Synlett,
Journal Year:
2021,
Volume and Issue:
32(13), P. 1309 - 1315
Published: March 5, 2021
Abstract
Magnesium
(Mg)
is
a
cheap,
non-toxic,
and
recyclable
alkaline
earth
metal
that
constitutes
about
2%
weight
in
the
Earth’s
crust.
The
use
of
magnesium
catalysts
to
forge
chiral
moieties
molecules
highly
attractive.
Based
on
our
work
recent
years,
we
describe
current
progress
development
situ
generated
their
application
asymmetric
synthesis.
In
this
perspective,
critically
concise
classification
catalytic
modes,
with
relevant
examples,
presented,
representative
mechanisms
each
category
are
discussed.
Building
established
diverse
strategies,
one
can
foresee
more
innovative
structurally
creative
will
be
developed
overcome
formidable
challenges
enantioselective
reactions.
1
Introduction
2
Catalysts
Generated
Situ
from
Chiral
Ligands
Containing
Dual
Reactive
Hydrogens
3
Monoanionic
4
Bimetallic
Polymetallic
Assembled
5
Summary
Outlook
Advanced Synthesis & Catalysis,
Journal Year:
2019,
Volume and Issue:
361(16), P. 3744 - 3750
Published: June 7, 2019
Abstract
Construction
of
enantioenriched
2
H
‐
and
3
‐pyrroles
are
achieved
in
current
work
by
using
readily
available
α‐isocyanoacetates
alkynyl
ketones
as
precursors.
To
realize
the
asymmetric
synthesis
‐pyrroles,
a
proper
situ
generated
magnesium
catalytic
method
was
developed.
On
other
hand,
discovery
an
aluminium
mediated
chirality
maintaining
1,5
‐ester
shift
reaction
promoted
successful
‐pyrroles.
magnified
image
Green Chemistry,
Journal Year:
2020,
Volume and Issue:
22(4), P. 1119 - 1124
Published: Jan. 1, 2020
A
catalytic
and
site-selective
approach
has
been
demonstrated
for
dual
functionalization
of
arenes
via
cross-coupling
reactions
p-quinols
with
amines
isocyanides/phosphites.
ChemistryOpen,
Journal Year:
2019,
Volume and Issue:
8(5), P. 621 - 626
Published: May 1, 2019
Abstract
The
α‐metallated
ylides
[Ph
3
P−C−Z]
−
M
+
(with
Z=SO
2
Tol
or
CN
and
M=Na
K)
were
used
as
versatile
nucleophiles
for
the
facile
access
to
ylide‐substituted
compounds.
Halogenations,
alkylations,
carbonylations
functionalization
reactions
with
main
group
element
halides
easily
accomplished
by
simple
trapping
appropriate
electrophiles.
X‐ray
crystallographic
studies
of
all
compounds
–
including
first
structures
α‐fluorinated
P‐ylides
showed
remarkable
differences
in
ylide
backbone
depending
on
substituents.
In
fluorinated
compounds,
a
change
from
fully
planar
pyramidalized
ylidic
carbon
centre
was
observed
despite
strongly
anion‐stabilizing
ability
yldiide
substituent.
π‐Donation
substituent
also
resulted
geometric
restrictions
steric
electronic
properties
introduced
Synlett,
Journal Year:
2021,
Volume and Issue:
32(13), P. 1309 - 1315
Published: March 5, 2021
Abstract
Magnesium
(Mg)
is
a
cheap,
non-toxic,
and
recyclable
alkaline
earth
metal
that
constitutes
about
2%
weight
in
the
Earth’s
crust.
The
use
of
magnesium
catalysts
to
forge
chiral
moieties
molecules
highly
attractive.
Based
on
our
work
recent
years,
we
describe
current
progress
development
situ
generated
their
application
asymmetric
synthesis.
In
this
perspective,
critically
concise
classification
catalytic
modes,
with
relevant
examples,
presented,
representative
mechanisms
each
category
are
discussed.
Building
established
diverse
strategies,
one
can
foresee
more
innovative
structurally
creative
will
be
developed
overcome
formidable
challenges
enantioselective
reactions.
1
Introduction
2
Catalysts
Generated
Situ
from
Chiral
Ligands
Containing
Dual
Reactive
Hydrogens
3
Monoanionic
4
Bimetallic
Polymetallic
Assembled
5
Summary
Outlook
