ACS Catalysis,
Journal Year:
2022,
Volume and Issue:
12(3), P. 1857 - 1878
Published: Jan. 20, 2022
A
highly
selective
and
divergent
synthesis
enables
access
to
various
molecules
has
garnered
broad
interest
from
not
only
organic
chemists
but
also
medicinal
biologists
who
work
with
chemical
libraries.
Since
the
20th
century,
such
transformations
have
been
achieved
using
transition-metal-catalyzed
reactions,
in
which
choice
of
catalyst
or
ligand
crucially
affects
selectivity.
Over
past
several
decades,
photocatalysts
attracted
a
considerable
amount
attention
because
they
provide
additional
ways
control
reaction
intermediates
product
selectivity
via
electron
energy
transfer.
From
this
perspective,
we
highlight
recent
development
switchable
syntheses
photocatalysts,
are
difficult
achieve
classical
catalytic
transformations.
Chemical Reviews,
Journal Year:
2020,
Volume and Issue:
121(1), P. 506 - 561
Published: May 29, 2020
Thermal
C–C
bond
cleavage
reactions
allow
the
construction
of
structurally
diverse
molecular
skeletons
via
predictable
and
efficient
reorganizations.
Visible
light
photoredox-catalyzed
radical-mediated
have
recently
emerged
as
a
powerful
alternative
method
for
overcoming
thermodynamic
kinetic
barrier
in
scaffolds.
In
recent
years,
plethora
elegant
useful
been
invented,
products
are
sometimes
otherwise
inaccessible
by
classic
thermal
reactions.
Considering
great
influence
synthetic
potential
these
reactions,
we
provide
summary
state
art
visible
light-driven
cleavage/functionalization
strategies
with
specific
emphasis
on
working
models.
We
hoped
that
this
review
will
be
medicinal
organic
chemists
inspire
further
reaction
development
interesting
area.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(2), P. 1925 - 2016
Published: Sept. 29, 2021
The
fields
of
C–H
functionalization
and
photoredox
catalysis
have
garnered
enormous
interest
utility
in
the
past
several
decades.
Many
different
scientific
disciplines
relied
on
strategies
including
natural
product
synthesis,
drug
discovery,
radiolabeling,
bioconjugation,
materials,
fine
chemical
synthesis.
In
this
Review,
we
highlight
use
reactions.
We
separate
review
into
inorganic/organometallic
catalysts
organic-based
catalytic
systems.
Further
subdivision
by
reaction
class─either
sp2
or
sp3
functionalization─lends
perspective
tactical
for
these
methods
synthetic
applications.
Synthesis,
Journal Year:
2018,
Volume and Issue:
50(08), P. 1569 - 1586
Published: Feb. 12, 2018
The
selective
functionalization
of
remote
C–H
bonds
via
intramolecular
hydrogen
atom
transfer
(HAT)
is
transformative
for
organic
synthesis.
This
radical-mediated
strategy
provides
access
to
novel
reactivity
that
complementary
closed-shell
pathways.
As
modern
methods
mild
generation
radicals
are
continually
developed,
inherent
selectivity
paradigms
HAT
mechanisms
offer
unparalleled
opportunities
developing
new
strategies
functionalization.
review
outlines
the
history,
recent
advances,
and
mechanistic
underpinnings
as
a
guide
addressing
ongoing
challenges
in
this
arena.
1
Introduction
2
Nitrogen-Centered
Radicals
2.1
sp3
N-Radical
Initiation
2.2
sp2
3
Oxygen-Centered
3.1
Carbonyl
Diradical
3.2
Alkoxy
Radical
3.3
Non-alkoxy
4
Carbon-Centered
4.1
C-Radical
4.2
5
Conclusion
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(6), P. 5682 - 5841
Published: Oct. 18, 2021
Transition-metal-catalyzed
C–H
activation
has
developed
a
contemporary
approach
to
the
omnipresent
area
of
retrosynthetic
disconnection.
Scientific
researchers
have
been
tempted
take
help
this
methodology
plan
their
synthetic
discourses.
This
paradigm
shift
helped
in
development
industrial
units
as
well,
making
synthesis
natural
products
and
pharmaceutical
drugs
step-economical.
In
vast
zone
bond
activation,
functionalization
proximal
bonds
gained
utmost
popularity.
Unlike
bonds,
distal
is
more
strenuous
requires
distinctly
specialized
techniques.
review,
we
compiled
various
methods
adopted
functionalize
mechanistic
insights
within
each
these
procedures,
scope
methodology.
With
give
complete
overview
expeditious
progress
made
field
organic
chemistry
while
also
highlighting
its
pitfalls,
thus
leaving
open
for
further
modifications.
Chemical Reviews,
Journal Year:
2020,
Volume and Issue:
120(17), P. 9790 - 9833
Published: Aug. 6, 2020
Alkyl
radicals
are
key
intermediates
in
organic
synthesis.
Their
classic
generation
from
alkyl
halides
has
a
severe
drawback
due
to
the
employment
of
toxic
tin
hydrides
point
that
"flight
tyranny
tin"
radical
processes
was
considered
for
long
time
an
unavoidable
issue.
This
review
summarizes
main
alternative
approaches
unstabilized
radicals,
using
photons
as
traceless
promoters.
The
recent
development
photochemical
and
photocatalyzed
enabled
discovery
plethora
new
precursors,
opening
world
chemistry
broader
community,
thus
allowing
era
photon
democracy.
Angewandte Chemie International Edition,
Journal Year:
2017,
Volume and Issue:
57(3), P. 744 - 748
Published: Nov. 8, 2017
Abstract
A
photoinduced
cascade
strategy
leading
to
a
variety
of
differentially
functionalised
nitriles
and
ketones
has
been
developed.
These
reactions
rely
on
the
oxidative
generation
iminyl
radicals
from
simple
oximes.
Radical
transposition
by
C(sp
3
)−(sp
)
)−H
bond
cleavage
gives
access
distal
carbon
that
undergo
S
H
2
functionalisations.
mild,
visible‐light‐mediated
procedures
can
be
used
for
remote
fluorination,
chlorination,
azidation,
were
applied
modification
bioactive
structurally
complex
molecules.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
50(2), P. 766 - 897
Published: Dec. 22, 2020
Recent
developments
and
future
prospects
of
visible-light
photocatalysis
in
the
late-stage
functionalization
pharmaceuticals
natural
bioactive
compounds.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(2), P. 2907 - 2980
Published: Sept. 24, 2021
In
the
pursuit
of
new
pharmaceuticals
and
agrochemicals,
chemists
in
life
science
industry
require
access
to
mild
robust
synthetic
methodologies
systematically
modify
chemical
structures,
explore
novel
space,
enable
efficient
synthesis.
this
context,
photocatalysis
has
emerged
as
a
powerful
technology
for
synthesis
complex
often
highly
functionalized
molecules.
This
Review
aims
summarize
published
contributions
field
from
industry,
including
research
industrial-academic
partnerships.
An
overview
developed
strategic
applications
synthesis,
peptide
functionalization,
isotope
labeling,
both
DNA-encoded
traditional
library
is
provided,
along
with
summary
state-of-the-art
photoreactor
effective
upscaling
photocatalytic
reactions.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(13), P. 7359 - 7377
Published: Jan. 1, 2021
The
generation
of
heteroatom-centred
radicals
followed
by
intramolecular
1,5-HAT
and
functionalisation
the
translocated
carbon-centred
radical
is
an
efficient
way
to
functionalize
chemo-
regio-selectively
remote
unactivated
C(sp3)–H
bond.
