Electroreductive Cross‐Electrophile Coupling of Aziridines and Aryl Bromides DOI

Guoqing Yang,

Yanwei Wang, Youai Qiu

et al.

Chemistry - A European Journal, Journal Year: 2023, Volume and Issue: 29(36)

Published: April 18, 2023

Herein, a nickela-electrocatalyzed cross-electrophile coupling of readily available aryl aziridines and bromides under mild sustainable electrochemical conditions to access synthetic useful β-arylethylamines is developed. This protocol characterized by its exquisite chemo- regioselectivity, broad substrate scope good functional group compatibility. Mechanistic studies confirmed that the regioselectivity reactivity observed are result electro-induced ring-opening electroreductive generate benzyl radical intermediate as active species. Furthermore, this strategy also enables cross-coupling with CO2 β-amino acids conditions.

Language: Английский

Electro-reductive carboxylation of acyclic C(sp3)–C(sp3) bonds in aromatic hydrocarbons with CO2 DOI

Chuan‐Kun Ran,

Quan Qu,

Yang-Yi Tao

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(10), P. 3366 - 3372

Published: Aug. 16, 2024

Language: Английский

Citations

10
Organo-mediator enabled electrochemical transformations DOI
Wei-Mei Zeng, Yanwei Wang,

Chunhui Peng

et al.

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review highlights organo-mediators that enable electrochemical reactions via outer-sphere electron transfer (ET), offering advantages such as availability, tunability, and simplified post-processing compared to direct electrolysis.

Language: Английский

Citations

1
Recent advances in the electrochemically mediated chemical transformation of carbon dioxide DOI
Ziqi Yu, Min Shi

Chemical Communications, Journal Year: 2022, Volume and Issue: 58(98), P. 13539 - 13555

Published: Jan. 1, 2022

This Minireview highlights recent advancements within five years (since 2017) in electrocarboxylation with CO 2 under mild conditions.

Language: Английский

Citations

35
Metal-free electrochemical dihydroxylation of unactivated alkenes DOI Creative Commons
Min Liu, Tian Feng, Yanwei Wang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 13, 2023

Herein, a metal-free electrochemical dihydroxylation of unactivated alkenes is described. The transformation proceeds smoothly under mild conditions with broad range alkenes, providing valuable and versatile dihydroxylated products in moderate to good yields without the addition costly transition metals stoichiometric amounts chemical oxidants. Moreover, this method can be applied natural pharmaceutical derivatives, further demonstrating its synthetic utility. Mechanistic studies have revealed that iodohydrin epoxide intermediate are formed during reaction process.

Language: Английский

Citations

22
Electroreductive Cross‐Electrophile Coupling of Aziridines and Aryl Bromides DOI

Guoqing Yang,

Yanwei Wang, Youai Qiu

et al.

Chemistry - A European Journal, Journal Year: 2023, Volume and Issue: 29(36)

Published: April 18, 2023

Herein, a nickela-electrocatalyzed cross-electrophile coupling of readily available aryl aziridines and bromides under mild sustainable electrochemical conditions to access synthetic useful β-arylethylamines is developed. This protocol characterized by its exquisite chemo- regioselectivity, broad substrate scope good functional group compatibility. Mechanistic studies confirmed that the regioselectivity reactivity observed are result electro-induced ring-opening electroreductive generate benzyl radical intermediate as active species. Furthermore, this strategy also enables cross-coupling with CO2 β-amino acids conditions.

Language: Английский

Citations

18