Journal of Materials Science, Journal Year: 2025, Volume and Issue: unknown
Published: May 4, 2025
Language: Английский
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 440 - 440
Published: March 29, 2025
Background/Objectives: The utilization of amphiphilic Pt(IV) complexes as prodrugs offers a promising strategy to revolutionize Pt-based cancer therapy by enhancing drug delivery and activation. While PEGylation is widely used optimize properties, its impact on the biological behavior remains unclear. This study systematically investigates how varying molecular weights influences their cytotoxicity, cellular uptake, Methods: were synthesized with PEG chains different using HATU-catalyzed amide bond formation copper-free click chemistry. Their properties assessed through cell-based analyses, focusing activation reductants. Results: Small modifications retained potent cytotoxicity prodrugs, whereas large significantly reduced efficacy. decrease in potency was linked impaired uptake mitochondrial accumulation. Additionally, slowed reduction reductants, further limiting anticancer activities. Conclusions: These findings underscore critical role metallodrug design provide key insights into optimizing strategies for platinum–based therapies.
Language: Английский
Citations
0
Nature Reviews Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 4, 2025
Language: Английский
Citations
0
Polymers, Journal Year: 2025, Volume and Issue: 17(8), P. 1010 - 1010
Published: April 9, 2025
Hypoxic tumors pose considerable obstacles to cancer treatment, as diminished oxygen levels can impair drug effectiveness and heighten therapeutic resistance. Oral cancer, a prevalent malignancy, encounters specific challenges owing its intricate anatomical structure the technical difficulties in achieving complete resection, thereby often restricting treatment efficacy. The impact of hypoxia is particularly critical influencing both response prognosis oral cancers. This article summarizes examines potential polymer nanomedicines address these challenges. By engineering that specifically react hypoxic tumor microenvironment, pharmaceuticals markedly enhance targeting precision effectiveness. Polymer efficacy while reducing side effects by hypoxia-targeted accumulation. emphasizes overcome resistance frequently observed improving delivery bioavailability anticancer agents. Furthermore, this review elucidates design application for treating tumors, highlighting their transformative therapy. Finally, gives an outlook on stimuli-responsive polymeric cancer.
Language: Английский
Citations
0
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
Selective inhibition of TrxR1 over TrxR2 is a highly sought-after goal, because the two enzymes play distinct roles in cancer progression. However, achieving targeted challenging due to their high homology and identical active site sequence. Herein we report new subcellular photocatalysis approach for by controllably activating organogold(I) prodrugs within cytosol, exclusive location TrxR1. The NHC-Au(I)-alkynyl complexes are stable evenly distributed cell; they can meanwhile be efficiently transformed into NHC-Au(I)-L species (L = labile ligands) via radical mechanism photocatalysts released cytosol (from endosome/lysosome) upon light irradiation, leading selective without affecting TrxR2. This results strong cytotoxicity cells with much higher selectivity than auranofin, pan TrxR inhibitor that cannot discriminate TrxR1/2, along potent antitumor activities multiple zebrafish mouse models. prodrug activation may thus suggest novel precision targeting using remarkable spatial control photocatalysis.
Language: Английский
Citations
0
Journal of Materials Science, Journal Year: 2025, Volume and Issue: unknown
Published: May 4, 2025
Language: Английский
Citations
0