RSC Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
14(12), P. 2438 - 2458
Published: Jan. 1, 2023
One
of
the
world's
serious
health
challenges
is
cancer.
Anti-cancer
agents
delivered
to
normal
cells
and
tissues
pose
several
problems
challenges.
In
this
connection,
photodynamic
therapy
(PDT)
a
minimally
invasive
therapeutic
technique
used
for
selectively
destroying
malignant
while
sparing
tissues.
Development
in
photosensitisers
(PSs)
light
sources
have
be
made
PDT
as
first
option
treatment
patients.
pursuit
developing
new
attractive
molecules
their
formulations
PDT,
researchers
are
working
on
such
type
PSs
that
perform
better
than
those
being
currently
used.
For
widespread
clinical
utilization
effective
particular
importance.
Host-guest
interactions
based
nanographene
assemblies
functionalized
hexa-cata-hexabenzocoronenes,
hexa-peri-hexabenzocoronenes
coronene
attracted
increasing
attention
owing
less
complicated
synthetic
steps
purification
processes
(gel
permeation
chromatography)
during
fabrication.
Noncovalent
provide
easy
facile
approaches
building
supramolecular
enable
them
sensitive
controllable
photoactivities,
which
important
maximizing
effects
minimizing
side
effects.
Various
versatile
cyclodextrins,
cucurbiturils,
calixarenes,
porphyrins
pillararenes
been
designed
order
make
an
curing
cancer
tumours.
The
display
efficient
electron
transfer
fluorescence
use
bioimaging
PDT.
multifunctionalization
designing
biomedically
active
PSs,
helpful
It
anticipated
development
these
will
more
fascinating
advances
dramatically
expand
potential
possibilities
treatments.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(23), P. 3455 - 3458
Published: Jan. 1, 2023
An
L-arginine-functionalized
pillar[5]arene-based
supramolecular
photosensitizer
LAP5⊃NBSPD
was
constructed
by
host-guest
interactions,
which
could
self-assemble
into
nano-micelles
to
achieve
effective
delivery
and
selective
release
of
LAP5
NBS
in
cancer
cells.
In
vitro
studies
revealed
that
NPs
exhibited
excellent
cell
membrane
disruption
ROS
generation
properties,
provides
a
novel
route
for
synergistically
enhanced
therapeutic
effectiveness.
Interdisciplinary materials,
Journal Year:
2023,
Volume and Issue:
2(5), P. 689 - 713
Published: Sept. 1, 2023
Abstract
Chirality
is
an
omnipresent
structural
feature
found
in
nature.
The
transfer
and
amplification
of
chirality
are
widely
recognized
phenomena.
In
appropriate
solvents,
chiral
molecules
can
self‐assemble
into
diverse
supramolecular
nanomaterials
with
unique
properties.
the
past
two
decades,
there
has
been
a
growing
number
reported
nanomaterials.
Significant
advancements
have
made
within
these
materials,
as
well
their
regulation
applications.
Therefore,
it
essential
to
summarize
progress
this
field.
Here
we
present
comprehensive
overview
latest
nanomaterials,
ranging
from
This
review
aims
deepen
our
understanding
fundamental
origins
inherent
while
also
providing
reference
for
expanding
potential
Molecular Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
20(4), P. 2128 - 2137
Published: Feb. 27, 2023
To
overcome
the
hypoxia
barrier
in
tumor
therapy,
a
hypoxia-activated
prodrug
of
docetaxel
(DTX-PNB)
was
synthesized
and
self-assembled
with
indocyanine
green
(ICG),
forming
combination
nanomedicine
ISDNN.
With
guidance
molecular
dynamic
simulation,
ISDNN
construction
could
be
accurately
controlled,
achieving
uniform
size
distribution
high
drug
loading
up
to
90%.
Within
hypoxic
environment,
exerted
ICG-mediated
photodynamic
therapy
aggravated
boost
DTX-PNB
activation
for
chemotherapy,
enabling
enhanced
antitumor
efficacy.
RSC Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
14(12), P. 2438 - 2458
Published: Jan. 1, 2023
One
of
the
world's
serious
health
challenges
is
cancer.
Anti-cancer
agents
delivered
to
normal
cells
and
tissues
pose
several
problems
challenges.
In
this
connection,
photodynamic
therapy
(PDT)
a
minimally
invasive
therapeutic
technique
used
for
selectively
destroying
malignant
while
sparing
tissues.
Development
in
photosensitisers
(PSs)
light
sources
have
be
made
PDT
as
first
option
treatment
patients.
pursuit
developing
new
attractive
molecules
their
formulations
PDT,
researchers
are
working
on
such
type
PSs
that
perform
better
than
those
being
currently
used.
For
widespread
clinical
utilization
effective
particular
importance.
Host-guest
interactions
based
nanographene
assemblies
functionalized
hexa-cata-hexabenzocoronenes,
hexa-peri-hexabenzocoronenes
coronene
attracted
increasing
attention
owing
less
complicated
synthetic
steps
purification
processes
(gel
permeation
chromatography)
during
fabrication.
Noncovalent
provide
easy
facile
approaches
building
supramolecular
enable
them
sensitive
controllable
photoactivities,
which
important
maximizing
effects
minimizing
side
effects.
Various
versatile
cyclodextrins,
cucurbiturils,
calixarenes,
porphyrins
pillararenes
been
designed
order
make
an
curing
cancer
tumours.
The
display
efficient
electron
transfer
fluorescence
use
bioimaging
PDT.
multifunctionalization
designing
biomedically
active
PSs,
helpful
It
anticipated
development
these
will
more
fascinating
advances
dramatically
expand
potential
possibilities
treatments.
