Recent Progress in Electrochemiluminescence Sensing and Imaging

Analytical Chemistry, Journal Year: 2019, Volume and Issue: 92(1), P. 431 - 454

Published: Nov. 4, 2019

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTRecent Progress in Electrochemiluminescence Sensing and ImagingCheng MaCheng MaState Key Laboratory of Analytical Chemistry for Life Science, School Chemical Engineering, Nanjing University, 210023, P. R. ChinaMore by Cheng MaView Biographyhttp://orcid.org/0000-0001-5729-8483, Yue CaoYue CaoState CaoView Biographyhttp://orcid.org/0000-0002-8934-7195, Xiaodan GouXiaodan GouState GouView Biography, Jun-Jie Zhu*Jun-Jie ZhuState China*E-mail: [email protected]More ZhuView Biographyhttp://orcid.org/0000-0002-8201-1285Cite this: Anal. Chem. 2020, 92, 1, 431–454Publication Date (Web):November 3, 2019Publication History Published online4 November 2019Published inissue 7 January 2020https://pubs.acs.org/doi/10.1021/acs.analchem.9b04947https://doi.org/10.1021/acs.analchem.9b04947review-articleACS PublicationsCopyright © 2019 American SocietyRequest reuse permissionsArticle Views11665Altmetric-Citations354LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Electrodes,Genetics,Metal organic frameworks,Quantum dots,Sensors Get e-Alerts

Language: Английский

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Dual Enhancement of Gold Nanocluster Electrochemiluminescence: Electrocatalytic Excitation and Aggregation‐Induced Emission

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 59(25), P. 9982 - 9985

Published: Nov. 6, 2019

Abstract Ligand‐protected gold nanoclusters (AuNCs) have emerged as a new class of electrochemiluminescence (ECL) luminophores for their interesting catalytic and emission properties, although quantum yield ( Φ ECL ) in aqueous medium is low with poor mechanistic understanding the process. Now it shown that drying AuNCs on electrodes enabled both enhanced electrochemical excitation by an electrocatalytic effect, aggregation‐induced (AIECL) 6‐aza‐2‐thiothymine (ATT) protected triethylamine (TEA) coreactant. The dried ATT‐AuNCs/TEA system resulted highly stable visual 78 %, similar enhancement was also achieved methionine‐capped AuNCs. dual‐enhancement mechanism has solved challenging problem AuNC probes, can guide further rational design emitters.

Language: Английский

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Dual Intramolecular Electron Transfer for In Situ Coreactant‐Embedded Electrochemiluminescence Microimaging of Membrane Protein

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(1), P. 197 - 201

Published: Sept. 21, 2020

Abstract The demand for transporting coreactant to emitter and short lifetime of the radicals in electrochemiluminescence (ECL) emission inhibit greatly its application cytosensing microscopic imaging. Herein we designed a dual intramolecular electron transfer strategy tertiary amine conjugated polymer dots (TEA‐Pdots) develop coreactant‐embedded ECL mechanism microimaging system. TEA‐Pdots could produce at +1.2 V without need test solution. superstructure led unprecedented strength, which was 132 45 times stronger than those from mixture Pdots with TEA equivalent 62.5 higher amounts, respectively. efficiency even that typical [Ru(bpy) 3 ] 2+ Therefore, this system be used situ membrane protein on single living cells additional permeable treatment coreactant. feasibility validity were demonstrated by evaluating specific expression cell surface. This work opens new avenues applications analysis dynamic study biological events.

Language: Английский

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Amplification-free CRISPR/Cas detection technology: challenges, strategies, and perspectives

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(1), P. 361 - 382

Published: Dec. 19, 2022

This review summarizes the recent advances and main strategies to improve sensitivity of amplification-free CRISPR/Cas-based detection techniques.

Language: Английский

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Ultrafast Condensation of Carbon Nitride on Electrodes with Exceptional Boosted Photocurrent and Electrochemiluminescence

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 59(3), P. 1139 - 1143

Published: Oct. 28, 2019

Semiconducting polymeric carbon nitride (CN) has drawn wide attention ranging from photocatalysis to more recent biosensing owing unique defect-tolerated optoelectronic properties and being metal-free, cheap, highly stable. However, at the core of electrical-optical interconversion, preparation CN photoelectrode is still challenging. Now, growth on electrodes achieved simply by microwave-assisted condensation in seconds. The ultrafast heating not only addressed thermodynamic contradiction precursor volatilization during polymerization but also led strongly adhesive layer with gradient carbon-rich texture, greatly accelerating electron-hole separation mobility. Consequently, exhibited a remarkable photocurrent record cathodic efficiency electrochemiluminescence up 7 times that benchmark Ru(bpy)3 Cl2 aqueous solution.

Language: Английский

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A general design approach toward covalent organic frameworks for highly efficient electrochemiluminescence

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Aug. 5, 2021

Abstract Electrochemiluminescence (ECL) plays a key role in analysis and sensing because of its high sensitivity low background. Its wide applications are however limited by lack highly tunable ECL luminophores. Here we develop scalable method to design emitters covalent organic frameworks (COFs) aqueous medium simultaneously restricting the donor acceptor COFs’ tight electron configurations constructing high-speed charge transport networks through olefin linkages. This allows efficient intramolecular transfer for strong ECL, no exogenous poisonous co-reactants needed. Olefin-linked donor-acceptor conjugated COFs, systematically synthesized combining non-ECL active monomers with C 2v or 3v symmetry, exhibit signals, which can be boosted increasing chain length conjugation monomers. The present concept demonstrates that COF-based luminophores precisely designed, providing promising direction toward phosphors.

Language: Английский

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Engineering luminescent metal nanoclusters for sensing applications

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 451, P. 214268 - 214268

Published: Oct. 21, 2021

Language: Английский

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Intrareticular charge transfer regulated electrochemiluminescence of donor–acceptor covalent organic frameworks

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Nov. 23, 2021

The control of charge transfer between radical anions and cations is a promising way for decoding the emission mechanism in electrochemiluminescence (ECL) systems. Herein, type donor-acceptor (D-A) covalent organic framework (COF) with triphenylamine triazine units designed as highly efficient ECL emitter tunable intrareticular (IRCT). D-A COF demonstrates 123 folds enhancement intensity compared its benzene-based small contrast. Further, COF's crystallinity- protonation-modulated behaviors confirm dependence on donor acceptor units, which rationalized by density functional theory. Significantly, dual-peaked patterns COFs are achieved through an IRCT mediated competitive oxidation mechanism: coreactant-mediated at lower potential direct higher potential. This work provides new fundamental approach to improve efficiency designing next-generation devices.

Language: Английский

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Cas12a-based electrochemiluminescence biosensor for target amplification-free DNA detection

Biosensors and Bioelectronics, Journal Year: 2021, Volume and Issue: 176, P. 112954 - 112954

Published: Jan. 1, 2021

Language: Английский

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Electrochemiluminescence Distance and Reactivity of Coreactants Determine the Sensitivity of Bead‐Based Immunoassays

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(16)

Published: Feb. 22, 2023

Abstract Herein we report the study of electrochemiluminescence (ECL) generation by tris(2,2′‐bipyridyl)ruthenium (Ru(bpy) 3 2+ ) and five tertiary amine coreactants. The ECL distance lifetime coreactant radical cations were measured self‐interference spectroscopy. And reactivity coreactants was quantitatively evaluated in terms integrated intensity. By statistical analysis images single Ru(bpy) ‐labeled microbeads, propose that codetermine emission intensity thus sensitivity immunoassay. 2,2‐bis(hydroxymethyl)‐2,2′,2′′‐nitrilotriethanol (BIS‐TRIS) can well balance distance‐reactivity trade‐off enhance 236 % compared with tri‐ n ‐propylamine (TPrA) bead‐based immunoassay carcinoembryonic antigen. brings an insightful understanding a way maximizing analytical from aspect coreactant.

Language: Английский

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