Chemical Communications,
Journal Year:
2021,
Volume and Issue:
57(81), P. 10576 - 10579
Published: Jan. 1, 2021
A
palladium-catalysed
construction
of
spiroindolines
through
dearomative
spirocyclization
3-(2-isocyanoethyl)indoles
has
been
developed.
2'-Aryl-,
vinyl-,
and
alkyl-substituted
could
be
accessed
under
mild
conditions
with
excellent
functional
group
tolerance.
C1-tethered
oxindole-
indole-spiroindoline
bisheterocycles
were
generated
in
high
yields
via
alkene/allene
insertion
an
imidoylative
cascade.
Additionally,
a
tandem
dearomatization
two
different
indoles
was
realized
N-(2-bromobenzoyl)indoles
as
the
electrophilic
coupling
partner
3-(2-isocyanoethyl)indoles,
affording
polyindoline
-
spiroindoline
bisheterocyclic
scaffolds
conveniently.
Under
catalysis
Pd(OAc)2
spinol-derived
phosphoramidite
ligand,
chiral
successfully
up
to
95%
yield
85%
ee.
Organic Letters,
Journal Year:
2020,
Volume and Issue:
22(21), P. 8326 - 8331
Published: Oct. 12, 2020
Herein,
a
selective
tandem
C–C
bond-forming
reaction
with
CO2
was
developed
to
realize
the
bridging
of
enaminones
and
synthesis
1,4-dihydropyridines,
respectively.
n-Butylamine
significantly
promoted
this
deoxymethylenation
procedure
catalyzed
by
1,5,7-triazabicyclo[4.4.0]dec-5-ene
(TBD)
ZnCl2.
The
mechanism
involving
formation
bis(silyl)acetal,
nucleophilic
addition,
amine
elimination
also
interpreted
clarify
two
molecules
generation
dihydropyridine
derivatives.
Organic Letters,
Journal Year:
2020,
Volume and Issue:
22(19), P. 7640 - 7644
Published: Sept. 15, 2020
A
silver-catalyzed
cascade
cyclization
reaction
of
isocyanides
with
sulfoxonium
ylides
has
been
developed
for
the
first
time.
This
provides
a
new
and
efficient
method
construction
highly
functionalized
3-aminofurans
4-aminoquinolines
from
readily
available
starting
materials
in
single
step.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
Domino
cascade
reactions,
which
can
construct
multiple
bonds
in
one
pot,
are
efficient
methods
to
synthesize
N-heterocycles
and
other
useful
skeletons.
Herein,
we
report
an
expedient
synthesis
of
polysubstituted
benzo[b][1,5]naphthyridine
via
Mn(III)-mediated
C–C
bond
cleavage
cyclopropanols.
These
reactions
were
initiated
by
addition
β-carbonyl
radicals,
generated
from
cyclopropyl
alcohols
the
presence
Mn(III),
2-(2-isocyanophenyl)acetonitriles
give
quinolin-3-amines,
went
through
intramolecular
cyclizations
dehydrogenation
final
products.
European Journal of Organic Chemistry,
Journal Year:
2020,
Volume and Issue:
2020(32), P. 5192 - 5200
Published: July 2, 2020
Fluoroalkyl(hetero)arylation
of
allylic
alcohols
with
perfluoroalkyl
iodide
or
difluoroacetic
acid
as
fluoroalkyl
source
was
developed
herein,
delivering
functionalized
ketones
containing
an
α‐quaternary
center.
Formation
the
radical
followed
by
its
intermolecular
addition
to
alkenes
and
migration
a
(hetero)aryl
group
concomitant
generation
ketone
finish
domino
sequence.
Mechanistic
studies
indicated
that
aryl
proceeded
through
neophyl
rearrangement
in
pathway.
Moreover,
preliminary
antifungal
evaluation
against
Magnaporthe
grisea
is
also
described
for
first
time.
