Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 14, 2024
Abstract
Molecular
rotary
motors
undergo
directional
motions
upon
input
of
external
energy
and
represent
archetypical
molecular
machines.
Light
driven
variants
stand
out
as
particularly
easy
to
fuel
continuously
potentially
carrying
a
very
high
content
during
their
action.
So
far,
such
function
via
light
induced
bond
rotations
where
the
directionality
is
dictated
by
fixed
source
asymmetry
within
structure.
During
operation
cycle
there
no
further
structural
change
happening
except
for
rotation
itself.
In
this
work
we
disclose
hitherto
unknown
highly
effective
mechanism
motor
rotation,
which
makes
use
constitutional
alteration
This
in
turn
allows
be
controlled
actively
an
intramolecular
hydrogen
instead
sterics.
Associated
with
unusual
that
retains
from
incident
light,
great
importance
application
working
under
load.
With
these
findings
unique
possibilities
emerge
design
unprecedented
modes
action
power.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 21, 2024
Abstract
Molecular
photoswitches
produce
light‐controlled
changes
at
the
nanometer
scale
and
can
therefore
be
used
to
alter
states
behavior
of
materials
in
a
truly
bottom‐up
fashion.
Here
an
escalating
photonic
complexity
material
property
control
with
light
is
shown
using
recently
developed
aza‐diarylethene
combination
hemiindigo
(HI)
photoswitches.
First,
as
photoswitch
polystyrene
(PS)
reversibly
inscribe
relief‐type
3D
structures
into
PS.
Second,
further
photoinitiator
for
light‐induced
polymerization
methyl
acrylate
(MA),
demonstrating
first
time
chemical
reactivity
its
zwitterionic
switching
state.
Third,
HIs
are
implemented
polymerized
MA,
generating
photochromic
polymers.
At
fourth
level,
binary
mixture
allows
synergize
aza‐diarylethene‐induced
photopolymerization
localized
photochromism
simultaneously
entrapped
functional
HI.
With
such
multilevel
response,
utility
this
particular
applications
advanced
demonstrated.
ChemistrySelect,
Journal Year:
2023,
Volume and Issue:
8(41)
Published: Nov. 5, 2023
Abstract
Hemithioindigos
were
designed
as
topoisomerase
inhibitors,
synthesized,
and
evaluated
for
their
anticancer
properties
against
lung
(A549)
breast
(MDA‐MB‐468
MCF7)
cancer
cell
lines.
Among
all
the
synthetics,
three
compounds
exerted
potential
effects
on
A549
(lung)
MCF7
(breast)
lines
at
low
micromolar
concentrations.
The
results
revealed
that
two
of
these
blocked
cells
G1/S
phase,
while
third
compound
showed
moderate
G2/M
inhibition,
leading
to
necrotic
death.
Finally,
inhibition
assays
potent
Topo
I/II
inhibitory
actions
one
primary
mechanisms.
Molecular
docking
studies
further
corroborated
findings.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 14, 2024
Abstract
Molecular
rotary
motors
undergo
directional
motions
upon
input
of
external
energy
and
represent
archetypical
molecular
machines.
Light
driven
variants
stand
out
as
particularly
easy
to
fuel
continuously
potentially
carrying
a
very
high
content
during
their
action.
So
far,
such
function
via
light
induced
bond
rotations
where
the
directionality
is
dictated
by
fixed
source
asymmetry
within
structure.
During
operation
cycle
there
no
further
structural
change
happening
except
for
rotation
itself.
In
this
work
we
disclose
hitherto
unknown
highly
effective
mechanism
motor
rotation,
which
makes
use
constitutional
alteration
This
in
turn
allows
be
controlled
actively
an
intramolecular
hydrogen
instead
sterics.
Associated
with
unusual
that
retains
from
incident
light,
great
importance
application
working
under
load.
With
these
findings
unique
possibilities
emerge
design
unprecedented
modes
action
power.
