The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 9103 - 9109
Published: June 6, 2024
A
brief,
practical
catalytic
process
for
the
production
of
optically
active
γ-functionalized
alcohols
from
relevant
alkenes
has
been
developed
by
using
a
robust
Mn(III)/air/(Me2SiH)2O
system
combined
with
lipase-catalyzed
kinetic
resolution.
This
approach
demonstrates
exceptional
tolerance
toward
proximal
functional
groups
present
on
alkenes,
enabling
achievement
high
yields
and
exclusive
enantioselectivity.
Under
this
sequential
system,
chiral
alkene
precursors
can
also
be
converted
into
related
acetates
as
separable
single
enantiomers.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(5), P. 2959 - 2966
Published: Jan. 25, 2024
The
mechanism
of
cyclopropanations
with
diazirines
as
air-stable
and
user-friendly
alternatives
to
commonly
employed
diazo
compounds
within
iron
heme
enzyme-catalyzed
carbene
transfer
reactions
has
been
studied
by
means
density
functional
theory
(DFT)
calculations
model
systems,
quantum
mechanics/molecular
mechanics
(QM/MM)
calculations,
molecular
dynamics
(MD)
simulations
the
cyclopropanation
transition
state
in
enzyme
active
site.
reaction
is
initiated
a
direct
diazirine-diazo
isomerization
occurring
site
enzyme.
In
contrast,
an
proceeding
via
formation
free
intermediate
lieu
direct,
one-step
process
was
observed
for
systems.
Subsequent
benzyl
acrylate
takes
place
through
stepwise
C–C
bond
diradical
intermediate,
delivering
cyclopropane
product.
origin
diastereo-
enantioselectivity
investigated
MD
simulations,
which
indicate
preferred
cis-cyclopropane
steric
control.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(15), P. 7875 - 7938
Published: Jan. 1, 2024
This
review
explores
linear
cascade
reactions
by
combining
chemo-,
photo-
and
biocatalysts
for
organic
synthesis
strategies
to
overcome
incompatibility
issues.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(28)
Published: April 17, 2024
While
simultaneously
proceeding
reactions
are
among
the
most
fascinating
features
of
biosynthesis,
this
concept
tandem
processes
also
offers
high
potential
in
chemical
industry
terms
less
waste
production
and
improved
process
efficiency
sustainability.
Although
examples
one-pot
chemoenzymatic
syntheses
exist,
combination
completely
different
reaction
types
is
rare.
Herein,
we
demonstrate
that
extreme
"antipodes"
"worlds
catalysis",
such
as
syngas-based
high-pressure
hydroformylation
biocatalyzed
reduction,
can
be
combined
within
a
tandem-type
water.
No
significant
deactivation
was
found
for
either
biocatalyst
or
chemocatalyst.
A
proof-of-concept
starting
from
1-octene
established
with
>99
%
conversion
80
isolated
yield
desired
alcohol
isomers.
All
necessary
components
biocatalysis
were
added
to
reactor
beginning.
This
has
been
extended
enantioselective
synthesis
chiral
products
by
conducting
styrene
an
enzymatic
dynamic
kinetic
resolution
mode,
leading
excellent
enantiomeric
ratio
91
:
9
(S)-2-phenylpropanol.
The
overall
runs
water
under
mild
energy-saving
conditions,
without
any
need
intermediate
isolation.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 6, 2024
Abstract
The
development
of
sustainable
chemistry
underlying
the
quest
to
minimize
and/or
valorize
waste
in
carbon‐neutral
manufacture
chemicals
is
followed
over
last
four
five
decades.
Both
chemo‐
and
biocatalysis
have
played
an
indispensable
role
this
odyssey.
particular
developments
protein
engineering,
metagenomics
bioinformatics
preceding
three
decades
a
crucial
supporting
facilitating
widespread
application
both
whole
cell
cell‐free
biocatalysis.
pressing
need,
driven
by
climate
change
mitigation,
for
drastic
reduction
greenhouse
gas
(GHG)
emissions,
has
precipitated
energy
transition
based
on
decarbonization
defossilization
organic
production.
latter
involves
biomass
CO
2
as
feedstock
green
electricity
generated
using
solar,
wind,
hydroelectric
or
nuclear
energy.
use
polysaccharides
feedstocks
will
underpin
renaissance
carbohydrate
with
pentoses
hexoses
base
bio‐based
solvents
polymers
environmentally
friendly
downstream
products.
availability
inexpensive
solar
led
increasing
attention
electro(bio)catalysis
photo(bio)catalysis
which
turn
leading
myriad
innovations
these
fields.
ACS Catalysis,
Journal Year:
2025,
Volume and Issue:
unknown, P. 2484 - 2491
Published: Jan. 27, 2025
Au(I)-catalyzed
hydration
of
aliphatic
terminal
alkynes
is
followed
by
transaminase-catalyzed
reductive
amination,
leading
to
enantioenriched
chiral
amines.
The
approach
features
a
one-pot
reaction
with
no
particular
need
for
compartmentalization
strategy.
Final
functionalization
performed
in
situ
leads
variety
amines,
pyrroles,
and
1-pyrrolines
obtained
high
enantioselectivities.
method
demonstrates
applicability
the
synthesis
bioactive
drugs
such
as
clobenzorex
(43%
yield,
3
steps,
96%
ee)
precursor
lisdexamfetamine
(34%
dr
98:2).
Chemical Science,
Journal Year:
2025,
Volume and Issue:
16(10), P. 4480 - 4489
Published: Jan. 1, 2025
Combining
chemical
and
whole-cell
catalysts
enables
sustainable
chemoenzymatic
cascade
reactions.
However,
their
traditional
combination
faces
challenges
in
catalyst
recycling
maintaining
cell
viability.
Here,
we
introduce
a
supramolecular
host-guest
strategy
that
efficiently
attaches
photocatalysts
to
bacterial
cells,
facilitating
recyclable
photobiocatalysis.
This
method
involves
attaching
cationic
polyethylenimine
(PEI)
polymer,
functionalized
with
β-cyclodextrin
(β-CD),
E.
coli
cells.
The
polymer
attachment
is
biocompatible
protective,
safeguarding
the
cells
from
harsh
conditions
such
as
UV
radiation
organic
solvents,
without
causing
death.
Additionally,
presence
of
β-CD
imparts
plug-and-play
capability
enabling
straightforward
integration
guest
-
specifically
anthraquinone
onto
surface
through
interactions.
effective
cellular
promotes
efficient
photobiocatalytic
cascades
supports
photocatalyst's
reuse.
system
thus
represents
promising
platform
for
advancing
photobiocatalysis
synthesis.
Communications Chemistry,
Journal Year:
2025,
Volume and Issue:
8(1)
Published: March 13, 2025
Communications
Chemistry
is
pleased
to
introduce
a
Collection
of
research
works
focused
on
recent
developments
within
the
interdisciplinary
field
chemoenzymatic
synthesis.
Here,
Guest
Editors
highlight
key
themes
and
look
towards
future
this
field.
