Molecules,
Journal Year:
2023,
Volume and Issue:
28(3), P. 1338 - 1338
Published: Jan. 31, 2023
Traditional
macrocyclic
molecules
encode
recognition
sites
in
their
structural
backbones,
which
limits
the
variation
of
and
thus,
would
restrict
adjustment
properties.
Here,
we
report
a
new
oligoamide-based
macrocycle
capable
varying
functional
groups
by
post-synthesis
modification
on
its
backbone.
Through
six
steps
common
reactions,
parent
(9)
can
be
produced
gram
scale
with
an
overall
yield
31%.
The
9
to
vary
are
demonstrated
producing
four
different
macrocycles
(10–13)
distinct
groups,
2-methoxyethoxyl
(10),
hydroxyl
(11),
carboxyl
(12)
amide
(13),
respectively.
1H
NMR
study
suggests
that
structure
these
is
consistent
our
design,
i.e.,
forming
hydrogen
bonding
network
at
both
rims
1H-1H
NOESY
indicates
located
inside
cavity
macrocycles.
At
last,
preliminary
molecular
shows
10
recognize
n-octyl-β-D-glucopyranoside
(14)
chloroform.
Chemical Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
feature
article
presents
cyclophane-based
host–guest
complexes
for
which
electronic
interactions
between
the
host
and
guest
molecules
can
modulate
excited-state
properties
in
an
advanced
way
involving
both
singlet
triplet
excited
states.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
62(1)
Published: Sept. 22, 2022
Abstract
The
tetracationic
cyclophane,
cyclobis(paraquat‐
p
‐phenylene),
also
known
as
the
little
blue
box,
constitutes
a
modular
receptor
that
has
facilitated
discovery
of
many
host–guest
complexes
and
mechanically
interlocked
molecules
during
past
35
years.
Its
versatility
in
binding
small
π‐donors
its
state,
well
forming
trisradical
tricationic
with
viologen
radical
cations
doubly
reduced
bisradical
dicationic
renders
it
valuable
for
construction
various
stimuli‐responsive
materials.
Since
first
reports
1988,
box
been
featured
over
500
publications
literature.
All
this
research
activity
would
not
have
possible
without
seminal
contributions
carried
out
by
Siegfried
Hünig,
who
only
pioneered
syntheses
viologen‐containing
cyclophanes,
but
revealed
their
rich
redox
chemistry
addition
to
ability
undergo
intramolecular
π‐dimerization.
This
Review
describes
how
his
pioneering
led
design
synthesis
redox‐active
host
evolved
into
key
component
molecular
shuttles,
switches,
machines.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(31)
Published: June 7, 2023
Macrocyclic
molecule-based
host-guest
systems,
which
provide
contributions
for
the
design
and
construction
of
functional
supramolecular
structures,
have
gained
increasing
attention
in
recent
years.
In
particular,
platinum(II)
metallacycle-based
systems
opportunities
chemical
scientists
to
prepare
novel
materials
with
various
functions
structures
due
well-defined
shapes
cavity
sizes
metallacycles.
However,
research
on
has
been
given
little
attention.
this
article,
we
demonstrate
complexation
between
a
metallacycle
polycyclic
aromatic
hydrocarbon
molecule,
naphthalene.
Taking
advantage
interactions
dynamic
property
reversible
Pt
coordination
bonds,
[2]rotaxane
is
efficiently
prepared
by
employing
template-directed
clipping
procedure.
The
further
applied
fabrication
an
efficient
light-harvesting
system
multi-step
energy
transfer
process.
This
work
comprises
important
supplement
macrocycle-based
demonstrates
strategy
production
mechanically
interlocked
molecules
practical
values.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(8)
Published: Jan. 2, 2024
Abstract
Inspired
by
the
drawstring
structure
in
daily
life,
here
we
report
development
of
a
drawstring‐mimetic
supramolecular
complex
at
molecular
scale.
This
consists
rigid
figure‐of‐eight
macrocyclic
host
molecule
and
flexible
linear
guest
which
could
interact
through
three‐point
non‐covalent
binding
to
form
highly
selective
efficient
host‐guest
assembly.
The
not
only
resembles
structure,
but
also
mimics
properties
with
regard
deformations
under
external
forces.
can
be
utilized
as
an
interlocked
crosslinker
for
poly(methyl
acrylate),
corresponding
polymer
samples
exhibit
comprehensive
enhancement
macroscopic
mechanical
performance
including
stiffness,
strength,
toughness.
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 26, 2025
Abstract
Differential
sensing,
inspired
by
the
olfactory
systems
in
mammals,
utilizes
cross‐reactivity
of
multiple
sensor
units
toward
analytes
to
generate
a
distinctive
fingerprint
for
each
analyte.
Widely
acknowledged
as
robust
analytical
technique,
differential
sensing
has
entered
flourishing
era
with
advancement
machine
learning.
Nevertheless,
developing
and
optimizing
signal
transduction
remain
significant
tasks
left
chemists.
Macrocyclic
receptors
serve
promising
materials
constructing
arrays
enhanced
cross‐reactivity,
facilitated
their
ease
synthesis
derivatization,
inherent
broad‐spectrum
encapsulation
capability,
compatibility
responsive
approaches.
Herein,
we
present
concise
overview
fundamental
processes
involved
array,
encompassing
array
construction,
transduction,
data
acquisition
analysis,
an
emphasis
on
unique
advantages
provided
macrocyclic
former
two
aspects.
Then,
fascinating
application
scenarios
where
shine
that
rely
various
ingenious
strategies.
Finally,
discuss
several
issues
potential
improvement
future
directions
receptor‐based
offering
forward‐looking
perspective.
Chemical Science,
Journal Year:
2023,
Volume and Issue:
14(13), P. 3523 - 3530
Published: Jan. 1, 2023
The
photosensitizers
(PSs)
for
photodynamic
therapy
(PDT)
mostly
possess
conjugated
skeletons
that
are
over-sized
and
poorly
water-soluble
to
be
encapsulated
by
conventional
macrocyclic
receptors.
Herein,
we
report
two
fluorescent
hydrophilic
cyclophanes,
AnBox·4Cl
ExAnBox·4Cl,
can
effectively
bind
hypocrellin
B
(HB),
a
pharmaceutically
active
natural
PS
PDT,
with
binding
constants
of
the
107
level
in
aqueous
solutions.
macrocycles
feature
extended
electron-deficient
cavities
facilely
synthesized
through
photo-induced
ring
expansions.
corresponding
supramolecular
PSs
(HB⊂AnBox4+
HB⊂ExAnBox4+)
exhibit
desirable
stability,
biocompatibility,
cellular
delivery,
as
well
excellent
PDT
efficiency
against
cancer
cells.
In
addition,
living
cell
imaging
results
indicate
HB⊂AnBox4+
HB⊂ExAnBox4+
have
different
delivery
effects
at
level.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(24), P. 6225 - 6239
Published: Jan. 1, 2023
This
review
focuses
on
the
eight-shaped
double
ring
structure
of
tetraphenylethylene,
summarizes
research
progress
structures,
ionic
molecular
structures
and
metal
looks
forward
to
its
future
development
direction.
Smart Molecules,
Journal Year:
2023,
Volume and Issue:
1(3)
Published: Oct. 23, 2023
Abstract
Natural
molecular
machines
have
inspired
the
development
of
artificial
machines,
which
potential
to
revolutionize
several
areas
technology.
Artificial
commonly
employ
switches,
motors,
and
shuttles
as
fundamental
building
blocks.
The
observation
constructed
by
these
blocks
can
be
highly
challenging
due
their
small
sizes
intricate
behaviors.
use
modern
instrumentation
advanced
observational
techniques
plays
a
crucial
role
in
characterization
machines.
Furthermore,
well‐designed
structure
is
also
critical
factor
making
more
observable.
This
review
summarizes
common
methods
from
diverse
perspectives
used
observe
emphasizes
significance
comprehending
behaviors
design
superior
Beilstein Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
20, P. 504 - 539
Published: March 1, 2024
Switchable
molecular
tweezers
are
a
unique
class
of
switches
that,
like
their
macroscopic
analogs,
exhibit
mechanical
motion
between
an
open
and
closed
conformation
in
response
to
stimuli.
Such
systems
constitute
essential
component
artificial
machines.
This
review
will
present
selected
examples
switchable
potential
applications.
The
first
part
be
devoted
chemically
responsive
tweezers,
including
stimuli
such
as
pH,
metal
coordination,
anion
binding.
Then,
redox-active
photochemical
presented.
