Angewandte Chemie,
Journal Year:
2020,
Volume and Issue:
133(24), P. 13306 - 13332
Published: July 16, 2020
Abstract
The
creation
of
new
chiral
ligands
capable
providing
high
stereocontrol
in
metal‐catalyzed
reactions
is
crucial
modern
organic
synthesis.
production
bioactive
molecules
as
single
enantiomers
increasingly
required,
and
asymmetric
catalysis
with
metal
complexes
constitutes
one
the
most
efficient
synthetic
strategies
to
access
optically
active
compounds.
Herein
we
offer
a
historical
overview
on
development
derivatives
ubiquitous
cyclopentadienyl
ligand
(Cp
X
),
detail
their
successful
application
broad
range
transformations.
Those
include
functionalization
challenging
C−H
bonds
beyond,
giving
an
extensive
catalogue
valuable
molecules.
A
critical
comparison
existing
families,
design,
synthesis,
complexation
different
metals
also
provided.
In
addition,
future
research
directions
are
discussed
further
enhance
performance
Cp
enantioselective
catalysis.
ACS Catalysis,
Journal Year:
2022,
Volume and Issue:
12(5), P. 3083 - 3093
Published: Feb. 21, 2022
Efficient
synthesis
of
planar
chiral
ferrocene-fused
heterocyclic
molecules
is
challenging
in
asymmetric
synthesis.
Herein,
we
report
an
enantioselective
C–H
activation/annulation
ferrocenecarboxamides
with
internal
alkynes
promoted
by
CpRh(III)
catalysis.
Trisubstituted
Cp-derived
Rh
complexes
are
found
to
be
enabling
catalysts,
which
lead
a
broad
substrate
scope
good
functional
group
compatibility.
Planar
pyridone
products
obtained
high
yields
(up
90%)
excellent
enantioselectivity
99%
ee).
Combined
experimental
and
computational
studies
support
the
proposed
reaction
mechanism.
Organic Letters,
Journal Year:
2020,
Volume and Issue:
22(21), P. 8256 - 8260
Published: Oct. 16, 2020
The
enantioselective
C–H
alkylation
of
8-ethylquinolines
with
enones
or
acrolein
using
a
RhIII
catalyst
and
chiral
carboxylic
acid
is
described.
Under
mild
reaction
conditions,
binaphthyl-based
enables
the
cleavage
8-ethylquinoline
C(sp3)–H
bond.
obtained
results
demonstrate
utility
combination
high-valent
group
9
metal
for
activation
subsequent
C–C
bond
formation.
