1.6 Synthesis of Difluoromethylated Compounds DOI
Simin Wu, Hayeon Song, Mingyou Hu

et al.

Published: Jan. 1, 2024

Abstract The difluoromethyl group (CF2H) can function as a lipophilic hydrogen-bond donor, and is regarded bioisostere of functional groups such hydroxy (-OH), thiol (-SH), amino (-NH2). unique physicochemical properties this make difluoromethylation hot topic in the field synthetic organic chemistry, recent decades, various methods have been developed for constructing C(sp3)—CF2H, C(sp2)—CF2H, C(sp) —CF2H, X—CF2H (X = N, O, S, Se, B, P, etc.) bonds. This review summarizes currently available reagents performing reactions, well other approaches installing unit.

Language: Английский

1.6 Synthesis of Difluoromethylated Compounds DOI
Simin Wu, Hayeon Song, Mingyou Hu

et al.

Published: Jan. 1, 2024

Abstract The difluoromethyl group (CF2H) can function as a lipophilic hydrogen-bond donor, and is regarded bioisostere of functional groups such hydroxy (-OH), thiol (-SH), amino (-NH2). unique physicochemical properties this make difluoromethylation hot topic in the field synthetic organic chemistry, recent decades, various methods have been developed for constructing C(sp3)—CF2H, C(sp2)—CF2H, C(sp) —CF2H, X—CF2H (X = N, O, S, Se, B, P, etc.) bonds. This review summarizes currently available reagents performing reactions, well other approaches installing unit.

Language: Английский

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