Photocatalytic Regioselective C–H Bond Functionalizations in Arenes DOI Creative Commons
Jun Hu, Suman Pradhan, Satyadeep Waiba

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

The direct functionalization of C–H bonds has revolutionized the field synthetic organic chemistry by enabling efficient and atom-economical modification arenes avoiding prefunctionalization.

Language: Английский

Direct access to carbamates via acylation of arylamines with dialkyl azodicarboxylates under metal-free conditions DOI
Liangxin Fan,

Mengyang He,

Xin‐Yuan Liu

et al.

Organic & Biomolecular Chemistry, Journal Year: 2023, Volume and Issue: 21(45), P. 9037 - 9048

Published: Jan. 1, 2023

A novel C-N coupling of various arylamines with dialkyl azodicarboxylates under metal-free conditions for the rapid assembly carbamates has been achieved. This established protocol features mild reaction conditions, simple operation, broad substrate scope, moderate to excellent yields and good tolerance functional groups. Moreover, potential synthetic utility products was exemplified by a series intriguing chemical operations.

Language: Английский

Citations

1
One‐Pot Multicomponent Selective Synthesis of 5‐Trifluoromethyl Pyrimidine Derivatives DOI

Dingyuan Lou,

Yuxin Ding,

Zhening Jin

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(12), P. 2715 - 2720

Published: May 9, 2024

Abstract A one‐pot multi‐component reaction strategy for the selective synthesis of 5‐trifluoromethyl pyrimidine derivatives has been established. This method avoids inherent selectivity challenges in direct trifluoromethylation. The demonstrates tolerance to various functional groups, yielding with up 80% yields. Moreover, practicality this underscored through scale‐up reactions.

Language: Английский

Citations

0
A Ligand-assisted Manganese-enabled Direct C-H Difluoromethylation of Arenes DOI

Kehan Zhou,

Shuang Xia,

Yuheng Xiao

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(17), P. 4874 - 4881

Published: Jan. 1, 2024

The incorporation of a difluoromethyl group within an aromatic ring is highly desirable.

Language: Английский

Citations

0
Polar-Effect-Directed Control in Site-Selectivity of Radical Substitution Enables C–H Perfluoroalkylation of Coumarins DOI
Shashank Singh, Ravi P. Singh

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

A novel Ru-catalyzed protocol for C-7 selective C-H trifluoromethylation of coumarins in the presence light is presented. This reaction undergoes a radical type nucleophilic substitution instead electrophilic owing to benzocore activation as result lowering lowest unoccupied molecular orbital (LUMO).

Language: Английский

Citations

0
Photocatalytic Regioselective C–H Bond Functionalizations in Arenes DOI Creative Commons
Jun Hu, Suman Pradhan, Satyadeep Waiba

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

The direct functionalization of C–H bonds has revolutionized the field synthetic organic chemistry by enabling efficient and atom-economical modification arenes avoiding prefunctionalization.

Language: Английский

Citations

0