Organic Process Research & Development,
Journal Year:
2020,
Volume and Issue:
24(6), P. 909 - 915
Published: May 14, 2020
Nonprecious
metal
catalysis
is
a
highly
active
area
of
research
for
both
industrial
and
academic
laboratories.
New
methods
that
efficiently
generate
useful
functionality
in
cost-effective,
high
yielding,
environmentally
friendly
ways
naturally
garner
attention
from
process
chemists
many
different
industries.
This
series
highlights
summarizes
literature
on
the
general
topic
nonprecious
over
four-month
timeframes
will
focus
major
trends
field
are
interest
pharmaceutical
industry.
The
first
installment
selected
transformations
using
copper,
nickel,
iron
catalysts.
Journal of the American Chemical Society,
Journal Year:
2021,
Volume and Issue:
143(14), P. 5330 - 5335
Published: March 30, 2021
The
catalytic
enantioselective
synthesis
of
α-chiral
olefins
represents
a
valuable
strategy
for
rapid
generation
structural
diversity
in
divergent
syntheses
complex
targets.
Herein,
we
report
protocol
the
dual
CuH-
and
Pd-catalyzed
asymmetric
Markovnikov
hydroalkenylation
vinyl
arenes
anti-Markovnikov
unactivated
olefins,
which
readily
available
enol
triflates
can
be
utilized
as
alkenyl
coupling
partners.
This
method
allowed
diverse
including
tri-
tetrasubstituted
olefin
products,
are
challenging
to
prepare
by
existing
approaches.
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: Oct. 7, 2021
Hydroalkylation,
the
direct
addition
of
a
C(sp3)-H
bond
across
an
olefin,
is
desirable
strategy
to
produce
valuable,
complex
structural
motifs
in
functional
materials,
pharmaceuticals,
and
natural
products.
Herein,
we
report
reliable
method
for
accessing
α-branched
amines
via
nickel-catalyzed
hydroalkylation
reactions.
Specifically,
by
using
bis(cyclooctadiene)nickel
(Ni(cod)2)
together
with
phosphine
ligand,
achieved
formal
insertion
reaction
between
olefins
N-sulfonyl
without
need
external
hydride
source.
The
amine
not
only
provides
alkyl
motif
but
also
delivers
olefin
means
nickel-engaged
β-hydride
elimination/reductive
elimination
process.
This
platform
constructing
chiral
P-chiral
demonstrating
its
potential
utility
organic
synthesis.
Notably,
sulfonamidyl
boronate
formed
situ
under
basic
conditions
promotes
ring-opening
azanickellacycle
intermediate,
leading
significant
improvement
catalytic
efficiency.
Chinese Journal of Chemistry,
Journal Year:
2022,
Volume and Issue:
41(3), P. 294 - 300
Published: Oct. 17, 2022
Comprehensive
Summary
NiH‐catalyzed
multicomponent
reductive
hydrofunctionalization
of
alkenes
is
an
attractive
but
poorly
explored
approach
to
rapidly
increasing
molecular
complexity.
In
this
process,
the
selective
generation
desired
product
can
be
challenging.
Herein,
we
report
that
a
highly
chemo‐,
regio‐
and
enantioselective
hydrocarbonylation
has
been
achieved
using
chloroformate
ester
as
source
CO.
A
wide
range
structurally
diverse
α‐hydroxy
ketones,
privileged
structural
elements
in
bioactive
molecules
useful
building
blocks,
were
obtained
from
such
reactions
with
high
enantiomeric
purity.
Organic Chemistry Frontiers,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Enantioselective
construction
of
cycloalkyl
amines
with
two
adjacent
chiral
centers
via
transannular
directed,
NiH-catalysed
cycloalkene
desymmetric
hydroalkylation.
Organic Process Research & Development,
Journal Year:
2020,
Volume and Issue:
24(6), P. 909 - 915
Published: May 14, 2020
Nonprecious
metal
catalysis
is
a
highly
active
area
of
research
for
both
industrial
and
academic
laboratories.
New
methods
that
efficiently
generate
useful
functionality
in
cost-effective,
high
yielding,
environmentally
friendly
ways
naturally
garner
attention
from
process
chemists
many
different
industries.
This
series
highlights
summarizes
literature
on
the
general
topic
nonprecious
over
four-month
timeframes
will
focus
major
trends
field
are
interest
pharmaceutical
industry.
The
first
installment
selected
transformations
using
copper,
nickel,
iron
catalysts.
