Recent Advances and Clinical Potential of Near Infrared Photothermal Conversion Materials for Photothermal Hepatocellular Carcinoma Therapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(29)

Published: June 9, 2023

Abstract Growing concern about photothermal tumor therapy (PTT) as a promising alternative to conventional liver cancer treatment, which is treatment strategy that utilizes near‐infrared (NIR) light‐induced agents (PTAs) yield effects localize thermal damage for tumors. Herein, given the gap between experimental research and clinical application, this review seeks timely summarize highlight recent progress of PTAs used in vivo vitro last five‐year. The implications various on multifunctional conversion capability, structure‐performance correlations PTT, together with evaluation their potential application are systematically dissected further dig out what buried mechanism is. Besides, higher requirements put forward discrepancies crucial issues faced by different PTT related medical technical obstacles being conquered, lays solid theoretical foundation field oncology whole, especially cancer. Finally, it expected can present valuable guidance design efficient, photostability, biosafety‐aware anticancer while stepping into fast traffic lane from bench bedside foreseeable future.

Language: Английский

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Adding Flying Wings: Butterfly-Shaped NIR-II AIEgens with Multiple Molecular Rotors for Photothermal Combating of Bacterial Biofilms

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(47), P. 25705 - 25715

Published: Nov. 16, 2023

The ever-increasing threats of multidrug-resistant bacteria and their biofilm-associated infections have bred a desperate demand for alternative remedies to combat them. Near-infrared (NIR)-absorbing photothermal agent (PTAs)-mediated therapy (PTT) is particularly attractive biofilm ablation thanks its superiorities noninvasive intervention, satisfactory antibacterial efficiency, less likelihood develop resistance. Herein, three butterfly-shaped aggregation-induced emission luminogens (AIEgens) with balanced nonradiative decay (for conducting PTT) radiative supplying fluorescence in the NIR-II optical window) are rationally designed imaging-assisted obliteration bacterial biofilms. After being encapsulated into cationic liposomes, AIEgens-fabricated nanoparticles can eradicate wide spectrum biofilms formed by Gram-positive (methicillin-resistant Staphylococcus aureus Enterococcus faecalis) Gram-negative (Escherichia coli Pseudomonas aeruginosa) upon an 808 nm laser irradiation. In vivo experiments firmly demonstrate that AIE liposomes excellent biocompatibility perform well both P. aeruginosa biofilm-induced keratitis mouse model MSRA skin infection model.

Language: Английский

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Advanced strategies of scaffolds design for bone regeneration

BMEMat, Journal Year: 2023, Volume and Issue: 1(4)

Published: Sept. 2, 2023

Abstract Bone defects are encountered substantially in clinical practice, and bionic scaffolds represent a promising solution for repairing bone defects. However, it is difficult to fabricate with structures reconstruct the microenvironment fulfill satisfying repair effects. In this review article, we first discuss various strategies design construction of promote defect repair, especially including structural scaffold integration bioactive substances together application external stimuli. We then roles artificial intelligence medical imaging aiding treatment. Finally, point out challenges future outlooks developing multifunctional scaffolds, aiming provide insights improving regeneration efficacy accelerating translation.

Language: Английский

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NIR‐II Light Accelerated Prodrug Reduction of Pt(IV)‐Incorporating Pseudo Semiconducting Polymers for Robust Degradation and Maximized Photothermal/Chemo‐Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(28)

Published: April 5, 2023

Abstract Selective activation of Pt(IV) prodrugs within tumors is particularly attractive because their low damage to normal tissues. However, current common via chemical/photoreduction into Pt(II) counterparts limited by undesirable spatial–temporal control over this reduction process and the ineffective tissue penetration depth light. Here, a pseudo‐conjugated‐polymer designed Stille polymerization, resulting in PSP‐Pt with prodrug oxaliplatin (Oxa(IV)) polymer main chain that can be activated NIR‐II co‐assemble commercially available lipid polymer, namely mPEG 2k ‐DSPE, NP . Under 1064 nm light irradiation, photoactivated accelerate release oxaliplatin, thereby killing cancer cells photothermal effect chemo‐immunotherapy inside mouse model CT26 colon cancer. This work reports application for accelerating tumor therapy.

Language: Английский

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An NIR‐II Excitable AIE Small Molecule with Multimodal Phototheranostic Features for Orthotopic Breast Cancer Treatment

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(14)

Published: Jan. 2, 2024

One-for-all phototheranostics, referring to a single component simultaneously exhibiting multiple optical imaging and therapeutic modalities, has attracted significant attention due its excellent performance in cancer treatment. Benefitting from the superiority balancing diverse competing energy dissipation pathways, aggregation-induced emission luminogens (AIEgens) are proven be ideal templates for constructing one-for-all multimodal phototheranostic agents. However, this knowledge, all-round AIEgens that can triggered by second near-infrared (NIR-II, 1000-1700 nm) light have not been reported. Given deep tissue penetration high maximum permissible exposure of NIR-II excitation light, herein, work reports first time an laser excitable AIE small molecule (named BETT-2) with features taking full use advantage molecule-facilitated versatility as well synchronously maximizing molecular donor-acceptor strength conformational distortion. As formulated into nanoparticles (NPs), BETT-2 NPs light-driven fluorescence-photoacoustic-photothermal trimodal imaging-guided photodynamic-photothermal synergistic therapy orthotopic mouse breast tumors is fully demonstrated systematic vitro vivo evaluations. This offers valuable insights developing activatable systems.

Language: Английский

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NIR‐II absorbing organic nanoagents for photoacoustic imaging and photothermal therapy

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Jan. 30, 2023

Abstract Near‐infrared (NIR) absorbing materials hold great potential in biomedical applications, such as fluorescence imaging (FLI), photoacoustic (PAI), photodynamic therapy (PDT), and photothermal (PTT). Generally, these can be classified into two main categories based on their wavelengths: the first NIR (NIR‐I) (~650–950 nm) second (NIR‐II) (~1000–1700 materials. Due to reduced absorption scattering of NIR‐II light tissue compared NIR‐I light, enable with improved contrast deepened penetration, which is favor practical applications. Various inorganic have been developed for phototheranostics recent years. However, non‐biodegradability toxicity hinder further clinical translation. Biocompatible organic biodegradability well tailored optical property are thus more desired. In this review, we summarize advances nanoagents (ONAs) small molecules (SMs) conjugated polymers (CPs) PAI PTT show our perspectives future challenges development

Language: Английский

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Recent advances in the design and applications of near-infrared II responsive small molecule phototherapeutic agents

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 505, P. 215677 - 215677

Published: Jan. 31, 2024

Language: Английский

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Tuning Shortwave‐Infrared J‐aggregates of Aromatic Ring‐Fused Aza‐BODIPYs by Peripheral Substituents for Combined Photothermal and Photodynamic Therapies at Ultralow Laser Power

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(11)

Published: Jan. 16, 2024

Abstract Achieving photothermal therapy (PTT) at ultralow laser power density is crucial for minimizing photo‐damage and allowing higher maximum permissible skin exposure. However, this requires agents to possess not just superior conversion efficiency (PCE), but also exceptional near‐infrared (NIR) absorptivity. J ‐aggregates, exhibit a significant redshift narrower absorption peak with extinction coefficient. Nevertheless, achieving predictable ‐aggregates through molecular design remains challenge. In study, we successfully induced desirable J‐ aggregation (λ abs max : 968 nm, ϵ: 2.96×10 5 M −1 cm , λ em 972 Φ FL 6.2 %) by tuning electrostatic interactions between π‐conjugated planes manipulating surface potential of aromatic ring‐fused aza‐BODIPY dyes. Notably, controlling the preparation method encapsulating dyes into F‐127 polymer, were able selectively generate H ‐/ respectively. Furthermore, exhibited two controllable morphologies: nanospheres nanowires. Importantly, shortwave‐infrared ‐aggregated nanoparticles impressive PCE 72.9 % effectively destroyed cancer cells mice‐tumors an 0.27 W −2 (915 nm). This phototherapeutic nano‐platform, which generates behavior, can controllably form / H‐ aggregates selectable aggregate morphology, valuable paradigm developing tumor‐treatment density.

Language: Английский

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Mechanism study of the photothermal function of lignin: the effect of electron-withdrawing groups

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(4), P. 2143 - 2156

Published: Jan. 1, 2024

The photothermal effect of lignin was significantly enhanced by introducing electron-withdrawing group attributing to the improved light absorption electron donor-acceptor structure and non-radiative decay through molecular motion.

Language: Английский

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An All‐Rounder for NIR‐II Phototheranostics: Well‐Tailored 1064 nm‐Excitable Molecule for Photothermal Combating of Orthotopic Breast Cancer

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(26)

Published: April 19, 2024

The second near-infrared (NIR-II, 1000-1700 nm) light-activated organic photothermal agent that synchronously enables satisfying NIR-II fluorescence imaging is highly warranted yet rather challenging on the basis of overwhelming nonradiative decay. Herein, such an agent, namely TPABT-TD, was tactfully designed and constructed via employing benzo[c]thiophene moiety as bulky electron donor/π-bridge tailoring peripheral molecular rotors. Benefitting from its high donor-acceptor strength finely modulated intramolecular motion, TPABT-TD simultaneously exhibits ultralong absorption in region, intense emission NIR-IIa (1300-1500 region nanoaggregates, conversion upon 1064 nm laser irradiation. Those intrinsic advantages endow nanoparticles with prominent fluorescence/photoacoustic/photothermal trimodal imaging-guided therapy against orthotopic 4T1 breast tumor negligible adverse effect.

Language: Английский

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