Nature Communications,
Journal Year:
2015,
Volume and Issue:
6(1)
Published: March 10, 2015
Cobalt-catalysed
sp(2)
C-H
bond
functionalization
has
attracted
considerable
attention
in
recent
years
because
of
the
low
cost
cobalt
complexes
and
interesting
modes
action
process.
In
comparison,
much
less
efforts
have
been
devoted
to
sp(3)
carbons.
Here
we
report
cobalt-catalysed
site-selective
dehydrogenative
cyclization
aliphatic
amides
via
a
process
on
unactivated
carbons
with
assistance
bidentate
directing
group.
This
method
provides
straightforward
synthesis
monocyclic
spiro
β-
or
γ-lactams
good
excellent
stereoselectivity
functional
group
tolerance.
addition,
new
procedure
developed
selectively
remove
group,
which
enables
free
γ-lactam
compounds.
Furthermore,
first
intermolecular
amination
is
also
realized.
ChemCatChem,
Journal Year:
2016,
Volume and Issue:
8(7), P. 1242 - 1263
Published: March 23, 2016
Abstract
C−H
functionalization
has
been
established
as
a
powerful
strategy
for
the
commercial
construction
of
organic
molecules.
This
review
encompasses
most
recent
advances
in
activation
catalyzed
by
earth‐abundant
cobalt
complexes,
involving
two
types
fundamental
reaction
paths,
that
is,
concerted
metalation–deprotonation
(CMD)
path
associated
with
non‐oxidative
and
intermolecular
single‐electron‐transfer
(SET)
path.
Transformations
high‐valent
based
on
mechanisms
used
syntheses,
including
those
C−C
C−X
(X=O
N)
bond
formation,
are
herein
presented.
Chemical Communications,
Journal Year:
2016,
Volume and Issue:
52(14), P. 2872 - 2884
Published: Jan. 1, 2016
This
feature
article
reviews
the
recent
achievements
of
rhodium-catalyzed
annulation
arenes
with
alkynes
through
weak
chelation-assisted
C–H
activation,
which
sets
a
stage
for
synthesis
diverse
appealing
polycyclic
compounds.
Angewandte Chemie International Edition,
Journal Year:
2015,
Volume and Issue:
54(18), P. 5513 - 5517
Published: March 3, 2015
Aerobic
oxidative
CH
functionalizations
of
weakly
coordinating
benzoic
acids
have
been
accomplished
with
versatile
ruthenium(II)
biscarboxylates
under
ambient
oxygen
or
air.
Mechanistic
studies
identified
the
key
factors
controlling
elementary
step
oxidation
ruthenium(0)
complex.
Journal of the American Chemical Society,
Journal Year:
2015,
Volume and Issue:
137(40), P. 12990 - 12996
Published: Sept. 21, 2015
A
new
method
of
cobalt-catalyzed
synthesis
pyrrolidinones
from
aliphatic
amides
and
terminal
alkynes
was
discovered
through
a
C–H
bond
functionalization
process
on
unactivated
sp3
carbons
with
the
silver
cocatalyst
using
bidentate
auxiliary.
For
first
time,
broad
range
easily
accessible
are
exploited
as
reaction
partner
in
C(sp3)–H
activation
to
give
important
5-ethylidene-pyrrolidin-2-ones
site-selective
fashion.
The
tolerates
wide
variety
functional
groups
including
−F,
−Cl,
−Br,
−CF3,
ether,
cyclopropane,
thiophene.
Both
pyridine
ligand
aromatic
solvent
play
role
for
promotion
reactivity.
This
cyclization
can
be
successfully
extended
afford
isoindolinones.
Attractive
features
this
catalytic
system
include
its
low
cost,
easy
operation,
convenient
access
Nature Communications,
Journal Year:
2015,
Volume and Issue:
6(1)
Published: March 10, 2015
Cobalt-catalysed
sp(2)
C-H
bond
functionalization
has
attracted
considerable
attention
in
recent
years
because
of
the
low
cost
cobalt
complexes
and
interesting
modes
action
process.
In
comparison,
much
less
efforts
have
been
devoted
to
sp(3)
carbons.
Here
we
report
cobalt-catalysed
site-selective
dehydrogenative
cyclization
aliphatic
amides
via
a
process
on
unactivated
carbons
with
assistance
bidentate
directing
group.
This
method
provides
straightforward
synthesis
monocyclic
spiro
β-
or
γ-lactams
good
excellent
stereoselectivity
functional
group
tolerance.
addition,
new
procedure
developed
selectively
remove
group,
which
enables
free
γ-lactam
compounds.
Furthermore,
first
intermolecular
amination
is
also
realized.
