Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(5)
Published: Nov. 11, 2023
Abstract
Organic
transistors
possess
inherent
advantages
such
as
flexibility,
biocompatibility,
customizable
chemical
structures,
solution‐processability,
and
amplifying
capabilities,
making
them
highly
promising
for
portable
healthcare
sensor
applications.
Through
convenient
diverse
modifications
at
the
material
device
surfaces
or
interfaces,
organic
allow
a
wide
range
of
applications
spanning
from
biological
to
physical
sensing.
In
this
comprehensive
review,
surface
interface
engineering
aspect
associated
with
four
types
typical
sensors
is
focused.
The
operation
principles
sensing
mechanisms
are
systematically
analyzed
highlighted,
particularly
surface/interface
functionalization
strategies
that
contribute
enhancement
performance
An
outlook
perspective
on
critical
issues
challenges
in
field
using
provided
well.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Feb. 28, 2023
Abstract
Flexible
and
stretchable
biosensors
can
offer
seamless
conformable
biological–electronic
interfaces
for
continuously
acquiring
high‐fidelity
signals,
permitting
numerous
emerging
applications.
Organic
thin
film
transistors
(OTFTs)
are
ideal
transducers
flexible
biosensing
due
to
their
soft
nature,
inherent
amplification
function,
biocompatibility,
ease
of
functionalization,
low
cost,
device
diversity.
In
consideration
the
rapid
advances
in
flexible‐OTFT‐based
broad
applications,
herein,
a
timely
comprehensive
review
is
provided.
It
starts
with
detailed
introduction
features
various
OTFTs
including
organic
field‐effect
electrochemical
transistors,
functionalization
strategies
biosensing,
highlight
on
seminal
work
up‐to‐date
achievements.
Then,
applications
wearable,
implantable,
portable
electronics,
as
well
neuromorphic
biointerfaces
detailed.
Subsequently,
special
attention
paid
planar
fibrous
devices.
The
routes
impart
stretchability,
structural
engineering
material
engineering,
discussed,
implementations
e‐skin
smart
textiles
included.
Finally,
remaining
challenges
future
opportunities
this
field
summarized.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(4), P. 2118 - 2126
Published: Jan. 18, 2023
Herein,
we
demonstrated
a
strategy
to
regulate
the
conductive
metal–organic
framework
(MOF)
surface,
by
conjugated
molecule
wires
for
selective
and
sensitive
determination
of
dopamine
(DA)
in
live
brain.
The
MOFs
were
decorated
at
carbon
fiber
electrode
deposited
Au
nanoleaves
as
upper
electric
transducer
provide
rich
electrocatalytic
sites
electron
transfer
neurochemicals
leading
greatly
enhanced
sensitivity
detection
neurochemicals.
On
other
hand,
molecular
wire,
4-(thiophen-3-ylethynyl)-benzaldehyde
(RP1),
was
synthesized
assembled
an
underlying
bridge
electrochemical
processes
MOF-based
electrode,
specifically
decreasing
reaction
Gibbs
free
energy
DA
oxidation,
thus
selectively
promoting
heterogeneous
from
MOF
layer
surface.
Owing
activity
present
microsensor
exhibited
high
selectivity
real-time
tracking
good
linear
relationship
range
0.004–0.4
μM
with
limit
1
nM.
Eventually,
this
functionalized
successfully
applied
vivo
monitoring
mouse
brains
Parkinson's
disease
(PD)
model.
results
indicated
that
levels
obviously
decreased
both
acute
subacute
PD
models.
Moreover,
level
strongly
depended
on
amount
uric
acid
(UA),
physiological
antioxidant,
which
rose
UA
lower
than
200
mg
kg–1
but
downregulated
again
after
treatment
higher
UA.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(27)
Published: Jan. 23, 2024
The
improvement
of
living
standards
and
the
advancement
medical
technology
have
led
to
an
increased
focus
on
health
among
individuals.
Detections
biomarkers
are
feasible
approaches
obtaining
information
about
status,
disease
progression,
response
treatment
individual.
In
recent
years,
organic
electrochemical
transistors
(OECTs)
demonstrated
high
electrical
performances
effectiveness
in
detecting
various
types
biomarkers.
This
review
provides
overview
working
principles
OECTs
their
performance
multiple
biomarkers,
with
a
advances
representative
applications
wearable
implantable
biomarker
detections,
perspective
for
future
development
OECT-based
sensors.
ECS Sensors Plus,
Journal Year:
2024,
Volume and Issue:
3(2), P. 020601 - 020601
Published: April 1, 2024
Dopamine
is
an
essential
neurotransmitter
for
daily
cognitive
functions
controlling
many
neurophysiological
processes
including
memory,
cognition,
and
physical
control.
Development
of
analytical
methods
sensors
to
detect
dopamine
important
health
monitoring
neurological
research.
This
review
provides
overview
recent
advances
in
the
development
electrochemical
catalytic
biosensors
based
on
enzyme
enzyme-mimetic
materials
discusses
their
potential
applications
measurements
biological
fluids.
The
first
part
summarizes
critically
assesses
different
types
enzymes
mimetic
that
can
be
used
catalytically
convert
dopamine,
followed
by
a
discussion
biosensor’s
fabrication,
key
design
parameters,
detection
mechanism
various
electrode
platforms
ranging
from
single-use
screen-printed
electrodes
microneedles
implantable
microelectrodes.
second
examples
samples,
saliva,
urine,
serum,
cell
cultures,
brain
tissue.
We
conclude
with
summary
advantages
limitations
these
devices
clinical
field,
outlook
future
research
towards
implementation
broader
adoption
neurophysiology,
pharmacology,
field.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(45)
Published: May 31, 2024
Abstract
The
pursuit
of
high
on‐to‐off
ratio
(
I
On
/
Off
),
as
one
the
important
performances
for
organic
electrochemical
transistor
(OECT)
has
been
ongoing,
but
to
date,
limited
solutions
are
available.
interaction
between
light
and
matter
demonstrated
a
rich
source
advanced
electronic
applications.
However,
its
potential
in
modulation
not
fully
explored.
Herein,
challenge
is
addressed
through
unique
light‐material
interplay,
which
represented
by
photoelectrochemical
(OPECT)
gated
photosensitive
COF‐LZU1
on
mixed‐ligand
MOF
(COF‐on‐MOF)
upon
appropriate
exposure
illumination.
Notably,
interplay
COF‐on‐MOF
can
adjust
device
physics,
optimizing
maximum
enhancing
signal
transduction.
Toward
bio‐application,
via
exonuclease‐assisted
cyclic
cleavage
amplification
hybridization
chain
reaction,
such
validated
highly
sensitive
detection
capabilities
human
T‐cell
lymphotropic
virus
type
II
(HTLV‐II)
DNA
down
0.003
fM.
This
study
features
possibility
Ag/AgCl‐like
photogating
transistors
light‐matter
interplay.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
The
spontaneous
aggregation
of
amyloid-β
(Aβ)
leads
to
neuronal
cell
death
in
the
brain
and
causes
development
Alzheimer's
disease
(AD).
efficient
detection
state
Aβ
holds
significant
promise
for
early
diagnosis
subsequent
treatment
this
neurodegenerative
disorder.
Currently,
most
fluorescent
probes
used
fibrils
share
similar
recognition
moieties,
such
as
N,N-dimethylamino
group,
N,N-diethylamino
piperidyl
group.
incorporating
novel
groups
will,
principle,
bring
new
properties
imaging
aggregates.
Herein,
we
designed
synthesized
three
(1
CarbCN,
2
NTCN,
3
NCarbCN)
based
on
dicyanoisophorone.
probe
NCarbCN,
which
integrated
two
a
carbamate
unit
(a
group)
together
with
showed
sensitive
turn-on
fluorescence
response
toward
Aβ,
along
high
binding
affinity
(Kd
=
59
nM)
selectivity
fibrils.
Theoretical
calculations
revealed
that
NCarbCN
could
provide
an
additional
hydrogen
bonding
interaction
Aβ42
Furthermore,
efficiently
crossed
blood-brain
barrier
exhibited
higher
brains
AD
model
mice.
Co-staining
isolated
sections
monoclonal
antibody
further
demonstrated
specific
plaques
mice,
thus
demonstrating
its
great
potential
disorders.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
35(9)
Published: Dec. 23, 2022
Recording
brain
neural
signals
and
optogenetic
neuromodulations
open
frontiers
in
decoding
information
neurodegenerative
disease
therapeutics.
Conventional
implantable
probes
suffer
from
modulus
mismatch
with
biological
tissues
an
irreconcilable
tradeoff
between
transparency
electron
conductivity.
Herein,
a
strategy
is
proposed
to
address
these
tradeoffs,
which
generates
conductive
transparent
hydrogels
polypyrrole-decorated
microgels
as
cross-linkers.
The
optical
of
the
electrodes
can
be
attributed
special
structures
that
allow
light
waves
bypass
microgel
particles
minimize
their
interaction.
Demonstrated
by
probing
hippocampus
rat
brains,
biomimetic
electrode
shows
prolonged
capacity
for
simultaneous
neuromodulation
recording
signals.
More
importantly,
intriguing
brain-machine
interaction
realized,
involves
signal
input
brain,
generation,
controlling
limb
behaviors.
This
breakthrough
work
represents
significant
scientific
advancement
toward
developing
therapies.
Proceedings of the National Academy of Sciences,
Journal Year:
2022,
Volume and Issue:
119(34)
Published: Aug. 16, 2022
As
nitric
oxide
(NO)
plays
significant
roles
in
a
variety
of
physiological
processes,
the
capability
for
real-time
and
accurate
detection
NO
live
organisms
is
great
demand.
Traditional
assessments
rely
on
indirect
colorimetric
techniques
or
electrochemical
sensors
that
often
comprise
rigid
constituent
materials
can
hardly
satisfy
sensitivity
spatial
resolution
simultaneously.
Here,
we
report
flexible
highly
sensitive
biosensor
based
organic
transistors
(OECTs)
capable
continuous
wireless
biological
systems.
By
modifying
geometry
active
channel
gate
electrodes
OECTs,
devices
achieve
optimum
signal
amplification
NO.
The
sensor
exhibits
low
response
limit,
wide
linear
range,
high
sensitivity,
excellent
selectivity,
with
miniaturized
sensing
region
compared
conventional
sensor.
device
demonstrates
nanomolar
range
cultured
cells
hours
without
drift.
Real-time
measurement
accomplished
8
d
articular
cavity
New
Zealand
White
rabbits
anterior
cruciate
ligament
(ACL)
rupture
injuries.
observed
level
associated
onset
osteoarthritis
(OA)
at
later
stage.
proposed
platform
could
provide
critical
information
early
diagnosis
chronic
diseases
timely
medical
intervention
to
optimize
therapeutic
efficacy.
