The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 9103 - 9109
Published: June 6, 2024
A
brief,
practical
catalytic
process
for
the
production
of
optically
active
γ-functionalized
alcohols
from
relevant
alkenes
has
been
developed
by
using
a
robust
Mn(III)/air/(Me2SiH)2O
system
combined
with
lipase-catalyzed
kinetic
resolution.
This
approach
demonstrates
exceptional
tolerance
toward
proximal
functional
groups
present
on
alkenes,
enabling
achievement
high
yields
and
exclusive
enantioselectivity.
Under
this
sequential
system,
chiral
alkene
precursors
can
also
be
converted
into
related
acetates
as
separable
single
enantiomers.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(15), P. 6041 - 6050
Published: Jan. 1, 2023
An
amine
transaminase
and
a
lipase
have
been
immobilised
in
separated
reactors
containing
EziG
polymer-coated
controlled
porosity
glass
carrier
materials
to
transform
1-phenoxypropan-2-one
into
the
corresponding
(
R
)-acetamide
organic
solvent.
Catalysts,
Journal Year:
2023,
Volume and Issue:
13(8), P. 1213 - 1213
Published: Aug. 15, 2023
In
recent
years,
Pd-containing
catalytic
systems
for
tandem
processes
have
gained
special
attention
due
to
their
enhanced
properties
and
possibility
of
performing
several
reactions
without
the
necessity
separating
intermediates.
this
review,
progress
in
Pd-catalyzed
is
considered.
Three
types
are
described:
homogeneous
catalysts
(including
immobilized
Pd
complexes);
heterogeneous
supported
on
oxides,
MOFs,
COFs,
etc.,
with
particular
supports
containing
acid/base
sites;
metal-enzyme
chemoenzymatic
applied
fine
organic
synthesis
biotechnology.
For
reactions,
different
were
considered,
i.e.,
cross-coupling,
cyclization,
carbonylation,
isomerization,
alkylation,
arylation,
etc.
Hydration
reactions
consist
of
the
introduction
a
molecule
water
into
chemical
compound.
This
process
is
particularly
useful
method
to
allow,
for
instance,
conversion
alkynes
carbonyls,
which
are
strategic
intermediates
in
synthesis
plethora
compounds.
Herein
we
demonstrate
that
L-cysteine
can
catalyse
hydration
activated
very
effective
and
fully
regioselective
manner
access
β-ketosulfones,
amides
esters
aqueous
conditions.
The
mild
reaction
conditions
facilitated
integration
with
enzyme
catalysis
chiral
β-hydroxy
sulfones
from
corresponding
one-pot
cascade
good
yields
excellent
enantiomeric
excess.
These
findings
pave
way
towards
establishing
general
metal-free,
cost-effective,
more
sustainable
alkyne
processes
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 8513 - 8520
Published: June 5, 2024
This
contribution
describes
the
development
of
chemoenzymatic
one-pot
processes,
which
combine
an
oxidative
rearrangement
and
a
biotransformation
catalyzed
by
imine
reductase
(IRED),
for
synthesis
highly
enantiomerically
enriched
secondary
amines,
such
as
aryl-substituted
pyrrolidine
benzazepine.
The
benefits
this
approach
include
high
overall
conversions
(up
to
>99%),
enantiomeric
excesses
>99%
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 9103 - 9109
Published: June 6, 2024
A
brief,
practical
catalytic
process
for
the
production
of
optically
active
γ-functionalized
alcohols
from
relevant
alkenes
has
been
developed
by
using
a
robust
Mn(III)/air/(Me2SiH)2O
system
combined
with
lipase-catalyzed
kinetic
resolution.
This
approach
demonstrates
exceptional
tolerance
toward
proximal
functional
groups
present
on
alkenes,
enabling
achievement
high
yields
and
exclusive
enantioselectivity.
Under
this
sequential
system,
chiral
alkene
precursors
can
also
be
converted
into
related
acetates
as
separable
single
enantiomers.
