radical cross-coupling, coupling M-R groups, nucleophiles (Nu).

Language: Английский

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Copper-Catalyzed C–H Functionalization Reactions: Efficient Synthesis of Heterocycles

Chemical Reviews, Journal Year: 2014, Volume and Issue: 115(3), P. 1622 - 1651

Published: Dec. 22, 2014

ADVERTISEMENT RETURN TO ISSUEPREVReviewCopper-Catalyzed C–H Functionalization Reactions: Efficient Synthesis of HeterocyclesXun-Xiang Guo*†, Da-Wei Gu†, Zhengxing Wu‡, and Wanbin Zhang*‡View Author Information† Shanghai Center for Systems Biomedicine, Ministry Education Key Laboratory Jiao Tong University, 800 Dongchuan Road, 200240, China‡ School Chemistry Chemical Engineering, China*E-mail: [email protected]*E-mail: protected]Cite this: Chem. Rev. 2015, 115, 3, 1622–1651Publication Date (Web):December 22, 2014Publication History Received31 July 2014Published online22 December inissue 11 February 2015https://pubs.acs.org/doi/10.1021/cr500410yhttps://doi.org/10.1021/cr500410yreview-articleACS PublicationsCopyright © 2014 American SocietyRequest reuse permissionsArticle Views26064Altmetric-Citations849LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catalysts,Copper,Cyclization,Functionalization,Heterocyclic compounds Get e-Alerts

Language: Английский

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Electrochemical strategies for C–H functionalization and C–N bond formation

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 47(15), P. 5786 - 5865

Published: Jan. 1, 2018

This review provides an overview of the use electrochemistry as appealing platform for expediting carbon–hydrogen functionalization and carbon–nitrogen bond formation.

Language: Английский

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Electrochemical Oxidative Cross-coupling with Hydrogen Evolution: A Green and Sustainable Way for Bond Formation

Chem, Journal Year: 2017, Volume and Issue: 4(1), P. 27 - 45

Published: Dec. 14, 2017

Language: Английский

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Organocatalysis in Inert C–H Bond Functionalization

Chemical Reviews, Journal Year: 2017, Volume and Issue: 117(13), P. 9433 - 9520

Published: Feb. 13, 2017

As two coexisting and fast-growing research fields in modern synthetic chemistry, the merging of organocatalysis C–H bond functionalization is well foreseeable, joint force along this line has been demonstrated to be a powerful approach making inert more viable, predictable, selective. In review, we provide comprehensive summary over past decades. The review arranged by types bonds including alkane C–H, arene vinyl as those activated benzylic allylic alpha heteroatom such nitrogen oxygen. each section, discussion classified explicit organocatalytic mode involved.

Language: Английский

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Recent Advances in Oxidative R¹-H/R²-H Cross-Coupling with Hydrogen Evolution via Photo-/Electrochemistry

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(12), P. 6769 - 6787

Published: May 10, 2019

Photo-/electrochemical catalyzed oxidative R1-H/R2-H cross-coupling with hydrogen evolution has become an increasingly important issue for molecular synthesis. The dream of construction C-C/C-X bonds from readily available C-H/X-H release H2 can be facilely achieved without external chemical oxidants, providing a greener model bond formation. Given the great influence these reactions in organic chemistry, we give summary state art via photo/electrochemistry, and hope this review will stimulate development synthetic strategy near future.

Language: Английский

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