Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(23), P. 6819 - 6849
Published: Jan. 1, 2024
This
review
highlights
recent
advances
in
the
atroposelective
preparation
of
axially
chiral
azole
derivatives,
emphasizing
mechanistic
insights
and
synthetic
applications
development
this
class
five-membered
heterocyclic
frameworks.
Deleted Journal,
Journal Year:
2023,
Volume and Issue:
2, P. e9120051 - e9120051
Published: Jan. 5, 2023
Borophene,
as
a
rising-star
monoelemental
two-dimensional
(2D)
material,
has
motivated
great
interest
because
of
its
novel
properties,
such
anisotropic
plasmonics,
high
carrier
mobility,
mechanical
compliance,
optical
transparency,
ultrahigh
thermal
conductance,
and
superconductivity.
These
properties
make
it
an
ideal
candidate
for
use
in
the
field
energy,
sensors,
information
storage.
Stimulated
by
realization
pioneering
experimental
works
2015
follow-up
synthesis
experiments,
series
high-performance
borophene-based
devices
fields,
including
supercapacitors,
batteries,
hydroelectric
generators,
humidity
gas
pressure
memories,
have
been
experimentally
reported
recent
years,
which
are
beneficial
to
transition
materials
from
practical
application.
Therefore,
addition
paying
attention
preparation
borophene,
significant
efforts
needed
promote
advancement
related
applications
borophene.
In
this
review,
after
providing
brief
overview
borophene
evolution
synthesis,
we
mainly
summarize
energy
storage,
conversion,
harvesting,
Finally,
based
on
current
research
status,
some
rational
suggestions
discussions
issues
challenges
future
direction
proposed.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
63(3)
Published: Nov. 2, 2023
With
the
rapid
development
of
asymmetric
catalysis,
demand
for
enantioselective
synthesis
complex
and
diverse
molecules
with
different
chiral
elements
is
increasing.
Owing
to
unique
features
atropisomerism,
catalytic
atropisomers
has
attracted
a
considerable
interest
from
chemical
science
community.
In
particular,
introducing
additional
elements,
such
as
carbon
centered
chirality,
heteroatomic
planar
helical
into
provides
an
opportunity
incorporate
new
properties
axially
compounds,
thus
expanding
potential
applications
atropisomers.
Thus,
it
important
perform
transformations
synthesize
bearing
multiple
elements.
spite
challenges
in
transformations,
recent
years,
chemists
have
devised
powerful
strategies
under
organocatalysis
or
metal
synthesizing
wide
range
enantioenriched
Therefore,
become
emerging
field.
This
review
summarizes
progress
this
field
indicates
challenges,
thereby
promoting
horizon.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(9), P. 6283 - 6293
Published: Feb. 21, 2024
We
herein
introduce
biarylhemiboronic
esters
as
a
new
type
of
bridged
biaryl
reagent
for
asymmetric
synthesis
axially
chiral
structures,
and
the
palladium-catalyzed
Suzuki-Miyaura
cross-coupling
is
developed.
This
dynamic
kinetic
atroposelective
coupling
reaction
exhibits
high
enantioselectivity,
good
functional
group
tolerance,
broad
substrate
scope.
The
synthetic
application
current
method
was
demonstrated
by
transformations
product
programmed
polyarene.
Preliminary
mechanistic
studies
suggested
that
proceeded
via
an
enantio-determining
transmetalation
step.
ACS Catalysis,
Journal Year:
2023,
Volume and Issue:
13(14), P. 9713 - 9723
Published: July 11, 2023
The
3d
metallaelectro-catalyzed
C-H
activation
has
been
identified
as
an
increasingly
viable
strategy
to
access
valuable
organic
molecules
in
a
resource-economic
fashion
under
exceedingly
mild
reaction
conditions.
However,
the
development
of
enantioselective
is
very
challenging
and
its
infancy.
Here,
we
disclose
merger
cobaltaelectro-catalyzed
with
asymmetric
catalysis
for
highly
annulation
allenes.
A
broad
range
C-N
axially
chiral
P-stereogenic
compounds
were
thereby
obtained
good
yields
up
98%
high
enantioselectivities
>99%
ee.
practicality
this
approach
was
demonstrated
by
diversification
complex
bioactive
drug
well
decagram
scale
electrocatalysis
continuous
flow.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: July 24, 2023
Chiral
monodentate
biaryl
phosphines
(MOPs)
have
attracted
intense
attention
as
chiral
ligands
over
the
past
decades.
However,
creation
of
structurally
diverse
MOPs
with
both
P-
and
axial
chirality
is
still
in
high
demand
but
challenging.
Here,
we
show
a
distinct
strategy
for
diversity-oriented
synthesis
containing
enabled
by
enantioselective
C-P
bond
cleavage.
The
key
PdII
intermediates,
generated
through
stereoselective
oxidative
addition
bond,
could
be
trapped
alkynes,
R3Si-Bpin,
diboron
esters
or
reduced
H2O/B2pin2,
leading
to
enantioenriched
excellent
diastereo-
enantioselectivities.
Based
on
outstanding
properties
parent
scaffolds,
axially
serve
catalysts
asymmetric
[3
+
2]
annulation
MBH
carbonate
affording
functionalized
bicyclic
imide.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(22), P. 11165 - 11206
Published: Jan. 1, 2024
This
review
explores
the
fascinating
world
of
molecules
featuring
multiple
stereogenic
elements,
unraveling
different
strategies
designed
over
years
for
their
enantioselective
synthesis.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(8)
Published: Jan. 6, 2024
Atropisomeric
phosphines
hold
considerable
significance
in
asymmetric
catalysis,
yet
their
synthesis
presents
a
formidable
challenge
owing
to
intricate
multistep
procedures.
In
this
context,
groundbreaking
methodology
has
been
presented
for
preparation.
This
innovative
approach
entails
an
atroposelective
rhodium-catalyzed
C-H
activation
employing
aryl
and
heteroaryl
halides,
chelated
by
P(III)
center.
The
essence
of
strategy
lies
its
ability
directly
construct
chiral
phosphine
ligands
single
step,
thereby
exhibiting
exceptional
efficiency
terms
atom
redox
economy.
Illustrative
examples
serve
demonstrate
the
immense
potential
situ-formed
catalysis.
Mechanistic
experiments
have
further
provided
invaluable
insights
into
transformation.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 23, 2024
Abstract
Catalytic
enantioselective
preparation
of
alkene
atropisomers
with
multiple
stereogenic
elements
and
discovery
their
applications
have
become
significant
but
challenging
issues
in
the
scientific
community
due
to
unique
structures
this
class
atropisomers.
We
herein
report
first
catalytic
atroposelective
cyclopentenyl[
b
]indoles,
a
new
kind
atropisomers,
point
axial
chirality
via
an
unusual
rearrangement
reaction
3‐indolylmethanols
under
asymmetric
organocatalysis.
Notably,
novel
type
promising
developing
chiral
ligands
or
organocatalysts,
discovering
antitumor
drug
candidates
fluorescence
imaging
materials.
Moreover,
theoretical
calculations
elucidated
possible
mechanism
non‐covalent
interactions
control
enantioselectivity.
This
approach
offers
synthetic
strategy
for
elements,
represents
3‐indolylmethanols,
which
will
advance
chemistry
indole
chemistry.
ACS Catalysis,
Journal Year:
2023,
Volume and Issue:
13(24), P. 16300 - 16306
Published: Dec. 6, 2023
Thiourea-assisted
chiral
bicyclic
imidazole
organocatalysts
were
designed,
synthesized,
and
successfully
applied
in
the
asymmetric
acylative
desymmetrization
of
P-prochiral
bisphenols.
Under
mild
conditions,
P-stereogenic
products
obtained
high
yields
(up
to
99%
yield)
with
enantioselectivities
ee).
Most
importantly,
reaction
could
also
achieve
satisfactory
results
under
1
mol
%
catalyst
loadings.
Mechanistic
studies
showed
that
synergistic
effect
including
covalent
activation
acyl
group
by
nucleophilic
noncovalent
H-bonding
π-interaction
between
substrate
was
crucial
for
efficient
construction
P-stereocenters.