Organic Letters,
Journal Year:
2019,
Volume and Issue:
21(10), P. 3769 - 3773
Published: May 7, 2019
A
visible-light-promoted
redox
neutral
γ,γ-difluoroallylation
of
cycloketone
oxime
ethers
with
trifluoromethyl
alkenes
through
C–C
and
C–F
bond
cleavage
has
been
achieved,
which
affords
various
cyano-substituted
gem-difluoroalkenes
in
generally
good
yields.
The
reaction
provides
a
facile
protocol
for
forming
gem-difluoroalkene
functionality
cyano
group
while
incorporating
them
into
one
molecule.
conversion
the
resulting
to
cyclic
monofluoroalkenes
via
second
was
also
described.
Chemical Science,
Journal Year:
2019,
Volume and Issue:
10(19), P. 5018 - 5024
Published: Jan. 1, 2019
Minisci
alkylation
is
of
prime
importance
for
its
applicability
in
functionalizing
diverse
heteroarenes,
which
are
core
structures
many
bioactive
compounds.
Organic Letters,
Journal Year:
2018,
Volume and Issue:
20(17), P. 5523 - 5527
Published: Aug. 23, 2018
A
unified
strategy
for
intermolecular
remote
C(sp3)–H
and
C–C
vinylation
of
O-acyl
oximes
with
vinyl
boronic
acids
has
been
achieved.
This
is
enabled
by
photoreductive
generation
iminyl
radicals
from
under
irradiation
visible
light.
The
translocated
carbon-centered
radicals,
which
are
generated
the
through
1,5-hydrogen
atom
transfer
or
cleavage,
can
be
vinylated
acids.
opens
up
a
new
approach
to
functionalization
via
cleavage
provides
an
efficient
versatile
solution
synthesis
γ-vinylation
ketones
nitriles.
Chemical Science,
Journal Year:
2018,
Volume and Issue:
10(1), P. 161 - 166
Published: Oct. 2, 2018
An
efficient
transition-metal
free
C–C
bond
cleavage/borylation
of
cycloketone
oxime
esters
has
been
described.
In
this
reaction,
the
B2(OH)4
reagent
not
only
served
as
boron
source
but
also
acted
an
electron
donor
through
formation
a
complex
with
DMAc-like
Lewis
base.
Green Chemistry,
Journal Year:
2020,
Volume and Issue:
22(19), P. 6334 - 6339
Published: Jan. 1, 2020
In
this
paper,
we
report
the
synthesis
of
sulfide
imidazo[1,2-a]pyridines
from
vinyl
azides,
thiophenols,
and
pyridines
via
a
radical
[3
+
2]
cycloaddition.
Organic Letters,
Journal Year:
2019,
Volume and Issue:
21(10), P. 3769 - 3773
Published: May 7, 2019
A
visible-light-promoted
redox
neutral
γ,γ-difluoroallylation
of
cycloketone
oxime
ethers
with
trifluoromethyl
alkenes
through
C–C
and
C–F
bond
cleavage
has
been
achieved,
which
affords
various
cyano-substituted
gem-difluoroalkenes
in
generally
good
yields.
The
reaction
provides
a
facile
protocol
for
forming
gem-difluoroalkene
functionality
cyano
group
while
incorporating
them
into
one
molecule.
conversion
the
resulting
to
cyclic
monofluoroalkenes
via
second
was
also
described.
